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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Novel pre-clinical model for CDKL5 Deficiency Disorder

Authors:
Serrano RJ, Lee C, Douek AM, Kaslin J, Bryson-Richardson RJ, Sztal TE
Citation:
Dis Model Mech 2021;[Epub] doi:10.1242/dmm.049094
Epub:
Yes
Abstract:
Cyclin-Dependent Kinase-Like-5 (CDKL5) Deficiency Disorder (CDD) is a severe X-linked neurodegenerative disease characterized...
Link:
https://journals.biologists.com/dmm/article/doi/10.1242/dmm.049094/273746/Novel-pre-clinical-model-for-CDKL5-Deficiency
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Serrano RJ, Lee C, Douek AM, Kaslin J, Bryson-Richardson RJ, Sztal TE. Novel pre-clinical model for CDKL5 Deficiency Disorder. Dis Model Mech 2021;[Epub] doi:10.1242/dmm.049094.

Targeted search for scaling genes reveals matrix metalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos

Authors:
Orlov EE, Nesterenko AM, Korotkova DD, Parshina EA, Martynova NY, Zaraisky AG
Citation:
Dev Cell. 2021;[Epub] doi:10.1016/j.devcel.2021.11.021
Epub:
Yes
Abstract:
How embryos scale patterning according to size is still not fully understood. Through in silico screening and analysis of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S153458072100945X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Orlov EE, Nesterenko AM, Korotkova DD, Parshina EA, Martynova NY, Zaraisky AG. Targeted search for scaling genes reveals matrix metalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos. Dev Cell. 2021;[Epub] doi:10.1016/j.devcel.2021.11.021.

Who is the best surrogate for germ stem cell transplantation in fish?

Authors:
Franěk R, Cheng Y, Fučíková M, Kašpar V, Xie X, Shah MA, Linhart O, Šauman I, Pšenička
Citation:
Aquaculture. 2022;549:737759. [Epub] doi:10.1016/j.aquaculture.2021.737759
Epub:
Yes
Abstract:
Surrogate broodstock technology in fishes has potential for aquaculture as well as endangered species conservation and...
Link:
https://www.sciencedirect.com/science/article/pii/S0044848621014228
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Franěk R, Cheng Y, Fučíková M, Kašpar V, Xie X, Shah MA, Linhart O, Šauman I, Pšenička. Who is the best surrogate for germ stem cell transplantation in fish?. Aquaculture. 2022;549:737759. [Epub] doi:10.1016/j.aquaculture.2021.737759.

TNNT1 myopathy with novel compound heterozygous mutations

Authors:
Lee S, Eum J, Park S, Ki S, Hwang BJ, Kee Y, Chae JH
Citation:
Neuromuscul Disord. 2021;[Epub ahead of print] doi:10.1016/j.nmd.2021.12.003
Epub:
Not Epub
Abstract:
Nemaline myopathies are clinically and genetically heterogeneous disorders caused by several different genes. One of them is...
Link:
https://www.nmd-journal.com/article/S0960-8966(21)00736-7/fulltext#%20
Organism or Cell Type:
zebrafish
Citation Extract:
Lee S, Eum J, Park S, Ki S, Hwang BJ, Kee Y, Chae JH. TNNT1 myopathy with novel compound heterozygous mutations. Neuromuscul Disord. 2021;[Epub ahead of print] doi:10.1016/j.nmd.2021.12.003.

Pharmacology and toxicology of eteplirsen and SRP-5051 for DMD exon 51 skipping: an update

Authors:
Sheikh O, Yokota T
Citation:
Arch Toxicol. 2021 Nov 19. doi: 10.1007/s00204-021-03184-z. Online ahead of print
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) afflicts 1 in 5000 newborn males, leading to progressive muscle weakening and the loss of...
Link:
https://link.springer.com/article/10.1007%2Fs00204-021-03184-z
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Sheikh O, Yokota T. Pharmacology and toxicology of eteplirsen and SRP-5051 for DMD exon 51 skipping: an update. Arch Toxicol. 2021 Nov 19. doi: 10.1007/s00204-021-03184-z. Online ahead of print.

Pharmacological Profile of Viltolarsen for the Treatment of Duchenne Muscular Dystrophy: A Japanese Experience

Authors:
Roshmi RR, Yokota T
Citation:
Clin. Pharmacol. 2021;13:235-42. doi:10.2147/CPAA.S288842
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a fatal, X-linked recessive disorder characterized by progressive muscle loss and...
Link:
https://www.dovepress.com/pharmacological-profile-of-viltolarsen-for-the-treatment-of-duchenne-m-peer-reviewed-fulltext-article-CPAA
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Roshmi RR, Yokota T. Pharmacological Profile of Viltolarsen for the Treatment of Duchenne Muscular Dystrophy: A Japanese Experience. Clin. Pharmacol. 2021;13:235-42. doi:10.2147/CPAA.S288842.

Casimersen for Duchenne muscular dystrophy

Authors:
Wilton-Clark H, Yokota T
Citation:
Drugs Today (Barc). 2021 Dec;57(12):707-717. doi: 10.1358/dot.2021.57.12.3352740
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a genetic disorder affecting 1 in 5,000 males which causes progressive muscle...
Link:
https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=4&p_RefId=3352740&p_IsPs=N
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Wilton-Clark H, Yokota T. Casimersen for Duchenne muscular dystrophy. Drugs Today (Barc). 2021 Dec;57(12):707-717. doi: 10.1358/dot.2021.57.12.3352740.

Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice

Authors:
Wang X, Wang L, Dou J, Yu T, Cao P, Fan N, Borjigin U, Nashun B
Citation:
Epigenetics Chromatin. 2021 Dec 14;14(1):55. doi: 10.1186/s13072-021-00430-7
Epub:
Not Epub
Abstract:
Background: Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. Two...
Link:
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-021-00430-7
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Wang X, Wang L, Dou J, Yu T, Cao P, Fan N, Borjigin U, Nashun B. Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice. Epigenetics Chromatin. 2021 Dec 14;14(1):55. doi: 10.1186/s13072-021-00430-7.

Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates

Authors:
Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B
Citation:
Nat Genet. 2021 Dec 13. doi: 10.1038/s41588-021-00970-4. Online ahead of print
Epub:
Yes
Abstract:
The vertebrate left-right axis is specified during embryogenesis by a transient organ: the left-right organizer (LRO). Species...
Link:
https://www.nature.com/articles/s41588-021-00970-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B. Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nat Genet. 2021 Dec 13. doi: 10.1038/s41588-021-00970-4. Online ahead of print.

FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish

Authors:
Xu G, Huang Z, Sheng J, Gao X, Xin W, Garcia JQ, Wei G, Liu D, Gong J
Citation:
Exp Neurol. 2021 Dec 8:113944. doi: 10.1016/j.expneurol.2021.113944. Online ahead of print
Epub:
Yes
Abstract:
Fibroblast growth factor binding protein 3 (Fgfbp3) have been known to be crucial for the process of neural proliferation,...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0014488621003526
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu G, Huang Z, Sheng J, Gao X, Xin W, Garcia JQ, Wei G, Liu D, Gong J. FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish. Exp Neurol. 2021 Dec 8:113944. doi: 10.1016/j.expneurol.2021.113944. Online ahead of print.

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