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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 Disease
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Citation:
Biomedicines. 2021;9(8):1018. doi:10.3390/biomedicines9081018 Epub:
Not Epub Abstract:
Therapeutic modalities designed specifically to inhibit COVID-19 infection and replication would limit progressive COVID-19-... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: Vero E6 Citation Extract: Hildreth JEK, Moulton JD, Alcendor DJ. Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 Disease. Biomedicines. 2021;9(8):1018. doi:10.3390/biomedicines9081018. |
Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability
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Citation:
PLoS ONE. 2021;16(8):e0256181. doi:journal.pone.0256181 Epub:
Not Epub Abstract:
Identifying causative variants in cis-regulatory elements (CRE) in neurodevelopmental disorders has proven challenging. We have... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bengani H, Grozeva D, Moyon L, Bhatia S, Louros SR, Hope J, Jackson A, Prendergast JG, Owen LJ, Naville M, Rainger J, Grimes G, Halachev M, Murphy, Spasic-Boskovic O, van Heyningen V, Kind P, Abbott CM, Osterweil E, Raymond FL, Crollius HR, FitzPatrick DR. Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability. PLoS ONE. 2021;16(8):e0256181. doi:journal.pone.0256181. |
Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body
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Citation:
Dev Bio. 2021;[Epub} doi:10.1016/j.ydbio.2021.08.002 Epub:
Not Epub Abstract:
The neural crest (NC) is a transient multipotent cell population that migrates extensively to produce a remarkable array of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rocha M, Kushkowski E, Schnirman R, Booth C, Singh N, Beadell A, Prince VE. Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body. Dev Bio. 2021;[Epub} doi:10.1016/j.ydbio.2021.08.002. |
Open reading frame correction using antisense oligonucleotides for the treatment of cystic fibrosis caused by CFTR-W1282X
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.11.455834 Epub:
Not Epub Abstract:
CFTR gene mutations that result in the introduction of premature termination codons (PTCs) are common in cystic fibrosis (CF).... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: CFTR-W1282X bronchial epithelial line, primary CFTR-W1282X epithelial cells Citation Extract: Michaels WE, Pena-Rasgado C, Kotaria R, Bridges RJ, Hastings ML. Open reading frame correction using antisense oligonucleotides for the treatment of cystic fibrosis caused by CFTR-W1282X. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.11.455834. |
Dietary Nucleotides Alleviate Hepatic Lipid Deposition via Exogenous AMP-Mediated AMPK Activation in Zebrafish
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Citation:
J Nutr. 2021;nxab232 {Epub] doi:doi.org/10.1093/jn/nxab232 Epub:
Yes Abstract:
Background: Dietary nucleotides (NTs) have been reported to affect hepatic function and composition. However, the effects on... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
zebrafish Citation Extract: Ran C, Xie M, Li J, Xie Y, Ding Q, Li Y, Zhou W, Yang Y, Zhang Z, Olsen RE, Zhou Z. Dietary Nucleotides Alleviate Hepatic Lipid Deposition via Exogenous AMP-Mediated AMPK Activation in Zebrafish. J Nutr. 2021;nxab232 {Epub] doi:doi.org/10.1093/jn/nxab232. |
DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.23.453490 Epub:
Not Epub Abstract:
In a previous study, it was reported that Yap1 and Wwtr1 in zebrafish regulates the morphogenesis of the posterior body and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lai JKH, Toh PJY, Cognart HA, Chouhan G, Saunders TE. DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.23.453490. |
Zic1 advances epaxial myotome morphogenesis to cover the neural tube via Wnt11r
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Citation:
bioRxiv. 20219;[preprint] doi:/10.1101/2021.07.12.452069 Epub:
Not Epub Abstract:
The dorsal axial muscles, or epaxial muscles, are a fundamental structure covering the spinal cord and vertebrae, as well as... Delivery Method:
microinjection Organism or Cell Type:
Oryzias latipes (medaka) Citation Extract: Heilig AK, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, Takeda H, Kawanishi T. Zic1 advances epaxial myotome morphogenesis to cover the neural tube via Wnt11r. bioRxiv. 20219;[preprint] doi:/10.1101/2021.07.12.452069. |
The E3 Ubiquitin Ligase Mindbomb1 controls zebrafish Planar Cell Polarity
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.05.451064 Epub:
Not Epub Abstract:
Vertebrate Delta/Notch signaling involves multiple ligands, receptors and transcription factors. Delta endocytosis – a critical... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Saraswathy VM, Sharma P, Kurup AJ, Polès S, Poulain M, Fürthauer M. The E3 Ubiquitin Ligase Mindbomb1 controls zebrafish Planar Cell Polarity. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.05.451064 . |
Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy
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Citation:
Front Cell Dev Biol. 2021;9:639904. doi:10.3389/fcell.2021.639904 Epub:
Not Epub Abstract:
Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disease affecting lower motor neurons that is caused by a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Koh A, Sarusie MV, Ohmer J, Fischer U, Winkler C and Wohland T. Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy. Front Cell Dev Biol. 2021;9:639904. doi:10.3389/fcell.2021.639904. |
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
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Citation:
Nat Comm. 2021;12(1):4872. doi:10.1038/s41467-021-24998-6 Epub:
Not Epub Abstract:
The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely... Delivery Method:
Endo-Porter, microinjection Organism or Cell Type:
cell culture: HUVEC/TERT2, zebrafish Citation Extract: Pradella D, Deflorian G, Pezzotta A, Di Matteo A, Belloni E, Campolungo D, Paradisi A, Bugatti M, Vermi W, Campioni M, Chiapparino A, Scietti L, Forneris F, Giampietro C, Volf N, Rehman M, Zacchigna S, Paronetto MP, Pistocchi A, Eichmann A, Mehlen P, Ghigna C. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis. Nat Comm. 2021;12(1):4872. doi:10.1038/s41467-021-24998-6. |