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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

An interaction between myosin-10 and the cell cycle regulator Wee1 links spindle dynamics to mitotic progression in epithelia

Authors:
Sandquist JC, Larson ME, Woolner S, Ding Z, Bement WM
Citation:
J Cell Biol. 2018 Jan 10. pii: jcb.201708072. doi: 10.1083/jcb.201708072. [Epub ahead of print]
Epub:
Yes
Abstract:
Anaphase in epithelia typically does not ensue until after spindles have achieved a characteristic position and orientation,...
Link:
http://jcb.rupress.org/content/early/2018/01/09/jcb.201708072
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Sandquist JC, Larson ME, Woolner S, Ding Z, Bement WM. An interaction between myosin-10 and the cell cycle regulator Wee1 links spindle dynamics to mitotic progression in epithelia. J Cell Biol. 2018 Jan 10. pii: jcb.201708072. doi: 10.1083/jcb.201708072. [Epub ahead of print].

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure

Authors:
Cao M, Ouyang J, Guo J, Lin S, Chen S
Citation:
Invest Ophthalmol Vis Sci. 2018;59:1167-77. doi:10.1167/iovs.17-22827
Epub:
Not Epub
Abstract:
Purpose: Coloboma is a sight-threatening congenital eye disease caused by a failure in optic fissure (OF) closure. The aim of...
Link:
http://iovs.arvojournals.org/article.aspx?articleid=2674330
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cao M, Ouyang J, Guo J, Lin S, Chen S. Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure. Invest Ophthalmol Vis Sci. 2018;59:1167-77. doi:10.1167/iovs.17-22827 .

Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders

Authors:
Calo E, Gu B, Bowen ME, Aryan F, Zalc A, Liang J, Flynn RA, Swigut T, Chang HY, Attardi LD, Wysocka J
Citation:
Nature. 2018 Feb 1;554(7690):112-117. doi: 10.1038/nature25449. Epub 2018 Jan 24
Epub:
Not Epub
Abstract:
Many craniofacial disorders are caused by heterozygous mutations in general regulators of housekeeping cellular functions such...
Link:
https://www.nature.com/articles/nature25449
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus, zebrafish
Citation Extract:
Calo E, Gu B, Bowen ME, Aryan F, Zalc A, Liang J, Flynn RA, Swigut T, Chang HY, Attardi LD, Wysocka J. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 2018 Feb 1;554(7690):112-117. doi: 10.1038/nature25449. Epub 2018 Jan 24.

The transcription factor Dach1 is essential for podocyte function

Authors:
Endlich N, Kliewe F, Kindt F, Schmidt K, Kotb AM, Artelt N, Lindenmeyer MT, Cohen CD, Döring F, Kuss AW, Amann K, Moeller MJ, Kabgani N, Blumenthal A, Endlich K
Citation:
J Cell Mol Med. 2018 Mar 2. doi: 10.1111/jcmm.13544. [Epub ahead of print]
Epub:
Yes
Abstract:
Dedifferentiation and loss of podocytes are the major cause of chronic kidney disease. Dach1, a transcription factor that is...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/jcmm.13544/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Endlich N, Kliewe F, Kindt F, Schmidt K, Kotb AM, Artelt N, Lindenmeyer MT, Cohen CD, Döring F, Kuss AW, Amann K, Moeller MJ, Kabgani N, Blumenthal A, Endlich K. The transcription factor Dach1 is essential for podocyte function. J Cell Mol Med. 2018 Mar 2. doi: 10.1111/jcmm.13544. [Epub ahead of print].

Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity

Authors:
Lange M, Froc C, Grunwald H, Norton WHJ, Bally-Cuif L
Citation:
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 26. pii: S0278-5846(17)30733-9. doi: 10.1016/j.pnpbp.2018.02.010. [Epub ahead of print]
Epub:
Yes
Abstract:
Polymorphisms in the gene coding for the adhesion G-protein coupled receptor LPHN3 are a risk factor for attention-deficit/...
Link:
https://www.sciencedirect.com/science/article/pii/S0278584617307339
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lange M, Froc C, Grunwald H, Norton WHJ, Bally-Cuif L. Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 26. pii: S0278-5846(17)30733-9. doi: 10.1016/j.pnpbp.2018.02.010. [Epub ahead of print].

chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis

Authors:
Rojas-Muñoz A, Dahm R, Nüsslein-Volhard C
Citation:
Dev Biol. 2005 Dec 15;288(2):348-62. Epub 2005 Nov 21
Epub:
Not Epub
Abstract:
Despite the importance of the retinal pigment epithelium (RPE) for vision, the molecular processes involved in its...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160605005932
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rojas-Muñoz A, Dahm R, Nüsslein-Volhard C. chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis. Dev Biol. 2005 Dec 15;288(2):348-62. Epub 2005 Nov 21.

Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae

Authors:
Geller BL, Li L, Martinez F, Sully E, Sturge CR, Daly SM, Pybus C, Greenberg DE
Citation:
J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058
Epub:
Yes
Abstract:
Background: Klebsiella pneumoniae is an opportunistic pathogen and many strains are multidrug resistant. KPC is one of the most...
Link:
https://academic.oup.com/jac/advance-article-abstract/doi/10.1093/jac/dky058/4915983
Delivery Method:
peptide-linked
Organism or Cell Type:
Klebsiella pneumoniae
Citation Extract:
Geller BL, Li L, Martinez F, Sully E, Sturge CR, Daly SM, Pybus C, Greenberg DE. Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae. J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058.

[An improved method for in vivo electroporation of morpholinos into the adult zebrafish retina]

Authors:
Hou HT, Lv JY, Zhang ZQ, Lu Y, Zhou CP, Zhou TQ, Zhang SQ, Xu H
Citation:
Sheng Li Xue Bao. 2018 Feb 25;70(1):47-51. Chinese
Epub:
Not Epub
Abstract:
In vivo electroporation of morpholinos (MOs) into the retina of adult zebrafish is an efficient method to study gene function...
Link:
https://www.ncbi.nlm.nih.gov/pubmed/29492514
Delivery Method:
electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Hou HT, Lv JY, Zhang ZQ, Lu Y, Zhou CP, Zhou TQ, Zhang SQ, Xu H. [An improved method for in vivo electroporation of morpholinos into the adult zebrafish retina]. Sheng Li Xue Bao. 2018 Feb 25;70(1):47-51. Chinese.

A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis

Authors:
Christov CP, Dingwell KS, Skehel M, Wilkes HS, Sale JE, Smith JC, Krude T
Citation:
Cell Rep. 2018;22(9):2265-2278. doi:10.1016/j.celrep.2018.02.015
Epub:
Not Epub
Abstract:
DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-...
Link:
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30183-9
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Christov CP, Dingwell KS, Skehel M, Wilkes HS, Sale JE, Smith JC, Krude T. A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis. Cell Rep. 2018;22(9):2265-2278. doi:10.1016/j.celrep.2018.02.015.

GAA-TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one

Authors:
Halabi A, Fuselier KTB, Grabczyk E
Citation:
Nucl Acid Res. 2018;[Epub ahead of print] doi:/10.1093/nar/gky143
Epub:
Yes
Abstract:
DNA repeat expansion underlies dozens of progressive neurodegenerative disorders. While the mechanisms driving repeat expansion...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky143/4909995
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Halabi A, Fuselier KTB, Grabczyk E. GAA-TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one. Nucl Acid Res. 2018;[Epub ahead of print] doi:/10.1093/nar/gky143.

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