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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12497 scientific papers returned from the database with the search filters currently being used below.

Phospholipase D2 Regulates Microtubule Acetylation by Modulating Gsk3β-Tau Signaling in Mouse Oocytes During Meiotic Maturation

Authors:
Zhang N, Tian Y, Xu X, Wang B, Lou S, Kang J, Li J, Liang Y, Weng J, Ma W
Citation:
Mol Reprod Dev. 2025 Aug;92(8):e70051. doi: 10.1002/mrd.70051. PMID: 40838360
Epub:
Not Epub
Abstract:
Phospholipase D2 (PLD2) modulates cytoskeletal dynamics and membrane trafficking processes by converting phosphatidylcholine (...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mrd.70051
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocytes
Citation Extract:
Zhang N, Tian Y, Xu X, Wang B, Lou S, Kang J, Li J, Liang Y, Weng J, Ma W. Phospholipase D2 Regulates Microtubule Acetylation by Modulating Gsk3β-Tau Signaling in Mouse Oocytes During Meiotic Maturation. Mol Reprod Dev. 2025 Aug;92(8):e70051. doi: 10.1002/mrd.70051. PMID: 40838360.

Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy

Authors:
Li Y, Singh N, Dong C, Sharma S, Zhou Z, Du J, Haouili M, Jiao Y, Hopewell E, Liu Y, Opyrchal M, Zhang X, Zhou B, Lu X
Citation:
Sci Immunol. 2025 Aug 22;10(110):eadr9933. doi: 10.1126/sciimmunol.adr9933. Epub 2025 Aug 22. PMID: 40845126.
Epub:
Not Epub
Abstract:
Regulatory T cells (Treg cells) represent a primary barrier to the development of effective antitumor immunity. Here, we report...
Link:
https://www.science.org/doi/10.1126/sciimmunol.adr9933
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
PMO-treated Treg splenic cells isolated from wild type or Foxp3dE2 mice co-cultured with human breast and colorectal cancer patient-derived tumor organoids
Citation Extract:
Li Y, Singh N, Dong C, Sharma S, Zhou Z, Du J, Haouili M, Jiao Y, Hopewell E, Liu Y, Opyrchal M, Zhang X, Zhou B, Lu X. Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy. Sci Immunol. 2025 Aug 22;10(110):eadr9933. doi: 10.1126/sciimmunol.adr9933. Epub 2025 Aug 22. PMID: 40845126..

Heparanase 2 Modulates Vascular Permeability via Heparan Sulfate-Dependent Growth Factor Signaling

Authors:
Becker Y, Tkachuk S, Jörns A, Shushakova N, Rong S, Alwakaa A, Hegermann J, Schenk H, Kiyan Y, Haller H
Citation:
Arterioscler Thromb Vasc Biol. 2025 Aug 21. doi: 10.1161/ATVBAHA.125.323060. Epub ahead of print. PMID: 40836917
Epub:
Not Epub
Abstract:
Background: Vessel-lining endothelial cells (ECs) rely on heparan sulfate (HS) proteoglycans to regulate vascular permeability...
Link:
https://www.ahajournals.org/doi/10.1161/ATVBAHA.125.323060
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Becker Y, Tkachuk S, Jörns A, Shushakova N, Rong S, Alwakaa A, Hegermann J, Schenk H, Kiyan Y, Haller H. Heparanase 2 Modulates Vascular Permeability via Heparan Sulfate-Dependent Growth Factor Signaling. Arterioscler Thromb Vasc Biol. 2025 Aug 21. doi: 10.1161/ATVBAHA.125.323060. Epub ahead of print. PMID: 40836917.

PTBP3 Associated With 9q32 Locus Is a Candidate Gene for Nager Syndrome

Authors:
Gonzalez JA, Devotta A, Hong CS, Griffin C, Saint-Jeannet JP
Citation:
Birth Defects Res. 2025 Aug;117(8):e2518. doi: 10.1002/bdr2.2518. PMID: 40820387
Epub:
Not Epub
Abstract:
Background: Mandibulofacial dysostosis (MFD) is a congenital disorder characterized by defects in facial bones of neural crest...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2518
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Gonzalez JA, Devotta A, Hong CS, Griffin C, Saint-Jeannet JP. PTBP3 Associated With 9q32 Locus Is a Candidate Gene for Nager Syndrome. Birth Defects Res. 2025 Aug;117(8):e2518. doi: 10.1002/bdr2.2518. PMID: 40820387.

Molecular Properties and Intramolecular interactions of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides

Authors:
Kliuchnikov E, Maksudov F, Pierson D, Marx KA, Chanda A, Barsegov V
Citation:
Molecular Therapy - Nucleic Acids (2025)
Epub:
Not Epub
Abstract:
We combined Circular Dichroism (CD) and viscosity measurements with MD simulations and classification and regression approaches...
Link:
https://www.sciencedirect.com/science/article/pii/S2162253125002392
Delivery Method:
peptide-linked
Citation Extract:
Kliuchnikov E, Maksudov F, Pierson D, Marx KA, Chanda A, Barsegov V. Molecular Properties and Intramolecular interactions of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Molecular Therapy - Nucleic Acids (2025).

