You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast

Authors:
Yuan X, Qin Y, Wang J, Fan C
Citation:
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 19:109053. doi: 10.1016/j.cbpc.2021.109053
Epub:
Yes
Abstract:
Ototoxicity of drugs is an important inducement for hearing loss. Anisomycin is a candidate drug for parasite, cancer,...
Link:
https://pubmed.ncbi.nlm.nih.gov/33887477/
Organism or Cell Type:
zebrafish
Citation Extract:
Yuan X, Qin Y, Wang J, Fan C. Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 19:109053. doi: 10.1016/j.cbpc.2021.109053.

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

Authors:
Gudiño V, Pohl SÖ, Billard CV, Cammareri P, Bolado A, Aitken S, Stevenson D, Hall AE, Agostino M, Cassidy J, Nixon C, von Kriegsheim A, Freile P, Popplewell L, Dickson G, Murphy L, Wheeler A, Dunlop M, Din F, Strathdee D, Sansom OJ, Myant KB
Citation:
Nat Commun. 2021 Apr 20;12(1):2335. doi:10.1038/s41467-021-22531-3
Epub:
Not Epub
Abstract:
Current therapeutic options for treating colorectal cancer have little clinical efficacy and acquired resistance during...
Link:
https://www.nature.com/articles/s41467-021-22531-3
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: CMT93 cells; human organoids
Citation Extract:
Gudiño V, Pohl SÖ, Billard CV, Cammareri P, Bolado A, Aitken S, Stevenson D, Hall AE, Agostino M, Cassidy J, Nixon C, von Kriegsheim A, Freile P, Popplewell L, Dickson G, Murphy L, Wheeler A, Dunlop M, Din F, Strathdee D, Sansom OJ, Myant KB. RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nat Commun. 2021 Apr 20;12(1):2335. doi:10.1038/s41467-021-22531-3.

Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating

Authors:
Zhao L, Xie H, Kang Y, Lin Y, Liu G, Sakato-Antoku M, Patel-King RS, Wang B, Wan C, King SM, Zhao C, Huang K
Citation:
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2015689118. doi: 10.1073/pnas.2015689118
Epub:
Not Epub
Abstract:
Coordinated beating is crucial for the function of multiple cilia. However, the molecular mechanism is poorly understood. Here...
Link:
https://www.pnas.org/content/118/17/e2015689118.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao L, Xie H, Kang Y, Lin Y, Liu G, Sakato-Antoku M, Patel-King RS, Wang B, Wan C, King SM, Zhao C, Huang K. Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2015689118. doi: 10.1073/pnas.2015689118.

Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5

Authors:
Jacinto R, Sampaio P, Roxo-Rosa M, Pestana S, Lopes SS
Citation:
Front Cell Dev Biol. 2021 Apr 1;9:624531. doi: 10.3389/fcell.2021.624531. eCollection 2021
Epub:
Not Epub
Abstract:
The left-right (LR) field recognizes the importance of the mechanism involving the calcium permeable channel Polycystin-2....
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2021.624531/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jacinto R, Sampaio P, Roxo-Rosa M, Pestana S, Lopes SS. Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Front Cell Dev Biol. 2021 Apr 1;9:624531. doi: 10.3389/fcell.2021.624531. eCollection 2021.

A 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract

Authors:
Jones JL, Corbett MA, Yeaman E, Zhao D, Gecz J, Gasperini RJ, Charlesworth JC, Mackey DA, Elder JE, Craig JE, Burdon KP
Citation:
Eur J Hum Genet. 2021;[Epub] doi:10.1038/s41431-021-00889-8
Epub:
Not Epub
Abstract:
Inherited paediatric cataract is a rare Mendelian disease that results in visual impairment or blindness due to a clouding of...
Link:
https://www.nature.com/articles/s41431-021-00889-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jones JL, Corbett MA, Yeaman E, Zhao D, Gecz J, Gasperini RJ, Charlesworth JC, Mackey DA, Elder JE, Craig JE, Burdon KP . A 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract. Eur J Hum Genet. 2021;[Epub] doi:10.1038/s41431-021-00889-8.

Molecular mechanisms of hearing loss in Nager syndrome

Authors:
Maharana SK, Saint-Jeannet JP
Citation:
Dev Biol. 2021 Apr 14:S0012-1606(21)00097-X. doi: 10.1016/j.ydbio.2021.04.002. Online ahead of print
Epub:
Not Epub
Abstract:
Nager syndrome is a rare human developmental disorder characterized by hypoplastic neural crest-derived craniofacial bones and...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S001216062100097X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Maharana SK, Saint-Jeannet JP. Molecular mechanisms of hearing loss in Nager syndrome. Dev Biol. 2021 Apr 14:S0012-1606(21)00097-X. doi: 10.1016/j.ydbio.2021.04.002. Online ahead of print.

Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish

Authors:
Inoue M, Miyahara H, Shiraishi H, Shimizu N, Tsumori M, Kiyota K, Maeda M, Umeda R, Ishitani T, Hanada R, Ihara K, Hanada T
Citation:
Sci Rep. 2021;11:8392. doi:10.1038/s41598-021-87879-4
Epub:
Not Epub
Abstract:
Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to...
Link:
https://www.nature.com/articles/s41598-021-87879-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Inoue M, Miyahara H, Shiraishi H, Shimizu N, Tsumori M, Kiyota K, Maeda M, Umeda R, Ishitani T, Hanada R, Ihara K, Hanada T. Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish. Sci Rep. 2021;11:8392. doi:10.1038/s41598-021-87879-4.

Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy

Authors:
Bonora E, Chakrabarty S, Kellaris G, Tsutsumi M, Bianco F, Bergamini C, Ullah F, Isidori F, Liparulo I, Diquigiovanni C, Masin L, Rizzardi N, Cratere MG, Boschetti E, Papa V, Maresca A, Cenacchi G, Casadio R, Martelli P, Matera I, Ceccherini I, Fato R, Raiola G, Arrigo S, Signa S, Sementa AR, Severino M, Striano P, Fiorillo C, Goto T, Uchino S, Oyazato Y, Nakamura H, Mishra SK, Yeh YS, Kato T, Nozu K, Tanboon J, Morioka I, Nishino I, Toda T, Goto YI, Ohtake A, Kosaki K, Yamaguchi Y, Nonaka I, Iijima K, Mimaki M, Kurahashi H, Raams A, MacInnes A, Alders M, Engelen M, Linthorst G, de Koning T, den Dunnen W, Dijkstra G, van Spaendonck K, van Gent DC, Aronica EM, Picco P, Carelli V, Seri M, Katsanis N, Duijkers FAM, Taniguchi-Ikeda M, De Giorgio R
Citation:
Brain. 2021 Apr 15:awab056. doi: 10.1093/brain/awab056. Online ahead of print
Epub:
Yes
Abstract:
Abnormal gut motility is a feature of several mitochondrial encephalomyopathies, and mutations in genes such as TYMP and POLG,...
Link:
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab056/6224919
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bonora E, Chakrabarty S, Kellaris G, Tsutsumi M, Bianco F, Bergamini C, Ullah F, Isidori F, Liparulo I, Diquigiovanni C, Masin L, Rizzardi N, Cratere MG, Boschetti E, Papa V, Maresca A, Cenacchi G, Casadio R, Martelli P, Matera I, Ceccherini I, Fato R, Raiola G, Arrigo S, Signa S, Sementa AR, Severino M, Striano P, Fiorillo C, Goto T, Uchino S, Oyazato Y, Nakamura H, Mishra SK, Yeh YS, Kato T, Nozu K, Tanboon J, Morioka I, Nishino I, Toda T, Goto YI, Ohtake A, Kosaki K, Yamaguchi Y, Nonaka I, Iijima K, Mimaki M, Kurahashi H, Raams A, MacInnes A, Alders M, Engelen M, Linthorst G, de Koning T, den Dunnen W, Dijkstra G, van Spaendonck K, van Gent DC, Aronica EM, Picco P, Carelli V, Seri M, Katsanis N, Duijkers FAM, Taniguchi-Ikeda M, De Giorgio R. Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy. Brain. 2021 Apr 15:awab056. doi: 10.1093/brain/awab056. Online ahead of print.

Alternative splicing is a developmental switch for hTERT expression

Authors:
Penev A, Bazley A, Shen M, Boeke JD, Savage SA, Sfeir A
Citation:
Molec Cell. 2021;[Epub ahead of print]. doi:10.1016/j.molcel.2021.03.033
Epub:
Yes
Abstract:
Telomere length control is critical for cellular lifespan and tumor suppression. Telomerase is transiently activated in the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1097276521002288
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Penev A, Bazley A, Shen M, Boeke JD, Savage SA, Sfeir A. Alternative splicing is a developmental switch for hTERT expression. Molec Cell. 2021;[Epub ahead of print]. doi:10.1016/j.molcel.2021.03.033.

The connectome of neural crest enhancers reveals regulatory features of signaling systems

Authors:
Azambuja AP, Simoes-Costa M
Citation:
Dev Cell. 2021;56:1-15. doi:10.1016/j.devcel.2021.03.024
Epub:
Not Epub
Abstract:
Cell fate commitment is controlled by cis-regulatory elements often located in remote regions of the genome. To examine the...
Link:
https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(21)00264-1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Azambuja AP, Simoes-Costa M. The connectome of neural crest enhancers reveals regulatory features of signaling systems. Dev Cell. 2021;56:1-15. doi:10.1016/j.devcel.2021.03.024.

Pages