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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12365 scientific papers returned from the database with the search filters currently being used below.

Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish

Authors:
Grossi I, Schiavone M, Cannone E, Grejdan OA, Tobia C, Bonomini F, Rezzani R, Salvi A, De Petro G
Citation:
Genes. 2023;14(1):35. doi:10.3390/genes14010035
Epub:
Not Epub
Abstract:
The LIM and SH3 domain protein 1 (LASP1) was originally identified in metastatic breast cancer and mainly characterized as a...
Link:
https://www.mdpi.com/2073-4425/14/1/35
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Grossi I, Schiavone M, Cannone E, Grejdan OA, Tobia C, Bonomini F, Rezzani R, Salvi A, De Petro G. Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish. Genes. 2023;14(1):35. doi:10.3390/genes14010035.

Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish

Authors:
Ma J, Gu Y, Liu J, Song J, Zhou T, Jiang M, Wen Y, Guo X, Zhou Z, Sha J, He J, Hu Z, Luo L, Liu M
Citation:
Cell Mol Life Sci. 2022 Dec 27;80(1):19. doi: 10.1007/s00018-022-04669-5
Epub:
Not Epub
Abstract:
Congenital heart disease (CHD) is the most common birth defect worldwide and a main cause of perinatal and infant mortality....
Link:
https://link.springer.com/article/10.1007/s00018-022-04669-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma J, Gu Y, Liu J, Song J, Zhou T, Jiang M, Wen Y, Guo X, Zhou Z, Sha J, He J, Hu Z, Luo L, Liu M. Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cell Mol Life Sci. 2022 Dec 27;80(1):19. doi: 10.1007/s00018-022-04669-5.

Phosphorylation of adducin-1 by TPX2 promotes interpolar microtubule homeostasis and precise chromosome segregation in mouse oocytes

Authors:
Zhang Y, Fan B, Li X, Tang Y, Shao J, Liu L, Ren Y, Yang Y, Xu B
Citation:
Cell Biosci. 2022 Dec 20;12(1):205. doi: 10.1186/s13578-022-00943-y
Epub:
Not Epub
Abstract:
Background: ADD1 (adducin-1) and TPX2 (targeting protein for Xklp2) are centrosomal proteins and regulate mitotic spindle...
Link:
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-022-00943-y
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhang Y, Fan B, Li X, Tang Y, Shao J, Liu L, Ren Y, Yang Y, Xu B. Phosphorylation of adducin-1 by TPX2 promotes interpolar microtubule homeostasis and precise chromosome segregation in mouse oocytes. Cell Biosci. 2022 Dec 20;12(1):205. doi: 10.1186/s13578-022-00943-y.

Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development

Authors:
Lian Z, Wu Z, Gu R, Wang Y, Wu C, Cheng Z, He M, Wang Y, Cheng Y, Gu HF
Citation:
Cells. 2022 Dec 7;11(24):3946. doi: 10.3390/cells11243946
Epub:
Not Epub
Abstract:
Folic acid (FA) is a synthetic and highly stable version of folate, while 6S-5-methyltetrahydrofolate is the predominant form...
Link:
https://www.mdpi.com/2073-4409/11/24/3946
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lian Z, Wu Z, Gu R, Wang Y, Wu C, Cheng Z, He M, Wang Y, Cheng Y, Gu HF. Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development. Cells. 2022 Dec 7;11(24):3946. doi: 10.3390/cells11243946.

Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro

Authors:
Ghosh U, Gupta S, Sinha S
Citation:
Bioconjugate Chem. 2023;34(1):174-80 doi:10.1021/acs.bioconjchem.2c00587
Epub:
Not Epub
Abstract:
Thiol functionalized oligonucleotides are useful intermediates for a wide range of applications including DNA nanobiotechnology...
Link:
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00587
Delivery Method:
IGT-linked
Organism or Cell Type:
cell culture: MCF7
Citation Extract:
Ghosh U, Gupta S, Sinha S. Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro. Bioconjugate Chem. 2023;34(1):174-80 doi:10.1021/acs.bioconjchem.2c00587.

Evi5 is required for Xenopus limb and tail regeneration

Authors:
Yang L, Chen Y, Liu H, Liu Y, Yuan F, Li Q, Lin G
Citation:
Front Cell Dev Biol. 2022;10:1027666. doi:10.3389/fcell.2022.1027666
Epub:
Not Epub
Abstract:
Amphibians such as salamanders and the African clawed frog Xenopus are great models for regeneration studies because they can...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2022.1027666/full
Delivery Method:
microinjection and electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Yang L, Chen Y, Liu H, Liu Y, Yuan F, Li Q, Lin G. Evi5 is required for Xenopus limb and tail regeneration. Front Cell Dev Biol. 2022;10:1027666. doi:10.3389/fcell.2022.1027666.

The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma

Authors:
Taylor W, Deschamps S, Reboutier D, Paillard L, Méreau A, Audic Y
Citation:
Cancer Research Comm. 2022;2(12):1669-83. doi:10.1158/2767-9764.CRC-22-0350
Epub:
Not Epub
Abstract:
The TP63 gene encodes the p63 transcription factor. It is frequently amplified or overexpressed in squamous cell carcinomas....
Link:
https://aacrjournals.org/cancerrescommun/article/2/12/1669/711751/The-Splicing-Factor-PTBP1-Represses-TP63-Isoform
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Taylor W, Deschamps S, Reboutier D, Paillard L, Méreau A, Audic Y. The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma. Cancer Research Comm. 2022;2(12):1669-83. doi:10.1158/2767-9764.CRC-22-0350.

AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1--Dicer-1--mir-122 hierarchy

Authors:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M
Citation:
Front Cell Infect Microbiol. 2022;12:1011386. doi:10.3389/fcimb.2022.1011386
Epub:
Not Epub
Abstract:
Introduction and objective: Cholesterol homeostasis is a culmination of cellular synthesis, efflux, and catabolism to important...
Link:
https://www.frontiersin.org/articles/10.3389/fcimb.2022.1011386/full
Delivery Method:
GMO-PMO i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M. AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1--Dicer-1--mir-122 hierarchy. Front Cell Infect Microbiol. 2022;12:1011386. doi:10.3389/fcimb.2022.1011386.

Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions

Authors:
Templehof H, Moshe N, Avraham-Davidi I, Yaniv K
Citation:
JCI Insight. 2021 Jul 8;6(13):e130399. doi: 10.1172/jci.insight.130399
Epub:
Not Epub
Abstract:
Apolipoprotein B (ApoB) is the primary protein of chylomicrons, VLDLs, and LDLs and is essential for their production. Defects...
Link:
https://insight.jci.org/articles/view/130399
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Templehof H, Moshe N, Avraham-Davidi I, Yaniv K. Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions. JCI Insight. 2021 Jul 8;6(13):e130399. doi: 10.1172/jci.insight.130399.

Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis

Authors:
Fetsko AR, Sebo DJ, Taylor MR
Citation:
Dev Biol. 2022 Dec 8:S0012-1606(22)00218-4. doi: 10.1016/j.ydbio.2022.11.007. Online ahead of print
Epub:
Yes
Abstract:
During neurovascular development, brain endothelial cells (BECs) respond to secreted signals from the neuroectoderm that...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160622002184
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fetsko AR, Sebo DJ, Taylor MR. Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis. Dev Biol. 2022 Dec 8:S0012-1606(22)00218-4. doi: 10.1016/j.ydbio.2022.11.007. Online ahead of print.

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