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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12364 scientific papers returned from the database with the search filters currently being used below.
There are 12364 scientific papers returned from the database with the search filters currently being used below.
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects
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Citation:
Nucleic Acids Res. 2022;gkac1108 doi:10.1093/nar/gkac1108 Epub:
Yes Abstract:
Friedreich’s ataxia is an incurable disease caused by frataxin (FXN) protein deficiency, which is mostly induced by GAA repeat... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: 293T Citation Extract: Wang F, Calvo-Roitberg E, Rembetsy-Brown JM, Fang M, Sousa J, Kartje ZJ, Krishnamurthy PM, Lee J, Green MR, Pai AA, Watts JK. G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic Acids Res. 2022;gkac1108 doi:10.1093/nar/gkac1108. |
gldc Is Essential for Renal Progenitor Patterning during Kidney Development
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Citation:
Biomedicines. 2022;10(12):3220. doi:10.3390/biomedicines10123220 Epub:
Not Epub Abstract:
The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane that is responsible for regulating glycine... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Weaver NE, Healy A, Wingert RA. gldc Is Essential for Renal Progenitor Patterning during Kidney Development. Biomedicines. 2022;10(12):3220. doi:10.3390/biomedicines10123220. |
GTP-Binding Protein 1-Like (GTPBP1l) Regulates Vascular Patterning during Zebrafish Development
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Citation:
Biomedicines. 2022;10(12):3208. doi:10.3390/biomedicines10123208 Epub:
Not Epub Abstract:
Genetic regulation of vascular patterning is not fully understood. Here, we report a novel gene, gtpbp1l (GTP-binding protein 1... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lo Y-H, Huang Y-S, Chang Y-C, Hung P-Y, Wang W-D, Liu W, Urade R, Wen Z-H, Wu C-Y. GTP-Binding Protein 1-Like (GTPBP1l) Regulates Vascular Patterning during Zebrafish Development. Biomedicines. 2022;10(12):3208. doi:10.3390/biomedicines10123208. |
Disruption of fos causes craniofacial anomalies in developing zebrafish
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.12.06.519379 Epub:
Not Epub Abstract:
Craniofacial development is a complex and tightly regulated process and disruptions can lead to structural birth defects, the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Maili L, Tandon B, Yuan Q, Menezes S, Hashmi SS, Letra A, Eisenhoffer GT, Hecht JT. Disruption of fos causes craniofacial anomalies in developing zebrafish. bioRxiv. 2022;[preprint] doi:10.1101/2022.12.06.519379. |
Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development
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Citation:
EMBO J. 2022 Dec 7:e111364. doi: 10.15252/embj.2022111364. Online ahead of print Epub:
Yes Abstract:
Early embryonic development depends on proper utilization and clearance of maternal transcriptomes. How these processes are... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Xiao Y, Chen J, Yang S, Sun H, Xie L, Li J, Jing N, Zhu X. Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development. EMBO J. 2022 Dec 7:e111364. doi: 10.15252/embj.2022111364. Online ahead of print. |
Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis
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Citation:
Development. 2022 Dec 1;149(23):dev200754. doi: 10.1242/dev.200754. Epub 2022 Dec 5. PMID: 36468454 Epub:
Not Epub Abstract:
Developmentally, the great vessels of the heart originate from the pharyngeal arch arteries (PAAs). During PAA vasculogenesis,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Liu J, Zhang M, Dong H, Liu J, Mao A, Ning G, Cao Y, Zhang Y, Wang Q. Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis. Development. 2022 Dec 1;149(23):dev200754. doi: 10.1242/dev.200754. Epub 2022 Dec 5. PMID: 36468454. |
Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling
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Citation:
Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2201097119. doi: 10.1073/pnas.2201097119. Epub 2022 Dec 5 Epub:
Not Epub Abstract:
Despite the robust healing capacity of the liver, regenerative failure underlies numerous hepatic diseases, including the JAG1... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhao C, Matalonga J, Lancman JJ, Liu L, Xiao C, Kumar S, Gates KP, He J, Graves A, Huisken J, Azuma M, Lu Z, Chen C, Ding BS, Dong PDS. Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2201097119. doi: 10.1073/pnas.2201097119. Epub 2022 Dec 5. |
A Missense Variant in PDK1 Associated with Severe Neurodevelopmental Delay and Epilepsy
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Citation:
Biomedicines. 2022;10(12):3171. doi:10.3390/biomedicines10123171 Epub:
Not Epub Abstract:
The pyruvate dehydrogenase complex (PDC) is responsible for the conversion of pyruvate into acetyl-CoA, which is used for... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vaz R, Wincent J, Elfissi N, Rosengren Forsblad K, Pettersson M, Naess K, Wedell A, Wredenberg A, Lindstrand A, Ygberg S. A Missense Variant in PDK1 Associated with Severe Neurodevelopmental Delay and Epilepsy. Biomedicines. 2022;10(12):3171. doi:10.3390/biomedicines10123171 . |
CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII
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Citation:
Blood Adv. 2023 Mar 14;7(5):697-711. doi: 10.1182/bloodadvances.2022009014. PMID: 36477543; PMCID: PMC9984962 Epub:
Not Epub Abstract:
Emerging gene therapy clinical trials test the correction of hemophilia A (HA) by replacing factor VIII (FVIII) in autologous... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Elnaggar M, Al-Mohannadi A, Hasan W, Abdelrahman D, Al-Kubaisi MJ, Pavlovski I, Gentilcore G, Sathappan A, Kizhakayil D, Ali AI, Mohan S, Olagunju D, Cugno C, Grivel JC, Borsotti C, Follenzi A, Da'as SI, Deola S. CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII. Blood Adv. 2023 Mar 14;7(5):697-711. doi: 10.1182/bloodadvances.2022009014. PMID: 36477543; PMCID: PMC9984962. |
Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration
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Citation:
Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211690119. doi: 10.1073/pnas.2211690119. Epub 2022 Dec 5 Epub:
Not Epub Abstract:
In the zebrafish retina, Müller glia (MG) can regenerate retinal neurons lost to injury or disease. Even though zebrafish MG... Delivery Method:
injection Organism or Cell Type:
zebrafish Citation Extract: Mitra S, Devi S, Lee M-S, Goldman D. Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211690119. doi: 10.1073/pnas.2211690119. Epub 2022 Dec 5. |