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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish Kryptolebias marmoratus

Authors:
Saud HA, O'Neill PA, Ono Y, Verbruggen B, Van Aerle R, Kim J, Lee JS, Ring BC, Kudoh T
Citation:
Development. 2021 Dec 15;148(24):dev199675. doi: 10.1242/dev.199675. Epub 2021 Dec 24
Epub:
Not Epub
Abstract:
Using the self-fertilizing mangrove killifish, we characterized two mutants, shorttail (stl) and balltail (btl). These mutants...
Link:
https://journals.biologists.com/dev/article/148/24/dev199675/273863/Molecular-mechanisms-of-embryonic-tail-development
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Saud HA, O'Neill PA, Ono Y, Verbruggen B, Van Aerle R, Kim J, Lee JS, Ring BC, Kudoh T. Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish Kryptolebias marmoratus. Development. 2021 Dec 15;148(24):dev199675. doi: 10.1242/dev.199675. Epub 2021 Dec 24.

Methylmercury-induced hair cell loss requires hydrogen peroxide production and leukocytes in zebrafish embryos

Authors:
Luo Z, Guo S, Ho NY, Takamiya M, Strähle U, Yang L
Citation:
Toxicol Lett. 2021 Dec 23:S0378-4274(21)00918-8. doi: 10.1016/j.toxlet.2021.12.012. Online ahead of print
Epub:
Yes
Abstract:
Hearing impairment and deafness is frequently observed as one of the neurological signs in patients with Minamata disease...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0378427421009188
Organism or Cell Type:
zebrafish
Citation Extract:
Luo Z, Guo S, Ho NY, Takamiya M, Strähle U, Yang L. Methylmercury-induced hair cell loss requires hydrogen peroxide production and leukocytes in zebrafish embryos. Toxicol Lett. 2021 Dec 23:S0378-4274(21)00918-8. doi: 10.1016/j.toxlet.2021.12.012. Online ahead of print.

Cyp11a2 is essential for oocyte development and spermatogonial stem cell differentiation in zebrafish

Authors:
Wang Y, Ye D, Zhang F, Zhang R, Zhu J, Wang H, He M, Sun Y
Citation:
Endocrinology. 2021;[epub] doi:10.1210/endocr/bqab258
Epub:
Yes
Abstract:
Cytochrome P45011A1, encoded by Cyp11a1, converts cholesterol to pregnenolone (P5), the first and rate-limiting step in...
Link:
https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/endocr/bqab258/6473198
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang Y, Ye D, Zhang F, Zhang R, Zhu J, Wang H, He M, Sun Y. Cyp11a2 is essential for oocyte development and spermatogonial stem cell differentiation in zebrafish. Endocrinology. 2021;[epub] doi:10.1210/endocr/bqab258.

Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs

Authors:
Wu X, Zhang H, Zhang B, Zhang Y, Wang Q, Shen W, Wu X, Li L, Xia W, Nakamura R, Liu B, Liu F, Takeda H, Meng A, Xie W
Citation:
Sci Adv. 2021;7(52):eabl3858 doi:10.1126/sciadv.abl3858
Epub:
Not Epub
Abstract:
Marked epigenetic reprogramming is essential to convert terminally differentiated gametes to totipotent embryos. It remains...
Link:
https://www.science.org/doi/10.1126/sciadv.abl3858
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu X, Zhang H, Zhang B, Zhang Y, Wang Q, Shen W, Wu X, Li L, Xia W, Nakamura R, Liu B, Liu F, Takeda H, Meng A, Xie W. Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Sci Adv. 2021;7(52):eabl3858 doi:10.1126/sciadv.abl3858.

Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis

Authors:
Munjal A, Hannezo A, Tsai TY-C, Mitchison TJ, Megason SG
Citation:
Cell. 2021;184(26):6313-25. doi:10.1016/j.cell.2021.11.025
Epub:
Not Epub
Abstract:
How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0092867421013738
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Munjal A, Hannezo A, Tsai TY-C, Mitchison TJ, Megason SG. Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Cell. 2021;184(26):6313-25. doi:10.1016/j.cell.2021.11.025.

