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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

Authors:
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK
Citation:
Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2
Epub:
Yes
Abstract:
The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and...
Link:
https://www.nature.com/articles/s41564-021-00964-2
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK. Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy. Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2.

Tightly linked morpholino-nucleoside chimeras: new, compact cationic oligonucleotide analogues

Authors:
Debreczeni N, Bege M, Herczeg M, Bereczki I, Batta G, Herczegh P, Borbás A
Citation:
Org Biomol Chem. 2021;[Epub] doi:10.1039/D1OB01174J
Epub:
Yes
Abstract:
The polyanionic phosphodiester backbone of nucleic acids contributes to high nuclease sensitivity and low cellular uptake and...
Link:
https://pubs.rsc.org/en/Content/ArticleLanding/2021/OB/D1OB01174J
Citation Extract:
Debreczeni N, Bege M, Herczeg M, Bereczki I, Batta G, Herczegh P, Borbás A. Tightly linked morpholino-nucleoside chimeras: new, compact cationic oligonucleotide analogues. Org Biomol Chem. 2021;[Epub] doi:10.1039/D1OB01174J.

Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling

Authors:
Vicente M, Salgado-Almario J, Collins MM, Martínez-Sielva A, Minoshima M, Kikuchi K, Domingo B, Llopis J
Citation:
Biomedicines. 2021;9(10):1294. doi:10.3390/biomedicines9101294
Epub:
Not Epub
Abstract:
Zebrafish embryos and larvae have emerged as an excellent model in cardiovascular research and are amenable to live imaging...
Link:
https://www.mdpi.com/2227-9059/9/10/1294
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vicente M, Salgado-Almario J, Collins MM, Martínez-Sielva A, Minoshima M, Kikuchi K, Domingo B, Llopis J. Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling. Biomedicines. 2021;9(10):1294. doi:10.3390/biomedicines9101294.

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

Authors:
Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S
Citation:
Elife. 2021 Sep 22;10:e69795. doi: 10.7554/eLife.69795
Epub:
Not Epub
Abstract:
Parkinson's disease (PD) is a common neurodegenerative disorder without effective disease-modifying therapeutics. Here, we...
Link:
https://elifesciences.org/articles/69795
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 2021 Sep 22;10:e69795. doi: 10.7554/eLife.69795.

Role of Ribosomal RNA Released from Red Cells in Blood Coagulation in Zebrafish and Humans

Authors:
Alharbi A, Iyer N, AlQaryoute A, Raman R, Burks D, Azad R, Jagadeeswaran P
Citation:
Blood Adv. 2021 Nov 23;5(22):4634-4647. doi: 10.1182/bloodadvances.2020003325.
Epub:
Not Epub
Abstract:
Hemolytic disorders are characterized by hemolysis and are prone to thrombosis. Previously, it has been shown that the RNA...
Link:
https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2020003325/476980/Role-of-Ribosomal-RNA-Released-from-Red-Cells-in
Delivery Method:
zebrafish injection (piggyback Vivo-Morpholino + DNA)
Organism or Cell Type:
zebrafish
Citation Extract:
Alharbi A, Iyer N, AlQaryoute A, Raman R, Burks D, Azad R, Jagadeeswaran P. Role of Ribosomal RNA Released from Red Cells in Blood Coagulation in Zebrafish and Humans. Blood Adv. 2021 Nov 23;5(22):4634-4647. doi: 10.1182/bloodadvances.2020003325. .

Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease

Authors:
Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch K, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS
Citation:
Proc Nat Acad Sci USA. 2021;118(39):e2106770118. doi:10.1073/pnas.2106770118
Epub:
Not Epub
Abstract:
Skeletal ciliopathies (e.g., Jeune syndrome, short rib polydactyly syndrome, and Sensenbrenner syndrome) are frequently...
Link:
https://www.pnas.org/content/118/39/e2106770118
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch K, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS. Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease. Proc Nat Acad Sci USA. 2021;118(39):e2106770118. doi:10.1073/pnas.2106770118.

HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production

Authors:
Wang J, Chen Y, Zeng Z, Feng R, Wang Q, Zhang Q, Sun K, Chen AF, Lu Y, Yu Y
Citation:
Exp Cell Res. 2021 Sep 18:112831. doi:10.1016/j.yexcr.2021.112831.
Epub:
Not Epub
Abstract:
Angiogenesis is the process by which new blood vessels form from preexisting vessels and regulates the processes of embryonic...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0014482721003852
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang J, Chen Y, Zeng Z, Feng R, Wang Q, Zhang Q, Sun K, Chen AF, Lu Y, Yu Y. HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Exp Cell Res. 2021 Sep 18:112831. doi:10.1016/j.yexcr.2021.112831..

Cell-cell contact landscapes in Xenopus gastrula tissues

Authors:
Barua D, Nagel M, Winklbauer R
Citation:
Proc Nat Acad Sci USA. 2021;118(39):e2107953118 [Epub] doi:10.1073/pnas.2107953118
Epub:
Yes
Abstract:
Molecular and structural facets of cell-cell adhesion have been extensively studied in monolayered epithelia. Here, we perform...
Link:
https://www.pnas.org/content/118/39/e2107953118
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Barua D, Nagel M, Winklbauer R. Cell-cell contact landscapes in Xenopus gastrula tissues. Proc Nat Acad Sci USA. 2021;118(39):e2107953118 [Epub] doi:10.1073/pnas.2107953118.

Notch-mediated re-specification of neuronal identity during central nervous system development

Authors:
Engerer P, Petridou E, Williams PR, Suzuki SC, Yoshimatsu T, Portugues R, Misgeld T, Godinho L
Citation:
Current Biology. 2021;[Epub] doi: 10.1016/j.cub.2021.08.049
Epub:
Not Epub
Abstract:
Neuronal identity has long been thought of as immutable, so that once a cell acquires a specific fate, it is maintained for...
Link:
https://www.cell.com/current-biology/fulltext/S0960-9822(21)01185-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Engerer P, Petridou E, Williams PR, Suzuki SC, Yoshimatsu T, Portugues R, Misgeld T, Godinho L. Notch-mediated re-specification of neuronal identity during central nervous system development. Current Biology. 2021;[Epub] doi: 10.1016/j.cub.2021.08.049.

A new strategy to increase RNA Editing at the Q/R Site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2

Authors:
Chaytow H, Hassan IS, Akbar S, Popplewell L, Dickson G, Chen PE
Citation:
J Neurosci Methods. 2021;[Epub] doi:10.1016/j.jneumeth.2021.109357
Epub:
Not Epub
Abstract:
Background: The GluA2 subunit of AMPA receptors (AMPARs) undergoes RNA editing at a specific base mediated by the enzyme ADAR2...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0165027021002922
Organism or Cell Type:
cell culture
Citation Extract:
Chaytow H, Hassan IS, Akbar S, Popplewell L, Dickson G, Chen PE. A new strategy to increase RNA Editing at the Q/R Site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2. J Neurosci Methods. 2021;[Epub] doi:10.1016/j.jneumeth.2021.109357.

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