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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
miR-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development
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Citation:
bioRxiv. 2021;[preprint]. doi:10.1101/2021.12.10.471989 Epub:
Not Epub Abstract:
MicroRNAs (miRNAs) regulate gene expression by destabilizing target mRNA and/or inhibiting translation in animal cells. The... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin) Citation Extract: Konrad KD, Song JL. miR-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development. bioRxiv. 2021;[preprint]. doi:10.1101/2021.12.10.471989. |
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
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Citation:
Science. 2021;374(6573):eabk0410. doi:10.1126/science.abk0410 Epub:
Not Epub Abstract:
Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo W-T, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Science. 2021;374(6573):eabk0410. doi:10.1126/science.abk0410. |
KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion
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Citation:
Nat Commun. 2021;12:7180. doi:10.1038/s41467-021-27513-z Epub:
Not Epub Abstract:
Metastasis is the main cause of carcinoma-related death, yet we know little about how it initiates due to our inability to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Fadul J, Zulueta-Coarasa T, Slattum GM, Redd NM, Jin MF, Redd MJ, Daetwyler S, Hedeen D, Huisken J, Rosenblatt J. KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion. Nat Commun. 2021;12:7180. doi:10.1038/s41467-021-27513-z. |
PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans
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Citation:
Nat Med. 2021:[Epub ahead of print]. doi:10.1038/s41591-021-01572-7 Epub:
Yes Abstract:
Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset disease that often causes death or severe... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nat Med. 2021:[Epub ahead of print]. doi:10.1038/s41591-021-01572-7. |
Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy
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Citation:
Nat Commun. 2021;12(1):7151. doi:10.1038/s41467-021-27461-8 Epub:
Not Epub Abstract:
The heterozygous Phospholamban p.Arg14del mutation is found in patients with dilated or arrhythmogenic cardiomyopathy. This... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Boukens BJD, de Jonge B, Onderwater YL, van Alebeek E, Chocron S, Polidoro Pontalti C, Weuring WJ, Vos MA, de Boer TP, van Veen TAB, Bakkers J. Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy. Nat Commun. 2021;12(1):7151. doi:10.1038/s41467-021-27461-8. |
Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.12.07.471519 Epub:
Not Epub Abstract:
Immigration of mesenchymal cells into the growing fin and limb buds drives distal outgrowth, with subsequent tensile forces... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Mahabaleshwar H, Asharani PV, Loo TYJ, Koh SY, Pitman MR, Kwok S, Ma J, Hu B, Lin F, Lok XL, Pitson SM, Saunders TE, Carney TJ. Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology. bioRxiv. 2021;[preprint] doi:10.1101/2021.12.07.471519. |
Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice
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Citation:
Nat Commun. 2021;12(1):7101. doi:10.1038/s41467-021-26714-w Epub:
Not Epub Abstract:
Genome editing therapy for Duchenne muscular dystrophy (DMD) holds great promise, however, one major obstacle is delivery of... Delivery Method:
i.m. injection Organism or Cell Type:
mice Citation Extract: Kenjo E, Hozumi H, Makita Y, Iwabuchi KA, Fujimoto N, Matsumoto S, Kimura M, Amano Y, Ifuku M, Naoe Y, Inukai N, Hotta A. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021;12(1):7101. doi:10.1038/s41467-021-26714-w. |
Collective durotaxis along a self-generated stiffness gradient in vivo
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Citation:
Nature. 2021;[Epub ahead of print]. doi:10.1038/s41586-021-04210-x Epub:
Not Epub Abstract:
Collective cell migration underlies morphogenesis, wound healing and cancer invasion. Most directed migration in vivo has been... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Shellard A, Mayor R. Collective durotaxis along a self-generated stiffness gradient in vivo. Nature. 2021;[Epub ahead of print]. doi:10.1038/s41586-021-04210-x. |
Mechanisms underlying microglial colonization of developing neural retina in zebrafish
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Citation:
eLife. 2021;10:e70550. doi:10.7554/eLife.70550 Epub:
Not Epub Abstract:
Microglia are brain-resident macrophages that function as the first line of defense in brain. Embryonic microglial precursors... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ranawat N, Masai I. Mechanisms underlying microglial colonization of developing neural retina in zebrafish. eLife. 2021;10:e70550. doi:10.7554/eLife.70550. |
Restoration of Normal NF1 Function with Antisense Morpholino Treatment of Recurrent Pathogenic Patient-Specific Variant c.1466A>G; p.Y489C
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Citation:
J Pers Med 2021;11(12):1320. doi:10.3390/jpm11121320 Epub:
Not Epub Abstract:
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with almost 3000 different disease-causing variants... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: human PGP1 iPSC Citation Extract: Awad EK, Moore M, Liu H, Ciszewski L, Lambert L, Korf BR, Popplewell L, Kesterson RA, Wallis D. Restoration of Normal NF1 Function with Antisense Morpholino Treatment of Recurrent Pathogenic Patient-Specific Variant c.1466A>G; p.Y489C. J Pers Med 2021;11(12):1320. doi:10.3390/jpm11121320. |