A self-generated Toddler gradient guides mesodermal cell migration

Authors:
Stock J, Kazmar T, Schlumm F, Hannezo E, Pauli A
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.12.16.472981
Epub:
Not Epub
Abstract:
The sculpting of germ layers during gastrulation relies on coordinated migration of progenitor cells, yet the cues controlling...
Link:
https://www.biorxiv.org/content/10.1101/2021.12.16.472981v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Stock J, Kazmar T, Schlumm F, Hannezo E, Pauli A. A self-generated Toddler gradient guides mesodermal cell migration. bioRxiv. 2021;[preprint] doi:10.1101/2021.12.16.472981 .

Differential regulation of SHH signaling and the developmental control of species-specific jaw size through neural crest-mediated Gas1 expression

Authors:
Vavrusová Z, Chu DB, Nguyen A, Fish JL, Schneider RA
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.12.17.473230
Epub:
Not Epub
Abstract:
Developmental control of jaw size is crucial to prevent disease and facilitate evolution. We have shown that species-specific...
Link:
https://www.biorxiv.org/content/10.1101/2021.12.17.473230v1
Delivery Method:
in ovo injection Vivo-Morpholino
Organism or Cell Type:
Coturnix coturnix japonica (Japanese quail)
Citation Extract:
Vavrusová Z, Chu DB, Nguyen A, Fish JL, Schneider RA. Differential regulation of SHH signaling and the developmental control of species-specific jaw size through neural crest-mediated Gas1 expression. bioRxiv. 2021;[preprint] doi:10.1101/2021.12.17.473230.

l-selenomethionine induces zebrafish embryo cardiovascular defects via down-regulating expression of lrp2b

Authors:
Zhao G, Zhu Y, Hu J, Gao M, Hong Y
Citation:
Chemosphere. 2021 Dec 18:133351. doi: 10.1016/j.chemosphere.2021.133351. Online ahead of print
Epub:
Yes
Abstract:
Selenium plays crucial roles in maintaining the growth and development of vertebrates including humans. However, excessive...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S004565352103825X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao G, Zhu Y, Hu J, Gao M, Hong Y. l-selenomethionine induces zebrafish embryo cardiovascular defects via down-regulating expression of lrp2b. Chemosphere. 2021 Dec 18:133351. doi: 10.1016/j.chemosphere.2021.133351. Online ahead of print.

Knockdown and Knockout of Tissue Factor Pathway Inhibitor in Zebrafish

Authors:
Raman R, Fallatah W, Al Qaryoute A, Ryon M, Jagadeeswaran P
Citation:
Thromb Haemost. 2021 Dec 16. doi: 10.1055/a-1723-4075. Online ahead of print
Epub:
Yes
Abstract:
Tissue Factor Pathway Inhibitor (TFPI) is an anticoagulant that inhibits factor VIIa and Xa in the blood coagulation pathways....
Link:
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1723-4075
Delivery Method:
Vivo-Morpholino piggyback hybrid
Organism or Cell Type:
zebrafish
Citation Extract:
Raman R, Fallatah W, Al Qaryoute A, Ryon M, Jagadeeswaran P. Knockdown and Knockout of Tissue Factor Pathway Inhibitor in Zebrafish. Thromb Haemost. 2021 Dec 16. doi: 10.1055/a-1723-4075. Online ahead of print.

A novel role of PRL in regulating epithelial cell density by inducing apoptosis at confluence

Authors:
Lohani S, Funato Y, Akieda Y, Mizutani K, Takai Y, Ishitani T, Miki H
Citation:
J Cell Sci. 2021 Dec 21:jcs.258550. doi: 10.1242/jcs.258550. Online ahead of print
Epub:
Yes
Abstract:
Maintaining proper epithelial cell density is essential for the survival of multicellular organisms. While regulation of cell...
Link:
https://journals.biologists.com/jcs/article-abstract/doi/10.1242/jcs.258550/273809/A-novel-role-of-PRL-in-regulating-epithelial-cell
Organism or Cell Type:
zebrafish
Citation Extract:
Lohani S, Funato Y, Akieda Y, Mizutani K, Takai Y, Ishitani T, Miki H. A novel role of PRL in regulating epithelial cell density by inducing apoptosis at confluence. J Cell Sci. 2021 Dec 21:jcs.258550. doi: 10.1242/jcs.258550. Online ahead of print.

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