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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development

Authors:
Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C
Citation:
Science. 2022 May 27;376(6596):968-973. doi: 10.1126/science.abe9582. Epub 2022 May 5
Epub:
Not Epub
Abstract:
N6-methyladenosine (m6A) is the most abundant internal modification on mammalian messenger RNA. It is installed by a writer...
Link:
https://www.science.org/doi/10.1126/science.abe9582
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: mESC and Mel624
Citation Extract:
Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science. 2022 May 27;376(6596):968-973. doi: 10.1126/science.abe9582. Epub 2022 May 5.

Isolation and Characterization of Germline Stem Cells in Protogynous Hermaphroditic Monopterus albus

Authors:
Sun X, Tao B, Wang Y, Hu W, Sun Y
Citation:
Int J Mol Sci. 2022;23:5861. doi:10.3390/ijms23115861
Epub:
Not Epub
Abstract:
Germline stem cells (GSCs) are a group of unique adult stem cells in gonads that act as important transmitters for genetic...
Link:
https://www.mdpi.com/1422-0067/23/11/5861
Delivery Method:
microinjection
Organism or Cell Type:
Monopterus albus (rice field eel)
Citation Extract:
Sun X, Tao B, Wang Y, Hu W, Sun Y. Isolation and Characterization of Germline Stem Cells in Protogynous Hermaphroditic Monopterus albus. Int J Mol Sci. 2022;23:5861. doi:10.3390/ijms23115861.

Long-Term Functional Efficacy and Safety of Viltolarsen in Patients with Duchenne Muscular Dystrophy

Authors:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators, Hoffman EP
Citation:
J Neuromuscul Dis. 2022 May 24. doi: 10.3233/JND-220811. Online ahead of print
Epub:
Yes
Abstract:
Background: Duchenne muscular dystrophy (DMD) is a rare, genetic disease caused by mutations in the DMD gene resulting in an...
Link:
https://content.iospress.com/articles/journal-of-neuromuscular-diseases/jnd220811
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators, Hoffman EP. Long-Term Functional Efficacy and Safety of Viltolarsen in Patients with Duchenne Muscular Dystrophy. J Neuromuscul Dis. 2022 May 24. doi: 10.3233/JND-220811. Online ahead of print.

Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling

Authors:
Jacobs CT, Kejriwal A, Kocha KM, Jin KY, Huang P
Citation:
Dev Biol. 2022 May 24:S0012-1606(22)00098-7. doi: 10.1016/j.ydbio.2022.05.010. Online ahead of print
Epub:
Yes
Abstract:
During neural development, progenitor cells generate different types of neurons in specific time windows. Despite the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160622000987
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jacobs CT, Kejriwal A, Kocha KM, Jin KY, Huang P. Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling. Dev Biol. 2022 May 24:S0012-1606(22)00098-7. doi: 10.1016/j.ydbio.2022.05.010. Online ahead of print.

N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway

Authors:
Fu S, Tan R, Feng Y, Yu P, Mo Y, Xiao W, Wang S, Zhang J
Citation:
Ecotoxicol Environ Saf. 2022 May 24;239:113674. doi: 10.1016/j.ecoenv.2022.113674. Online ahead of print
Epub:
Not Epub
Abstract:
N-methyl-N-nitrosourea (MNU) is a prevalent environmental carcinogen, which leads to tumors in various organs in animal models...
Link:
https://www.sciencedirect.com/science/article/pii/S0147651322005140
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fu S, Tan R, Feng Y, Yu P, Mo Y, Xiao W, Wang S, Zhang J. N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway. Ecotoxicol Environ Saf. 2022 May 24;239:113674. doi: 10.1016/j.ecoenv.2022.113674. Online ahead of print.

Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development

Authors:
Xu W, Nelson-Maney NP, Bálint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM
Citation:
Int J Mol Sci. 2022 May 20;23(10):5712. doi: 10.3390/ijms23105712
Epub:
Not Epub
Abstract:
Numerous studies have focused on the molecular signaling pathways that govern the development and growth of lymphatics in the...
Link:
https://www.mdpi.com/1422-0067/23/10/5712
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu W, Nelson-Maney NP, Bálint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM. Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Int J Mol Sci. 2022 May 20;23(10):5712. doi: 10.3390/ijms23105712.

Regulators specifying cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues

Authors:
Kobayashi K, Tokuoka M, Sato H, Ariyoshi M, Kawahara S, Fujiwara S, Kishimoto T, Satou Y
Citation:
Development. 2022 Nov 15;149(22):dev201218. doi: 10.1242/dev.201218. Epub 2022 Nov 16. PMID: 36278804
Epub:
Not Epub
Abstract:
In animal development, most cell types stop dividing before terminal differentiation; thus, cell cycle control is tightly...
Link:
https://journals.biologists.com/dev/article/149/22/dev201218/282402/Regulators-specifying-cell-fate-activate-cell
Delivery Method:
microinjection
Organism or Cell Type:
Ciona savignyi (ascidian)
Citation Extract:
Kobayashi K, Tokuoka M, Sato H, Ariyoshi M, Kawahara S, Fujiwara S, Kishimoto T, Satou Y. Regulators specifying cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues. Development. 2022 Nov 15;149(22):dev201218. doi: 10.1242/dev.201218. Epub 2022 Nov 16. PMID: 36278804.

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Authors:
Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, Haward F, Adams IR, Caceres JF, Preyzner P, von Kriegsheim A, Dunlop MG, Din FV, Myant KB
Citation:
Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z
Epub:
Not Epub
Abstract:
Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are...
Link:
https://www.nature.com/articles/s41467-022-30489-z
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse intestine cells
Citation Extract:
Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, Haward F, Adams IR, Caceres JF, Preyzner P, von Kriegsheim A, Dunlop MG, Din FV, Myant KB. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z.

Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain

Authors:
Powell GT, Faro A, Zhao Y, Stickney H, Novellasdemunt L, Henriques P, Gestri G, Redhouse White E, Ren J, Lu W, Young RM, Hawkins TA, Cavodeassi F, Schwarz Q, Dreosti E, Raible DW, Li VSW, Wright GJ, Jones EY, Wilson SW
Citation:
Science. 2024 May 3;384(6695):573-579. doi: 10.1126/science.ade6970. Epub 2024 May 2. PMID: 38696577; PMCID: PMC7615972
Epub:
Not Epub
Abstract:
Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is...
Link:
https://www.science.org/doi/10.1126/science.ade6970
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Powell GT, Faro A, Zhao Y, Stickney H, Novellasdemunt L, Henriques P, Gestri G, Redhouse White E, Ren J, Lu W, Young RM, Hawkins TA, Cavodeassi F, Schwarz Q, Dreosti E, Raible DW, Li VSW, Wright GJ, Jones EY, Wilson SW. Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science. 2024 May 3;384(6695):573-579. doi: 10.1126/science.ade6970. Epub 2024 May 2. PMID: 38696577; PMCID: PMC7615972.

Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion

Authors:
Kwon V, Cai P, Dixon CT, Hamlin V, Spencer CG, Rojas AM, Hamilton M, Shiau CE
Citation:
Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z
Epub:
Not Epub
Abstract:
Inflammation is known to disrupt normal behavior, yet the underlying neuroimmune interactions remain elusive. Here, we...
Link:
https://www.nature.com/articles/s42003-022-03410-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kwon V, Cai P, Dixon CT, Hamlin V, Spencer CG, Rojas AM, Hamilton M, Shiau CE. Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion. Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z.

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