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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio)

Authors:
Tuttle M, Dalman MR, Liu Q, Londraville RL
Citation:
PeerJ. 2019;7:e6848 doi:10.7717/peerj.6848
Epub:
Not Epub
Abstract:
We analyzed microarray expression data to highlight biological pathways that respond to embryonic zebrafish Leptin-a (lepa)...
Link:
https://peerj.com/articles/6848/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tuttle M, Dalman MR, Liu Q, Londraville RL. Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio). PeerJ. 2019;7:e6848 doi:10.7717/peerj.6848.

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides in vitro and in mdx Mice

Authors:
Wang M, Wu B, Shah SN, Lu P, Lu Q
Citation:
Molec Ther Nucl Acids. 2019;16:663-674 doi:10.1016/j.omtn.2019.04.023
Epub:
Yes
Abstract:
Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy with ongoing clinical...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30096-4
Delivery Method:
Endo-Porter, aminoglycoside
Organism or Cell Type:
cell culture, mice mdx
Citation Extract:
Wang M, Wu B, Shah SN, Lu P, Lu Q. Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides in vitro and in mdx Mice. Molec Ther Nucl Acids. 2019;16:663-674 doi:10.1016/j.omtn.2019.04.023.

BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress

Authors:
Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L
Citation:
Cancer Discov. 2019 May;9(5):662-679. doi: 10.1158/2159-8290.CD-17-1444. Epub 2019 Feb 18
Epub:
Not Epub
Abstract:
Several lines of evidence link the canonical oncogene BCL6 to stress response. Here we demonstrate that BCL6 evolved in...
Link:
http://cancerdiscovery.aacrjournals.org/content/9/5/662
Organism or Cell Type:
zebrafish
Citation Extract:
Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L. BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress. Cancer Discov. 2019 May;9(5):662-679. doi: 10.1158/2159-8290.CD-17-1444. Epub 2019 Feb 18.

Barhl2 maintains T-cell factors as repressors, and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation

Authors:
Sena E, Rocques N, Borday C, Amin HSM, Parain K, Sitbon D, Chesneau A, Durand BC
Citation:
Development. 2019 Apr 29. pii: dev.173112. doi: 10.1242/dev.173112. [Epub ahead of print]
Epub:
Yes
Abstract:
A hallmark of Wnt/β-Catenin signaling is the extreme diversity of its transcriptional response, which varies depending on cell...
Link:
http://dev.biologists.org/content/early/2019/04/26/dev.173112
Citation Extract:
Sena E, Rocques N, Borday C, Amin HSM, Parain K, Sitbon D, Chesneau A, Durand BC. Barhl2 maintains T-cell factors as repressors, and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation. Development. 2019 Apr 29. pii: dev.173112. doi: 10.1242/dev.173112. [Epub ahead of print].

A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis

Authors:
Xue Y, Liu D, Cui G, Ding Y, Ai D, Gao S, Zhang Y, Suo S, Wang X, Lv P, Zhou C, Li Y, Chen X, Peng G, Jing N, Han JJ, Liu F
Citation:
Cell Rep. 2019 Apr 30;27(5):1567-1578.e5. doi: 10.1016/j.celrep.2019.04.030
Epub:
Not Epub
Abstract:
In vertebrates, hematopoiesis occurring in different niches is orchestrated by intrinsic and extrinsic regulators. Previous...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30495-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xue Y, Liu D, Cui G, Ding Y, Ai D, Gao S, Zhang Y, Suo S, Wang X, Lv P, Zhou C, Li Y, Chen X, Peng G, Jing N, Han JJ, Liu F. A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Rep. 2019 Apr 30;27(5):1567-1578.e5. doi: 10.1016/j.celrep.2019.04.030.

Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorates disease like phenotypes in embryo

Authors:
Asad Z, Sachidanandan C
Citation:
Eur J Med Genet. 2019 Apr 30. pii: S1769-7212(19)30015-1. doi: 10.1016/j.ejmg.2019.04.018. [Epub ahead of print]
Epub:
Yes
Abstract:
CHARGE syndrome is an autosomal dominant congenital disorder caused primarily by mutations in the CHD7 gene. Using a small...
Link:
https://www.sciencedirect.com/science/article/pii/S1769721219300151
Organism or Cell Type:
zebrafish
Citation Extract:
Asad Z, Sachidanandan C. Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorates disease like phenotypes in embryo. Eur J Med Genet. 2019 Apr 30. pii: S1769-7212(19)30015-1. doi: 10.1016/j.ejmg.2019.04.018. [Epub ahead of print].

Combinatorial control of gene function with wavelength-selective caged morpholinos

Authors:
Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK
Citation:
Meth Enzymol. 2019;624:69-88. doi: 10.1016/bs.mie.2019.04.007
Epub:
Yes
Abstract:
Caged morpholino oligonucleotides (cMOs) are useful research tools in developmental biology because they allow spatiotemporal...
Link:
https://www.sciencedirect.com/science/article/pii/S0076687919301223
Citation Extract:
Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK. Combinatorial control of gene function with wavelength-selective caged morpholinos. Meth Enzymol. 2019;624:69-88. doi: 10.1016/bs.mie.2019.04.007.

The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage

Authors:
Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM
Citation:
Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi:10.1016/j.devcel.2019.03.017
Epub:
Not Epub
Abstract:
The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification....
Link:
https://www.sciencedirect.com/science/article/abs/pii/S153458071930228X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM. The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi:10.1016/j.devcel.2019.03.017.

Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans

Authors:
DeRossi C, Bambino K, Morrison J, Sakarin I, Villacorta-Martin C, Zhang C, Ellis JL, Fiel MI, Ybanez M, Lee YA, Huang KL, Yin C, Sakaguchi TF, Friedman SL, Villanueva A, Chu J
Citation:
Hepatology. 2019 Dec;70(6):2107-2122. doi: 10.1002/hep.30677. Epub 2019 May 24. PMID: 31016744; PMCID: PMC6812593
Epub:
Not Epub
Abstract:
The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6812593/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
DeRossi C, Bambino K, Morrison J, Sakarin I, Villacorta-Martin C, Zhang C, Ellis JL, Fiel MI, Ybanez M, Lee YA, Huang KL, Yin C, Sakaguchi TF, Friedman SL, Villanueva A, Chu J. Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. Hepatology. 2019 Dec;70(6):2107-2122. doi: 10.1002/hep.30677. Epub 2019 May 24. PMID: 31016744; PMCID: PMC6812593.

AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair

Authors:
Pei D-S, Jia P-P, Luo J-J, Liu W, Strauss PR
Citation:
Cell Death Dis. 2019:10(5):348. doi:10.1038/s41419-019-1578-1
Epub:
Not Epub
Abstract:
Brain and neurons are particularly sensitive to reactive oxygen species (ROS). Oxidative damage from ROS results in increased 8...
Link:
https://www.nature.com/articles/s41419-019-1578-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pei D-S, Jia P-P, Luo J-J, Liu W, Strauss PR . AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Cell Death Dis. 2019:10(5):348. doi:10.1038/s41419-019-1578-1.

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