Reelin/Disabled-1 Signalling Contributes to Functional Recovery on Zebrafish After Spinal Cord Injury

Authors:
Li R, Sahu S
Citation:
Int J Dev Neurosci. 2025 Aug;85(5):e70045. doi: 10.1002/jdn.70045. PMID: 40798876
Epub:
Not Epub
Abstract:
Reelin, an extracellular matrix glycoprotein, plays important roles in neural development. Mutation-induced loss of its...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/jdn.70045
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li R, Sahu S. Reelin/Disabled-1 Signalling Contributes to Functional Recovery on Zebrafish After Spinal Cord Injury. Int J Dev Neurosci. 2025 Aug;85(5):e70045. doi: 10.1002/jdn.70045. PMID: 40798876.

Guanidinium-linked morpholino-siRNA chimera: synthesis, biophysical properties and in vitro activity

Authors:
Gupta S, Ghosh A, Pratihar S, Mukherjee M, Kundu J, Sinha S
Citation:
Chem Commun (Camb). 2025 Aug 22. doi: 10.1039/d5cc03543k. Epub ahead of print. PMID: 40842421
Epub:
Not Epub
Abstract:
This study introduces guanidinium morpholino RNA (GMO-RNA), an RNA analogue with enhanced cell permeability, nuclease...
Link:
https://pubs.rsc.org/en/content/articlelanding/2025/cc/d5cc03543k
Organism or Cell Type:
cell culture: PC-3, DU 145, MDA-MB-231, MCF7, HepG2
Citation Extract:
Gupta S, Ghosh A, Pratihar S, Mukherjee M, Kundu J, Sinha S. Guanidinium-linked morpholino-siRNA chimera: synthesis, biophysical properties and in vitro activity. Chem Commun (Camb). 2025 Aug 22. doi: 10.1039/d5cc03543k. Epub ahead of print. PMID: 40842421.

A combinatorial oligonucleotide therapy to improve dystrophin restoration and dystrophin-deficient muscle health

Authors:
Moon YJ, Hindupur R, Gamu IH, McCormack NM, Shaikh F, Novak JS, Jaiswal JK
Citation:
Mol Ther Nucleic Acids. 2025 Aug 5;36(3):102665. doi: 10.1016/j.omtn.2025.102665. PMID: 40896584; PMCID: PMC12398789
Epub:
Not Epub
Abstract:
Despite the proven safety of dystrophin-targeting phosphorodiamidate morpholino oligomer (PMO) therapy, poor delivery of the...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(25)00219-7
Delivery Method:
intramuscular (i.m.) in the TA or intravenous (i.v.) in the retro-orbital sinus
Organism or Cell Type:
mdx mice
Citation Extract:
Moon YJ, Hindupur R, Gamu IH, McCormack NM, Shaikh F, Novak JS, Jaiswal JK. A combinatorial oligonucleotide therapy to improve dystrophin restoration and dystrophin-deficient muscle health. Mol Ther Nucleic Acids. 2025 Aug 5;36(3):102665. doi: 10.1016/j.omtn.2025.102665. PMID: 40896584; PMCID: PMC12398789.

A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids

Authors:
Waldrip ZJ, Burdine L, Peterson EC, Rainwater RR, Min Y, Burdine MS
Citation:
iScience preprint (2025), doi: https://doi.org/10.1016/j.isci.2025.113303
Epub:
Not Epub
Abstract:
There is untapped potential for medical breakthroughs using engineered microbes to treat conditions such as those of the...
Link:
https://www.cell.com/iscience/pdf/S2589-0042(25)01564-0.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Waldrip ZJ, Burdine L, Peterson EC, Rainwater RR, Min Y, Burdine MS. A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids. iScience preprint (2025), doi: https://doi.org/10.1016/j.isci.2025.113303.

A 3D genome compendium of breast cancer progression

Authors:
den Brand T, Collier MD, Flach KD, Gregoricchio S, Mayayo-Peralta I, Dauyey Z, Schuurman K, Teunissen H, Zwart W, de Wit E
Citation:
iScience (2025), doi: https://doi.org/10.1016/j.isci.2025.113268
Epub:
Not Epub
Abstract:
During cancer development and progression massive alterations in gene expression are observed. Gene regulation occurs within...
Link:
https://www.cell.com/iscience/pdf/S2589-0042(25)01529-9.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
den Brand T, Collier MD, Flach KD, Gregoricchio S, Mayayo-Peralta I, Dauyey Z, Schuurman K, Teunissen H, Zwart W, de Wit E. A 3D genome compendium of breast cancer progression. iScience (2025), doi: https://doi.org/10.1016/j.isci.2025.113268.

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