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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12497 scientific papers returned from the database with the search filters currently being used below.

Whole exome sequencing study of families with single atrium and/or single ventricle identifies de novo mutations in CORIN and TTLL10 as potential pathogenic genes

Authors:
Wu Y, Wang W, Zhou W, Ye B, Chen L, Tang P, Niu J, Han X, Sun X, Qin S, Wang Y
Citation:
Gene. 2025 Sep 22:149786. doi: 10.1016/j.gene.2025.149786. Epub ahead of print. PMID: 40992551
Epub:
Not Epub
Abstract:
Background: Single atrium and/or single ventricle (SA and/or SV) are severe congenital heart malformations linked to gene...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S037811192500575X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu Y, Wang W, Zhou W, Ye B, Chen L, Tang P, Niu J, Han X, Sun X, Qin S, Wang Y. Whole exome sequencing study of families with single atrium and/or single ventricle identifies de novo mutations in CORIN and TTLL10 as potential pathogenic genes. Gene. 2025 Sep 22:149786. doi: 10.1016/j.gene.2025.149786. Epub ahead of print. PMID: 40992551.

A novel phex gene variant causes non-syndromic tooth agenesis

Authors:
Pan Y, Hua B, Wang H, Tan S, Lu T, Xiong F, Ma D
Citation:
BMC Oral Health 25, 1452 (2025). https://doi.org/10.1186/s12903-025-06827-0
Epub:
Not Epub
Abstract:
Objectives For a long time, phosphate regulating endopeptidase X-linked (phex) gene variants have been considered the primary...
Link:
https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-06827-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pan Y, Hua B, Wang H, Tan S, Lu T, Xiong F, Ma D. A novel phex gene variant causes non-syndromic tooth agenesis. BMC Oral Health 25, 1452 (2025). https://doi.org/10.1186/s12903-025-06827-0.

EMB is essential for enteric nervous system development mediated by PI3K signaling

Authors:
Li Z, Zhuansun D, Meng X, Yang H, Xiao J, Chen Y, Wang J, Yu X, Li Z, You J, Chen X, Feng C, Wu L, Chu X, Duan W, Wang K, Li Z, Tou J, Yu L, Tang W, Liu Y, Jiang X, Ren H, Yu M, Yin Q, Liu X, Xu Z, Wu D, Jiao C, Yu D, Wu X, Zhu T, Yang J, Xiang L, Wang J, Wang Q, Zhou B, Wang D, Chen K, Mao H, Wang B, Zhan J, Wang CY, Zeng W, Chen F, Xiong B, Feng J
Citation:
Genome Med. 2025 Sep 25;17(1):102. doi: 10.1186/s13073-025-01538-1. PMID: 40999499
Epub:
Not Epub
Abstract:
Background: The enteric nervous system (ENS), which arises from enteric neural crest cells (ENCCs), plays important roles in...
Link:
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-025-01538-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li Z, Zhuansun D, Meng X, Yang H, Xiao J, Chen Y, Wang J, Yu X, Li Z, You J, Chen X, Feng C, Wu L, Chu X, Duan W, Wang K, Li Z, Tou J, Yu L, Tang W, Liu Y, Jiang X, Ren H, Yu M, Yin Q, Liu X, Xu Z, Wu D, Jiao C, Yu D, Wu X, Zhu T, Yang J, Xiang L, Wang J, Wang Q, Zhou B, Wang D, Chen K, Mao H, Wang B, Zhan J, Wang CY, Zeng W, Chen F, Xiong B, Feng J. EMB is essential for enteric nervous system development mediated by PI3K signaling. Genome Med. 2025 Sep 25;17(1):102. doi: 10.1186/s13073-025-01538-1. PMID: 40999499.

Role of DENN Domain-Containing Protein 5b (dennd5b) during early embryonic development of zebrafish

Authors:
Mendoza A, Nassar KM, Marston M, Gil A, Hasan S
Citation:
Mol Biol Rep. 2025 Sep 25;52(1):947. doi: 10.1007/s11033-025-11023-y. PMID: 40996562
Epub:
Not Epub
Abstract:
Prior studies on non-canonical Wnt signaling have established Dishevelled Associated Activator of Morphogenesis 1 (Daam1) as a...
Link:
https://link.springer.com/article/10.1007/s11033-025-11023-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mendoza A, Nassar KM, Marston M, Gil A, Hasan S. Role of DENN Domain-Containing Protein 5b (dennd5b) during early embryonic development of zebrafish. Mol Biol Rep. 2025 Sep 25;52(1):947. doi: 10.1007/s11033-025-11023-y. PMID: 40996562.

WDR5 and Myc Cooperate to Regulate Formation of Neural Crest Stem Cells

Authors:
Compton K, Barter E, LaBonne C
Citation:
bioRxiv [preprint] 2025.09.19.677424; doi: https://doi.org/10.1101/2025.09.19.677424
Epub:
Not Epub
Abstract:
WDR5 is a multifunctional scaffolding protein with established roles in chromatin regulation and pluripotency, but its...
Link:
https://www.biorxiv.org/content/10.1101/2025.09.19.677424v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Compton K, Barter E, LaBonne C. WDR5 and Myc Cooperate to Regulate Formation of Neural Crest Stem Cells. bioRxiv [preprint] 2025.09.19.677424; doi: https://doi.org/10.1101/2025.09.19.677424.

Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple-negative breast cancer in female mice

Authors:
Feliz-Mosquea YR, Wilson AS, Cruz-Diaz N, Payne VS, Cook KL, Soto-Pantoja DR
Citation:
Physiol Rep. 2025 Sep;13(18):e70400. doi: 10.14814/phy2.70400. PMID: 40976979; PMCID: PMC12451018
Epub:
Not Epub
Abstract:
Triple-negative breast cancer (TNBC) predominantly affects young and minority women, with cytotoxic chemotherapy regimens...
Link:
https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70400
Delivery Method:
intraperitoneal (i.p.)
Organism or Cell Type:
BALB/c mice with 4T1 tumor explants
Citation Extract:
Feliz-Mosquea YR, Wilson AS, Cruz-Diaz N, Payne VS, Cook KL, Soto-Pantoja DR. Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple-negative breast cancer in female mice. Physiol Rep. 2025 Sep;13(18):e70400. doi: 10.14814/phy2.70400. PMID: 40976979; PMCID: PMC12451018.

Antisense phosphorodiamidate morpholino oligomers retain activity in Burkholderia cepacia complex biofilm

Authors:
Mendez AR, Pybus C, Greenberg DE
Citation:
Frontiers in Microbiology. Volume 16 - 2025, 2025. doi: 10.3389/fmicb.2025.1660799
Epub:
Not Epub
Abstract:
Background: Members of the Burkholderia cepacia complex (Bcc) are known to cause severe pulmonary infections in...
Link:
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1660799
Delivery Method:
peptide-linked
Organism or Cell Type:
Burkholderia cepacia
Citation Extract:
Mendez AR, Pybus C, Greenberg DE. Antisense phosphorodiamidate morpholino oligomers retain activity in Burkholderia cepacia complex biofilm. Frontiers in Microbiology. Volume 16 - 2025, 2025. doi: 10.3389/fmicb.2025.1660799.

Reactive Oxygen Species Counteract Zebrafish Wound Contraction and Promote Wound Healing

Authors:
Ding C, Li L, Wang Y, Nguyen HA, Chan DD, Umulis DM, Buganza AT, Deng Q
Citation:
Biophys J. 2025 Sep 19:S0006-3495(25)00607-1. doi: 10.1016/j.bpj.2025.09.027. Epub ahead of print. PMID: 40975783
Epub:
Not Epub
Abstract:
Reactive oxygen species (ROS) are second messengers that drive wound closure. However, the mechanism by which ROS regulate...
Link:
https://www.sciencedirect.com/science/article/pii/S0006349525006071
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding C, Li L, Wang Y, Nguyen HA, Chan DD, Umulis DM, Buganza AT, Deng Q. Reactive Oxygen Species Counteract Zebrafish Wound Contraction and Promote Wound Healing. Biophys J. 2025 Sep 19:S0006-3495(25)00607-1. doi: 10.1016/j.bpj.2025.09.027. Epub ahead of print. PMID: 40975783.

Bone morphogenetic protein-mediated Ventx3.2 regulates mesendoderm patterning and gut morphogenesis during Xenopus embryogenesis

Authors:
Goutam RS, Kumar V, Lee U, Kim J
Citation:
Biochem Biophys Res Commun. 2025 Sep 10;784:152623. doi: 10.1016/j.bbrc.2025.152623. Epub ahead of print. PMID: 40967030
Epub:
Not Epub
Abstract:
Bone morphogenetic protein (BMP) signaling plays a pivotal role in germ layer specification and organogenesis during vertebrate...
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X25013397
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Goutam RS, Kumar V, Lee U, Kim J. Bone morphogenetic protein-mediated Ventx3.2 regulates mesendoderm patterning and gut morphogenesis during Xenopus embryogenesis. Biochem Biophys Res Commun. 2025 Sep 10;784:152623. doi: 10.1016/j.bbrc.2025.152623. Epub ahead of print. PMID: 40967030.

Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease

Authors:
Chembazhi UV, Bangru S, Dutta RK, Das D, Peiffer B, Natua S, Toohill K, Leona A, Purwar I, Bhowmik A, Goyal Y, Sun Z, Diehl AM, Kalsotra A
Citation:
Nat Commun. 2025 Sep 10;16(1):8049. doi: 10.1038/s41467-025-63251-2. PMID: 40931030; PMCID: PMC12423296
Epub:
Not Epub
Abstract:
Individuals with progressive liver failure risk dying without liver transplantation. However, our understanding of why...
Link:
https://www.nature.com/articles/s41467-025-63251-2
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: AML12
Citation Extract:
Chembazhi UV, Bangru S, Dutta RK, Das D, Peiffer B, Natua S, Toohill K, Leona A, Purwar I, Bhowmik A, Goyal Y, Sun Z, Diehl AM, Kalsotra A. Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease. Nat Commun. 2025 Sep 10;16(1):8049. doi: 10.1038/s41467-025-63251-2. PMID: 40931030; PMCID: PMC12423296.

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