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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Dominant rhabdomyolysis linked to a recurrent ATP2A2 variant reducing SERCA2 function in muscle

Authors:
Malaichamy S, Idoux R, Polavarapu K, Šikić K, Holla E, Thompson R, Spendiff S, Schänzer A, Kusters B, Freeman E, Hentschel A, O'Neil D, Carmona-Martinez R, Dobelmann V, Tucht C, Schouten M, Ruck T, Schara-Schmidt U, Kamsteeg EJ, Ramadža DP, Jakovčević A, Zigman T, Čavka M, Karcagi V, Herczegfalvi A, Laurie S, Matalonga L, Beltran S, Horvath R, Voermans N, Roos A, Barić I, Lochmüller H
Citation:
Brain. 2025 Feb 19:awaf067. doi: 10.1093/brain/awaf067. Epub ahead of print. PMID: 39970126
Epub:
Not Epub
Abstract:
Rhabdomyolysis is an acute failure of cellular homeostasis resulting in muscle breakdown, triggered by trauma, infection, drugs...
Link:
https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awaf067/8024349
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Malaichamy S, Idoux R, Polavarapu K, Šikić K, Holla E, Thompson R, Spendiff S, Schänzer A, Kusters B, Freeman E, Hentschel A, O'Neil D, Carmona-Martinez R, Dobelmann V, Tucht C, Schouten M, Ruck T, Schara-Schmidt U, Kamsteeg EJ, Ramadža DP, Jakovčević A, Zigman T, Čavka M, Karcagi V, Herczegfalvi A, Laurie S, Matalonga L, Beltran S, Horvath R, Voermans N, Roos A, Barić I, Lochmüller H. Dominant rhabdomyolysis linked to a recurrent ATP2A2 variant reducing SERCA2 function in muscle. Brain. 2025 Feb 19:awaf067. doi: 10.1093/brain/awaf067. Epub ahead of print. PMID: 39970126.

De novo and inherited variants in DDX39B cause a novel neurodevelopmental syndrome

Authors:
Booth KTA, Jangam SV, Chui MMC, Treat K, Graziani L, Soldano A, Ruan Y, Wan-Hei Hui J, White K, Christensen CK, Lynnes T, Yamamoto S, Kanca O, Tsang MHY, Lynch SA, Mullegama SV, Batista J, Iancu D, Joss SK, Wong SYY, Mak CCY, Kwong AKY, Bellen HJ, Conboy E, Sanges R, Leung AY, Wangler MF, Chung BHY, Vetrini F
Citation:
Brain. 2025 Feb 7:awaf035. doi: 10.1093/brain/awaf035. Epub ahead of print. PMID: 39918047
Epub:
Not Epub
Abstract:
DDX39B is a conserved member of the DEAD-box family of ATP-dependent RNA helicases, critical in mRNA metabolism across...
Link:
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf035/8004980?login=false
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Booth KTA, Jangam SV, Chui MMC, Treat K, Graziani L, Soldano A, Ruan Y, Wan-Hei Hui J, White K, Christensen CK, Lynnes T, Yamamoto S, Kanca O, Tsang MHY, Lynch SA, Mullegama SV, Batista J, Iancu D, Joss SK, Wong SYY, Mak CCY, Kwong AKY, Bellen HJ, Conboy E, Sanges R, Leung AY, Wangler MF, Chung BHY, Vetrini F. De novo and inherited variants in DDX39B cause a novel neurodevelopmental syndrome. Brain. 2025 Feb 7:awaf035. doi: 10.1093/brain/awaf035. Epub ahead of print. PMID: 39918047.

Morpholino oligomer delivery via bath immersion for use in reverse genetic studies on the early development of eastern oysters (Crassostrea virginica)

Authors:
Xu L, Small JM, Hood SM, Zhao M, Plough LV, Wong T-T
Citation:
Aquaculture. Available online 5 February 2025, 742261
Epub:
Not Epub
Abstract:
The eastern oyster genome and expanding omics data have provided valuable insights into this species. However, the limited...
Link:
https://www.sciencedirect.com/science/article/pii/S0044848625001474
Delivery Method:
Vivo-Morpholino, peptide-linked, bathing
Organism or Cell Type:
Crassostrea virginica (eastern oyster)
Citation Extract:
Xu L, Small JM, Hood SM, Zhao M, Plough LV, Wong T-T. Morpholino oligomer delivery via bath immersion for use in reverse genetic studies on the early development of eastern oysters (Crassostrea virginica). Aquaculture. Available online 5 February 2025, 742261.

Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427

Authors:
Kostiuk V, Kabir R, Levangie K, Empke S, Morgan K, Owens NDL, Lusk CP, Khokha MK
Citation:
Development. 2025 Jan 15;152(2):dev202865. doi: 10.1242/dev.202865. Epub 2025 Feb 4. PMID: 39791357
Epub:
Not Epub
Abstract:
Emerging evidence suggests that the nuclear pore complex can have unique compositions and distinct nucleoporin functions in...
Link:
https://journals.biologists.com/dev/article/152/2/dev202865/365498/Nup107-contributes-to-the-maternal-to-zygotic
Delivery Method:
microinjection
Organism or Cell Type:
X. tropicalis
Citation Extract:
Kostiuk V, Kabir R, Levangie K, Empke S, Morgan K, Owens NDL, Lusk CP, Khokha MK. Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427. Development. 2025 Jan 15;152(2):dev202865. doi: 10.1242/dev.202865. Epub 2025 Feb 4. PMID: 39791357.

