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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12221 scientific papers returned from the database with the search filters currently being used below.

Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation

Authors:
Tuazon FB, Wang X, Andrade JL, Umulis D, Mullins MC
Citation:
Cell Rep. 2020;32(7):108039. doi:10.1016/j.celrep.2020.108039
Epub:
Not Epub
Abstract:
A fundamental question in developmental biology is how morphogens, such as bone morphogenetic protein (BMP), form precise...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31024-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tuazon FB, Wang X, Andrade JL, Umulis D, Mullins MC. Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation. Cell Rep. 2020;32(7):108039. doi:10.1016/j.celrep.2020.108039.

In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy

Authors:
Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li H, Li Y, Liu L, Huang J, Liu L, Peng C, Kaindl AM, Gecz J, Han D, Liu D, Xu K, Hu H
Citation:
Brain. 2022 Mar 29;145(1):119-141. doi: 10.1093/brain/awab209. PMID: 34077496; PMCID: PMC8967106
Epub:
Not Epub
Abstract:
Cerebral palsy is the most prevalent physical disability in children; however, its inherent molecular mechanisms remain unclear...
Link:
https://academic.oup.com/brain/article/145/1/119/6291242
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li H, Li Y, Liu L, Huang J, Liu L, Peng C, Kaindl AM, Gecz J, Han D, Liu D, Xu K, Hu H. In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy. Brain. 2022 Mar 29;145(1):119-141. doi: 10.1093/brain/awab209. PMID: 34077496; PMCID: PMC8967106.

Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy

Authors:
Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester DJ, Giudicessi JR, Jiang K, Ackerman MJ, Li Y, Wang DW, Lee HC, Wang DW, Xu X
Citation:
J Am Heart Assoc. 2020 Aug 18:e017055. doi:10.1161/JAHA.119.017055. Online ahead of print
Epub:
Yes
Abstract:
Background Sorbs2b (sorbin and SH3 domain-containing 2b) was recently identified as a cardiomyopathy gene from a zebrafish...
Link:
https://www.ahajournals.org/doi/10.1161/JAHA.119.017055
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester DJ, Giudicessi JR, Jiang K, Ackerman MJ, Li Y, Wang DW, Lee HC, Wang DW, Xu X. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. J Am Heart Assoc. 2020 Aug 18:e017055. doi:10.1161/JAHA.119.017055. Online ahead of print.

The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos

Authors:
Layous M, Khalaily L, Gildor T, Ben-Tabou de-Leon S
Citation:
Development. 2021 Apr 15;148(8):dev195859. doi: 10.1242/dev.195859. Epub 2021 Apr 19. PMID: 33795230; PMCID: PMC8077511
Epub:
Not Epub
Abstract:
Deoxygenation, the reduction of oxygen level in the oceans induced by global warming and anthropogenic disturbances, is a major...
Link:
https://journals.biologists.com/dev/article/148/8/dev195859/238104/The-tolerance-to-hypoxia-is-defined-by-a-time
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Layous M, Khalaily L, Gildor T, Ben-Tabou de-Leon S. The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos. Development. 2021 Apr 15;148(8):dev195859. doi: 10.1242/dev.195859. Epub 2021 Apr 19. PMID: 33795230; PMCID: PMC8077511.

A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination

Authors:
Fiuza UM, Negishi T, Rouan A, Yasuo H, Lemaire P
Citation:
Development. 2020;[Epub ahead of print]. doi: 10.1242/dev.186965
Epub:
Yes
Abstract:
Gastrulation is the first major morphogenetic event during animal embryogenesis. Ascidian gastrulation starts with the...
Link:
https://dev.biologists.org/content/147/15/dev186965
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Fiuza UM, Negishi T, Rouan A, Yasuo H, Lemaire P. A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination. Development. 2020;[Epub ahead of print]. doi: 10.1242/dev.186965.

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

Authors:
Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi M, Jing R, Shwartz A, Goessling W, Daley GQ, North TE
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.07.015
Epub:
Yes
Abstract:
Embryonic hematopoietic stem and progenitor cells (HSPCs) robustly proliferate while maintaining multilineage potential in vivo...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S153458072030589X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi M, Jing R, Shwartz A, Goessling W, Daley GQ, North TE. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.07.015.

