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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12390 scientific papers returned from the database with the search filters currently being used below.

A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

Authors:
Chen T, Zhang B, Ziegenhals T, Prusty AB, Fröhler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W
Citation:
PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460
Epub:
Not Epub
Abstract:
Malfunction of pre-mRNA processing factors are linked to several human diseases including cancer and neurodegeneration. Here we...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008460
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen T, Zhang B, Ziegenhals T, Prusty AB, Fröhler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460.

Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1

Authors:
Thomas C, Levasseur MD, Harris RJ, Davies OR, Madgwick S
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/824763
Epub:
Not Epub
Abstract:
Successful cell division relies on the faithful segregation of chromosomes. If chromosomes segregate prematurely the cell is at...
Link:
https://www.biorxiv.org/content/10.1101/824763v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Thomas C, Levasseur MD, Harris RJ, Davies OR, Madgwick S. Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1. bioRxiv. 2019;[preprint] doi:10.1101/824763 .

Short-wavelength violet light (420nm) stimulates melanopsin-dependent acute alertness responses in zebrafish

Authors:
Contreras JE, Lisse TS, Bouzidi C, Cavanaugh AM, Matynia A, Rieger S
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/825257
Epub:
Not Epub
Abstract:
Sunlight throughout the day and seasons strongly influences our biological rhythms and activity. In recent years, it has become...
Link:
https://www.biorxiv.org/content/10.1101/825257v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Contreras JE, Lisse TS, Bouzidi C, Cavanaugh AM, Matynia A, Rieger S. Short-wavelength violet light (420nm) stimulates melanopsin-dependent acute alertness responses in zebrafish. bioRxiv. 2019;[preprint] doi:10.1101/825257.

ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation

Authors:
Graham JB, Sunryd JC, Mathavan K, Weir E, Larsen ISB, Halim A, Clausen H, Cousin H, Alfandari D, Hebert DN
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/822270
Epub:
Not Epub
Abstract:
Protein glycosylation plays essential roles in protein structure, stability and activity such as cell adhesion. The cadherin...
Link:
https://www.biorxiv.org/content/10.1101/822270v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Graham JB, Sunryd JC, Mathavan K, Weir E, Larsen ISB, Halim A, Clausen H, Cousin H, Alfandari D, Hebert DN. ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation. bioRxiv. 2019;[preprint] doi:10.1101/822270.

Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing

Authors:
McIntosh CS, Aung-Htut MT, Fletcher S, Wilton SD
Citation:
Int J Mol Sci. 2019;20(21):5434. doi:10.3390/ijms20215434
Epub:
Not Epub
Abstract:
Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor...
Link:
https://www.mdpi.com/1422-0067/20/21/5434/htm
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: SCA3 patient-derived dermal fibroblasts
Citation Extract:
McIntosh CS, Aung-Htut MT, Fletcher S, Wilton SD. Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing. Int J Mol Sci. 2019;20(21):5434. doi:10.3390/ijms20215434.

Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation

Authors:
Oprişoreanu A-M, Smith HL, Arya S, Webster R, Zhong Z, Wehner D, Cardozo MJ, Becker T, Talbot K, Becker CG
Citation:
Cell Rep. 2019;29:1082-98. doi:10.1016/j.celrep.2019.09.033
Epub:
Not Epub
Abstract:
Chondrolectin (Chodl) is needed for motor axon extension in zebrafish and is dysregulated in mouse models of spinal muscular...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31221-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oprişoreanu A-M, Smith HL, Arya S, Webster R, Zhong Z, Wehner D, Cardozo MJ, Becker T, Talbot K, Becker CG. Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation. Cell Rep. 2019;29:1082-98. doi:10.1016/j.celrep.2019.09.033.

Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo

Authors:
Liu B, Satou Y
Citation:
Nat Comm. 2019;10:4911 doi:10.1038/s41467-019-12839-6
Epub:
Not Epub
Abstract:
Foxg constitutes a regulatory loop with Fgf8 and plays an important role in the development of anterior placodes and the...
Link:
https://www.nature.com/articles/s41467-019-12839-6
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (AKA C. intestinalis; ascidian)
Citation Extract:
Liu B, Satou Y. Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo. Nat Comm. 2019;10:4911 doi:10.1038/s41467-019-12839-6.

Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation

Authors:
Puzik K, Tonnier V, Opper I, Eckert A, Zhou L, Kratzer M-C, le Noble F, Nienhaus GU, Gradl D
Citation:
Sci Rep. 2019;9:15645 doi:10.1038/s41598-019-52218-1
Epub:
Not Epub
Abstract:
The activation of distinct branches of the Wnt signaling network is essential for regulating early vertebrate development....
Link:
https://www.nature.com/articles/s41598-019-52218-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Puzik K, Tonnier V, Opper I, Eckert A, Zhou L, Kratzer M-C, le Noble F, Nienhaus GU, Gradl D. Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation. Sci Rep. 2019;9:15645 doi:10.1038/s41598-019-52218-1.

MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer

Authors:
Duan F-G, Wang M-F, Cao Y-B, Li D, Li R-Z, Fan X-X, Khan I, Lai H-L, Zhang Y-Z, Hsiao WW-L, Yao X-J, Wu Q-B, Liu L, Tang I-J, Leung EL-H
Citation:
Cell Death Dis. 2019;10:821. doi:10.1038/s41419-019-2031-1
Epub:
Not Epub
Abstract:
MicroRNAs regulate post-transcriptional gene expression and play important roles in multiple cellular processes. In this study...
Link:
https://www.nature.com/articles/s41419-019-2031-1
Delivery Method:
intratumoral injection
Organism or Cell Type:
cell culture: human NSCLC A549; mouse xenograft
Citation Extract:
Duan F-G, Wang M-F, Cao Y-B, Li D, Li R-Z, Fan X-X, Khan I, Lai H-L, Zhang Y-Z, Hsiao WW-L, Yao X-J, Wu Q-B, Liu L, Tang I-J, Leung EL-H. MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer. Cell Death Dis. 2019;10:821. doi:10.1038/s41419-019-2031-1.

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors

Authors:
He M, Zhang R, Zhang F, Jiao S, Ye D, Wang H, Sun Y
Citation:
bioRxiv. 2019;[preprint] doi:/10.1101/821702
Epub:
Not Epub
Abstract:
Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly...
Link:
https://www.biorxiv.org/content/10.1101/821702v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
He M, Zhang R, Zhang F, Jiao S, Ye D, Wang H, Sun Y. Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. bioRxiv. 2019;[preprint] doi:/10.1101/821702 .

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