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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12171 scientific papers returned from the database with the search filters currently being used below.

Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen

Authors:
Montasser ME, Van Hout CV, Miloscio L, Howard AD, Rosenberg A, Callaway M, Shen B, Li N, Locke AE, Verweij N, De T, Ferreira MA, Lotta LA, Baras A, Daly TJ, Hartford SA, Lin W, Mao Y, Ye B, White D, Gong G, Perry JA, Ryan KA, Fang Q, Tzoneva G, Pefanis E, Hunt C, Tang Y, Lee L; Regeneron Genetics Center Collaboration‡; Sztalryd-Woodle C, Mitchell BD, Healy M, Streeten EA, Taylor SI, O'Connell JR, Economides AN, Della Gatta G, Shuldiner AR
Citation:
Science. 2021 Dec 3;374(6572):1221-1227. doi: 10.1126/science.abe0348. Epub 2021 Dec 2. PMID: 34855475
Epub:
Not Epub
Abstract:
Increased blood levels of low-density lipoprotein cholesterol (LDL-C) and fibrinogen are independent risk factors for...
Link:
https://www.science.org/doi/10.1126/science.abe0348
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Montasser ME, Van Hout CV, Miloscio L, Howard AD, Rosenberg A, Callaway M, Shen B, Li N, Locke AE, Verweij N, De T, Ferreira MA, Lotta LA, Baras A, Daly TJ, Hartford SA, Lin W, Mao Y, Ye B, White D, Gong G, Perry JA, Ryan KA, Fang Q, Tzoneva G, Pefanis E, Hunt C, Tang Y, Lee L; Regeneron Genetics Center Collaboration‡; Sztalryd-Woodle C, Mitchell BD, Healy M, Streeten EA, Taylor SI, O'Connell JR, Economides AN, Della Gatta G, Shuldiner AR. Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen. Science. 2021 Dec 3;374(6572):1221-1227. doi: 10.1126/science.abe0348. Epub 2021 Dec 2. PMID: 34855475.

A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus

Authors:
Li J, Perfetto M, Materna C, Li R, Thi Tran H, Vleminckx K, Duncan MK, Wei S
Citation:
Sci Rep. 2019 Aug 1;9(1):11191. doi: 10.1038/s41598-019-47665-9. PMID: 31371771; PMCID: PMC6672020
Epub:
Not Epub
Abstract:
During vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6672020/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Li J, Perfetto M, Materna C, Li R, Thi Tran H, Vleminckx K, Duncan MK, Wei S. A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus. Sci Rep. 2019 Aug 1;9(1):11191. doi: 10.1038/s41598-019-47665-9. PMID: 31371771; PMCID: PMC6672020.

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.

Authors:
Morishima T, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefańczyk S, Lindner C, Oswald B, Bernhard R, Hähnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Müller P, Bajoghli B, Skokowa J
Citation:
Blood. 2019 Jul 31. pii: blood 2019000095. doi: 10.1182/blood.2019000095. [Epub ahead of print]
Epub:
Yes
Abstract:
LMO2 (hematopoietic transcription factor LIM domain only 2), a member of the TAL1 transcriptional complex, plays an essential...
Link:
http://www.bloodjournal.org/content/early/2019/07/31/blood.2019000095
Organism or Cell Type:
zebrafish
Citation Extract:
Morishima T, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefańczyk S, Lindner C, Oswald B, Bernhard R, Hähnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Müller P, Bajoghli B, Skokowa J. LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. . Blood. 2019 Jul 31. pii: blood 2019000095. doi: 10.1182/blood.2019000095. [Epub ahead of print].

Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons

Authors:
Seifinejad A, Li S, Mikhail C, Vassalli A, Pradervand S, Arribat Y, Pezeshgi Modarres H, Allen B, John RM, Amati F, Tafti M
Citation:
Proc Natl Acad Sci U S A. 2019 Aug 2. pii: 201902148. doi: 10.1073/pnas.1902148116. [Epub ahead of print]
Epub:
Yes
Abstract:
Hypocretin/orexin (HCRT) and melanin concentrating hormone (MCH) neuropeptides are exclusively produced by the lateral...
Link:
https://www.pnas.org/content/early/2019/08/01/1902148116
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Seifinejad A, Li S, Mikhail C, Vassalli A, Pradervand S, Arribat Y, Pezeshgi Modarres H, Allen B, John RM, Amati F, Tafti M. Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proc Natl Acad Sci U S A. 2019 Aug 2. pii: 201902148. doi: 10.1073/pnas.1902148116. [Epub ahead of print].

Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation

Authors:
Jiang D, Jiang Z, Lu D, Wang X, Liang H, Zhang J, Meng Y, Li Y, Wu D, Huang Y, Chen Y, Deng H, Wu Q, Xiong J, Meng A, Yu L
Citation:
Nat Cell Biol. 2019 Aug;21(8):966-977. doi: 10.1038/s41556-019-0358-6. Epub 2019 Aug 1
Epub:
Not Epub
Abstract:
Migrasomes are recently identified vesicular organelles that form on retraction fibres behind migrating cells. Whether...
Link:
https://www.nature.com/articles/s41556-019-0358-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiang D, Jiang Z, Lu D, Wang X, Liang H, Zhang J, Meng Y, Li Y, Wu D, Huang Y, Chen Y, Deng H, Wu Q, Xiong J, Meng A, Yu L. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol. 2019 Aug;21(8):966-977. doi: 10.1038/s41556-019-0358-6. Epub 2019 Aug 1.

Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants

Authors:
Santos JMA, Mendes-Silva L, Afonso V, Martins G, Machado RSR, Lopes JA, Cancela L, Futschik ME, Sachinidis A, Gavaia P, Bragança J
Citation:
Cell Death Dis. 2019 Aug 5;10(8):582. doi: 10.1038/s41419-019-1816-6
Epub:
Not Epub
Abstract:
Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse,...
Link:
https://www.nature.com/articles/s41419-019-1816-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Santos JMA, Mendes-Silva L, Afonso V, Martins G, Machado RSR, Lopes JA, Cancela L, Futschik ME, Sachinidis A, Gavaia P, Bragança J. Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants. Cell Death Dis. 2019 Aug 5;10(8):582. doi: 10.1038/s41419-019-1816-6.

Early expression of Tubulin Beta-III in avian cranial neural crest cells

Authors:
Chacon J, Rogers CD
Citation:
Gene Expr Patt. 2019;[Epub ahead of print] doi:10.1016/j.gep.2019.119067
Epub:
Yes
Abstract:
Neural crest cells are a transient stem-like cell population that forms in the dorsal neural tube of vertebrate embryos and...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1567133X19300675
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Chacon J, Rogers CD. Early expression of Tubulin Beta-III in avian cranial neural crest cells. Gene Expr Patt. 2019;[Epub ahead of print] doi:10.1016/j.gep.2019.119067.

Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus

Authors:
Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N
Citation:
Front Genet. 2019;10:693. doi:10.3389/fgene.2019.00693
Epub:
Not Epub
Abstract:
Type 2 diabetes mellitus (T2DM) is characterized by persistent hyperglycemia and is influenced by genetic and environmental...
Link:
https://www.frontiersin.org/articles/10.3389/fgene.2019.00693/full
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N. Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus. Front Genet. 2019;10:693. doi:10.3389/fgene.2019.00693.

FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation

Authors:
Fischer P, Chen H, Pacho F, Rieder D, Kimmel RA, Meyer D
Citation:
BMC Biol. 2019 Jul 30;17(1):61. doi: 10.1186/s12915-019-0683-z
Epub:
Not Epub
Abstract:
BACKGROUND: FoxH1 is a forkhead transcription factor with conserved key functions in vertebrate mesoderm induction and left-...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0683-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fischer P, Chen H, Pacho F, Rieder D, Kimmel RA, Meyer D. FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation. BMC Biol. 2019 Jul 30;17(1):61. doi: 10.1186/s12915-019-0683-z.

TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis

Authors:
Ogata S, Morokuma J, Hayata T, Kolle G, Niehrs C, Ueno N, Cho KW
Citation:
Genes Dev. 2007 Jul 15;21(14):1817-31
Epub:
Not Epub
Abstract:
The molecular mechanisms governing the cell behaviors underlying morphogenesis remain a major focus of research in both...
Link:
http://genesdev.cshlp.org/content/21/14/1817.long
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ogata S, Morokuma J, Hayata T, Kolle G, Niehrs C, Ueno N, Cho KW. TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis. Genes Dev. 2007 Jul 15;21(14):1817-31.

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