ROS regulates circadian rhythms by modulating Ezh2 interactions with clock proteins

Authors:
Zhang HY, Li KY, Wang YL, Wei CJ, Gao YX, Ren-Zhou, Zhong YB, Yin ZJ, Ren DL
Citation:
Redox Biol. 2025 Apr;81:103526. doi: 10.1016/j.redox.2025.103526. Epub 2025 Feb 3. PMID: 39952198; PMCID: PMC11875201
Epub:
Not Epub
Abstract:
Redox imbalance induced by the accumulation of reactive oxygen species (ROS) accelerates age-related processes, often...
Link:
https://www.sciencedirect.com/science/article/pii/S2213231725000394
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang HY, Li KY, Wang YL, Wei CJ, Gao YX, Ren-Zhou, Zhong YB, Yin ZJ, Ren DL. ROS regulates circadian rhythms by modulating Ezh2 interactions with clock proteins. Redox Biol. 2025 Apr;81:103526. doi: 10.1016/j.redox.2025.103526. Epub 2025 Feb 3. PMID: 39952198; PMCID: PMC11875201.

Solid Phase Synthesis of Casimersen and Its 3ʹ-end Modification for Therapeutic Benefits

Authors:
Sinha S, Das A, Pratihar S, Nath Sharma S, Kundu J
Citation:
ChemRxiv [preprint]. 2025; doi:10.26434/chemrxiv-2025-mf99n
Epub:
Not Epub
Abstract:
Phosphorodiamidate Morpholino Oligonucleotides (PMO) have been well established in the treatment of muscular dystrophies with...
Link:
https://chemrxiv.org/engage/chemrxiv/article-details/679a1eff6dde43c908d62731
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Sinha S, Das A, Pratihar S, Nath Sharma S, Kundu J. Solid Phase Synthesis of Casimersen and Its 3ʹ-end Modification for Therapeutic Benefits. ChemRxiv [preprint]. 2025; doi:10.26434/chemrxiv-2025-mf99n.

Yellow catfish (Pelteobagrus fulvidraco) lacking of germ cells exhibited gonadal sexual dimorphism

Authors:
Ye H, Hou Y, Huang L, Yue H, Qu Z, Ruan R, Li C
Citation:
Aquaculture. Online 28 January 2025
Epub:
Not Epub
Abstract:
Yellow catfish (Pelteobagrus fulvidraco) is a valuable freshwater aquaculture species in China, characterized by an XX/XY sex...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0044848625001139
Delivery Method:
microinjection
Organism or Cell Type:
catfish
Citation Extract:
Ye H, Hou Y, Huang L, Yue H, Qu Z, Ruan R, Li C. Yellow catfish (Pelteobagrus fulvidraco) lacking of germ cells exhibited gonadal sexual dimorphism. Aquaculture. Online 28 January 2025.

Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis

Authors:
Li S, Li H, Bennewitz K, Poschet G, Buettner M, Hausser I, Szendroedi J, Nawroth PP, Kroll J
Citation:
Metabolism. 2025 Jan 30:156149. doi: 10.1016/j.metabol.2025.156149. Epub ahead of print. PMID: 39892865
Epub:
Not Epub
Abstract:
Background & aims: Any energy consumption results in the generation of highly reactive dicarbonyls and the need to prevent...
Link:
https://www.metabolismjournal.com/article/S0026-0495(25)00018-6/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li S, Li H, Bennewitz K, Poschet G, Buettner M, Hausser I, Szendroedi J, Nawroth PP, Kroll J. Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis. Metabolism. 2025 Jan 30:156149. doi: 10.1016/j.metabol.2025.156149. Epub ahead of print. PMID: 39892865.

Peptidoglycan recognition protein PGRP-5 is involved in immune defence and neuro-behavioral disorders in zebrafish embryos

Authors:
Li X, Xiong G, Luo M, Mao S, Zhang R, Meng Z, Li J, Liao X
Citation:
PLoS One. 2025 Jan 31;20(1):e0315714. doi: 10.1371/journal.pone.0315714. PMID: 39888929; PMCID: PMC11785313
Epub:
Not Epub
Abstract:
Peptidoglycan recognition proteins (PGRPs) are the evolutionarily highly conserved class of pattern recognition receptors,...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11785313/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Xiong G, Luo M, Mao S, Zhang R, Meng Z, Li J, Liao X. Peptidoglycan recognition protein PGRP-5 is involved in immune defence and neuro-behavioral disorders in zebrafish embryos. PLoS One. 2025 Jan 31;20(1):e0315714. doi: 10.1371/journal.pone.0315714. PMID: 39888929; PMCID: PMC11785313.

Monocyte-Derived cxcl12 Guides a Directional Migration of Blood Vessels in Zebra Fish

Authors:
Lu X, Wang X, Li B, Wang X, Duan X, Liu D
Citation:
Arterioscler Thromb Vasc Biol. 2025 Jan 23. doi: 10.1161/ATVBAHA.124.321588. Epub ahead of print. PMID: 39846165
Epub:
Not Epub
Abstract:
Background: Sprouting blood vessels, reaching the aimed location, and establishing the proper connections are vital for...
Link:
https://www.ahajournals.org/doi/10.1161/ATVBAHA.124.321588
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu X, Wang X, Li B, Wang X, Duan X, Liu D. Monocyte-Derived cxcl12 Guides a Directional Migration of Blood Vessels in Zebra Fish. Arterioscler Thromb Vasc Biol. 2025 Jan 23. doi: 10.1161/ATVBAHA.124.321588. Epub ahead of print. PMID: 39846165.

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