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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts

Authors:
Ambady P, Wu YJ, Kersch CN, Walker JM, Holland S, Muldoon LL, Neuwelt EA
Citation:
Cancer Gene Ther. 2021;[Epub]. doi:10.1038/s41417-021-00324-6
Epub:
Not Epub
Abstract:
Overexpression of O6-methylguanine DNA methyltransferase (MGMT) contributes to resistance to chemo-radiation therapy (CRT) in...
Link:
https://www.nature.com/articles/s41417-021-00324-6
Delivery Method:
radiation
Organism or Cell Type:
rats with brain tumor xenografts
Citation Extract:
Ambady P, Wu YJ, Kersch CN, Walker JM, Holland S, Muldoon LL, Neuwelt EA. Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts. Cancer Gene Ther. 2021;[Epub]. doi:10.1038/s41417-021-00324-6.

Rab35 regulates skeletogenesis and gastrulation by facilitating actin remodeling and vesicular trafficking

Authors:
Remsburg C, Testa M, Song JL
Citation:
Cells Dev. 2021 Mar;165:203660. doi:10.1016/j.cdev.2021.203660. Epub 2021 Feb 8
Epub:
Not Epub
Abstract:
Rab35 is a small GTPase that regulates plasma membrane to early endosome vesicular trafficking and mediates actin remodeling to...
Link:
https://www.sciencedirect.com/science/article/pii/S2667290121000073
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Remsburg C, Testa M, Song JL. Rab35 regulates skeletogenesis and gastrulation by facilitating actin remodeling and vesicular trafficking. Cells Dev. 2021 Mar;165:203660. doi:10.1016/j.cdev.2021.203660. Epub 2021 Feb 8.

Novel pre-clinical model for CDKL5 Deficiency Disorder

Authors:
Serrano RJ, Lee C, Bryson-Richardson RJ, Sztal TE
Citation:
bioRxiv. 2021;[preprint] doi: https://doi.org/10.1101/2021.04.07.438335
Epub:
Not Epub
Abstract:
Cyclin-dependent kinase-like-5 (CDKL5) Deficiency Disorder (CDD) is a severe X-linked neurodegenerative disease characterized...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.07.438335v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Serrano RJ, Lee C, Bryson-Richardson RJ, Sztal TE. Novel pre-clinical model for CDKL5 Deficiency Disorder. bioRxiv. 2021;[preprint] doi: https://doi.org/10.1101/2021.04.07.438335.

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

Authors:
Laghi V, Rezelj V, Boucontet L, Frétaud M, Da Costa B, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud JP
Citation:
Front Cell Infect Microbiol. 2022 Mar 11;12:790851. doi: 10.3389/fcimb.2022.790851. PMID: 35360100; PMCID: PMC8963489.
Epub:
Not Epub
Abstract:
Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other...
Link:
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.790851/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Laghi V, Rezelj V, Boucontet L, Frétaud M, Da Costa B, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud JP. Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder. Front Cell Infect Microbiol. 2022 Mar 11;12:790851. doi: 10.3389/fcimb.2022.790851. PMID: 35360100; PMCID: PMC8963489..

Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration

Authors:
Geng F, Ma J, Li X, Hu Z, Zhang R
Citation:
Int J Mol Sci. 2021;22(8):3945. doi:10.3390/ijms22083945
Epub:
Not Epub
Abstract:
Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly regenerate injured hearts and are...
Link:
https://www.mdpi.com/1422-0067/22/8/3945/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geng F, Ma J, Li X, Hu Z, Zhang R. Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration. Int J Mol Sci. 2021;22(8):3945. doi:10.3390/ijms22083945.

Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models

Authors:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439067
Epub:
Not Epub
Abstract:
The majority of kidney diseases arise from the loss of podocytes and from morphological changes of their highly complex foot...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.09.439067v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N. Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439067 .

Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis

Authors:
Adar-Levor S, Nachmias D, Gal-Oz ST, Jahn YM, Peyrieras N, Zaritsky A, Birnbaum RY, Elia N
Citation:
Proc Nat Acad Sci USA. 2021;118(15):e2021210118. doi:10.1073/pnas.2021210118
Epub:
Not Epub
Abstract:
Animal cytokinesis ends with the formation of a thin intercellular membrane bridge that connects the two newly formed sibling...
Link:
https://www.pnas.org/content/118/15/e2021210118
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Adar-Levor S, Nachmias D, Gal-Oz ST, Jahn YM, Peyrieras N, Zaritsky A, Birnbaum RY, Elia N. Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis. Proc Nat Acad Sci USA. 2021;118(15):e2021210118. doi:10.1073/pnas.2021210118.

Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation

Authors:
Li N, Zhou P, Yang M, Fang X, Krämer N, Mughal TA, Abbasi AA, Yang Y, Kaindl AM, Hu H
Citation:
Clin Genet. 2021 Apr 9. doi: 10.1111/cge.13965. Online ahead of print
Epub:
Yes
Abstract:
RAPGEF1 is a guanine nucleotide exchange factor responsible for transmitting extracellular signals to the Ras family of GTPase...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/cge.13965
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li N, Zhou P, Yang M, Fang X, Krämer N, Mughal TA, Abbasi AA, Yang Y, Kaindl AM, Hu H. Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation. Clin Genet. 2021 Apr 9. doi: 10.1111/cge.13965. Online ahead of print.

Endothelial struts enable the generation of large lumenized blood vessels de novo

Authors:
Weijts B, Shaked I, Ginsberg M, Kleinfeld D, Robin C, Traver D
Citation:
Nat Cell Biol. 2021;23(4):322-329. doi:10.1038/s41556-021-00664-3
Epub:
Not Epub
Abstract:
De novo blood vessel formation occurs through coalescence of endothelial cells (ECs) into a cord-like structure, followed by...
Link:
https://www.nature.com/articles/s41556-021-00664-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Weijts B, Shaked I, Ginsberg M, Kleinfeld D, Robin C, Traver D. Endothelial struts enable the generation of large lumenized blood vessels de novo. Nat Cell Biol. 2021;23(4):322-329. doi:10.1038/s41556-021-00664-3.

BMP heterodimers signal via distinct type I receptor class functions

Authors:
Tajer B, Dutko JA, Little SC, Mullins MC
Citation:
Proc Nat Acad Sci USA. 2021;118(15):e2017952118. doi:10.1073/pnas.2017952118
Epub:
Not Epub
Abstract:
Heterodimeric TGF-β ligands outperform homodimers in a variety of developmental, cell culture, and therapeutic contexts;...
Link:
https://www.pnas.org/content/118/15/e2017952118.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tajer B, Dutko JA, Little SC, Mullins MC. BMP heterodimers signal via distinct type I receptor class functions. Proc Nat Acad Sci USA. 2021;118(15):e2017952118. doi:10.1073/pnas.2017952118.

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