De novo phosphoinositide synthesis in zebrafish is required for triad formation but not essential for myogenesis

Authors:
Smith L, Fabian L, Al-Maawali A, Noche RR, Dowling JJ
Citation:
PLoS ONE. 2020;15(8):e0231364. doi:10.1371/journal.pone.0231364
Epub:
Not Epub
Abstract:
Phosphoinositides (PIPs) and their regulatory enzymes are key players in many cellular processes and are required for aspects...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231364
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Smith L, Fabian L, Al-Maawali A, Noche RR, Dowling JJ. De novo phosphoinositide synthesis in zebrafish is required for triad formation but not essential for myogenesis. PLoS ONE. 2020;15(8):e0231364. doi:10.1371/journal.pone.0231364.

Pathogenic variants in IMPG1 cause autosomal dominant and autosomal recessive retinitis pigmentosa

Authors:
Olivier G, Corton M, Intartaglia D, Verbakel SK, Sergouniotis PI, Le Meur G, Dhaenens C-M, Naacke H, Avila-Fernández A, Hoyng CB, Klevering J, Bocquet B, Roubertie A, Sénéchal A, Banfi S, Muller A, Hamel CL, Black GC, Conte I, Roosing S, Zanlonghi X, Ayuso C, Meunier I, Manes G
Citation:
J Med Genet. 2020;[Epub ahead of print] doi: 10.1136/jmedgenet-2020-107150
Epub:
Yes
Abstract:
Background: Inherited retinal disorders are a clinically and genetically heterogeneous group of conditions and a major cause of...
Link:
https://jmg.bmj.com/content/early/2020/08/17/jmedgenet-2020-107150
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Olivier G, Corton M, Intartaglia D, Verbakel SK, Sergouniotis PI, Le Meur G, Dhaenens C-M, Naacke H, Avila-Fernández A, Hoyng CB, Klevering J, Bocquet B, Roubertie A, Sénéchal A, Banfi S, Muller A, Hamel CL, Black GC, Conte I, Roosing S, Zanlonghi X, Ayuso C, Meunier I, Manes G. Pathogenic variants in IMPG1 cause autosomal dominant and autosomal recessive retinitis pigmentosa. J Med Genet. 2020;[Epub ahead of print] doi: 10.1136/jmedgenet-2020-107150.

CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos

Authors:
Kushawah G, Hernandez-Huertas L, del Prado JA-N, Martinez-Morales JR, DeVore ML, Huzaifa Hassan H, Moreno-Sanchez I, Tomas-Gallardo L, Diaz-Moscoso A, Monges DE, Guelfo JR, Theune WC, Brannan EO, Wang W, Corbin TJ, Moran AM, Alvarado AS, Málaga-Trillo E, Takacs CM, Bazzini AA, Moreno-Mateos MA
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.07.013
Epub:
Not Epub
Abstract:
Early embryonic development is driven exclusively by maternal gene products deposited into the oocyte. Although critical in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580720305876
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kushawah G, Hernandez-Huertas L, del Prado JA-N, Martinez-Morales JR, DeVore ML, Huzaifa Hassan H, Moreno-Sanchez I, Tomas-Gallardo L, Diaz-Moscoso A, Monges DE, Guelfo JR, Theune WC, Brannan EO, Wang W, Corbin TJ, Moran AM, Alvarado AS, Málaga-Trillo E, Takacs CM, Bazzini AA, Moreno-Mateos MA. CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.07.013.

Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway

Authors:
Sun J, Yoon J, Lee M, Hwang YS, Daar IO
Citation:
Sci Rep. 2020 Aug 13;10(1):13752. doi: 10.1038/s41598-020-70670-2
Epub:
Not Epub
Abstract:
Sproutys are negative regulators of the Ras/Raf/MAPK signaling pathway and involved in regulation of organogenesis,...
Link:
https://www.nature.com/articles/s41598-020-70670-2
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Sun J, Yoon J, Lee M, Hwang YS, Daar IO. Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway. Sci Rep. 2020 Aug 13;10(1):13752. doi: 10.1038/s41598-020-70670-2.

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