You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

PMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD)

Authors:
Sengupta K, Loro E, Khurana TS
Citation:
Sci Rep. 2020;10(1):21492. doi:10.1038/s41598-020-76338-1
Epub:
Not Epub
Abstract:
Upregulation of utrophin, a dystrophin related protein, is considered a promising therapeutic approach for Duchenne muscular...
Link:
https://www.nature.com/articles/s41598-020-76338-1
Delivery Method:
injection
Organism or Cell Type:
mice (mdx)
Citation Extract:
Sengupta K, Loro E, Khurana TS. PMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD). Sci Rep. 2020;10(1):21492. doi:10.1038/s41598-020-76338-1.

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo

Authors:
Floc'hlay S, Jimenez MDM, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D
Citation:
Development. 2021;148: dev189944 [Epub ahead of print] doi:10.1242/dev.189944
Epub:
Yes
Abstract:
During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral...
Link:
https://dev.biologists.org/content/early/2020/12/03/dev.189944
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Floc'hlay S, Jimenez MDM, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D. Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo. Development. 2021;148: dev189944 [Epub ahead of print] doi:10.1242/dev.189944.

Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

Authors:
Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Munoz N, Albrecht LV, Sosa E, Wohlschlegel JA, De Robertis EM
Citation:
Sci Rep. 2020;10(1):21555 doi:10.1038/s41598-020-78019-5
Epub:
Not Epub
Abstract:
The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including β-catenin signaling, differentiation...
Link:
https://www.nature.com/articles/s41598-020-78019-5
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Munoz N, Albrecht LV, Sosa E, Wohlschlegel JA, De Robertis EM. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway. Sci Rep. 2020;10(1):21555 doi:10.1038/s41598-020-78019-5.

Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos

Authors:
Geng F-S, de la Calle-Mustienes E, Gómez-Skarmeta JL, Lister R, Bogdanovic O
Citation:
microPublication Biology. 2020; doi:10.17912/micropub.biology.000341
Epub:
Not Epub
Abstract:
no abstract available Figure 1. Morpholino (MO) knockdown of foxk1/foxk2a/foxk2b and transcriptional profiling of...
Link:
https://www.micropublication.org/journals/biology/micropub-biology-000341/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geng F-S, de la Calle-Mustienes E, Gómez-Skarmeta JL, Lister R, Bogdanovic O. Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos. microPublication Biology. 2020; doi:10.17912/micropub.biology.000341.

Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b

Authors:
Dalgin G, Prince VE
Citation:
Dev Biol. 2020 Dec 5:S0012-1606(20)30310-9. doi: 10.1016/j.ydbio.2020.12.001. Online ahead of print
Epub:
Yes
Abstract:
During vertebrate embryonic development complex morphogenetic events drive the formation of internal organs associated with the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160620303109
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dalgin G, Prince VE. Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Dev Biol. 2020 Dec 5:S0012-1606(20)30310-9. doi: 10.1016/j.ydbio.2020.12.001. Online ahead of print.

Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos

Authors:
Ketharnathan S, Labudina A, Horsfield JA
Citation:
Front Cell Dev Biol. 2020;8:1542. doi:10.3389/fcell.2020.617545
Epub:
Not Epub
Abstract:
Cohesin is a multiprotein complex made up of core subunits Smc1, Smc3, and Rad21, and either Stag1 or Stag2. Normal...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.617545/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ketharnathan S, Labudina A, Horsfield JA. Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Front Cell Dev Biol. 2020;8:1542. doi:10.3389/fcell.2020.617545.

Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy

Authors:
Mendell JR, Goemans N, Lowes LP, Alfano LN, Berry K, Shao J, Kaye EM, Mercuri E; Eteplirsen Study Group and Telethon Foundation DMD Italian Network
Citation:
Ann Neurol. 2016 Feb;79(2):257-71. doi: 10.1002/ana.24555. Epub 2016 Jan 8
Epub:
Not Epub
Abstract:
Objective: To continue evaluation of the long-term efficacy and safety of eteplirsen, a phosphorodiamidate morpholino oligomer...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/ana.24555
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Mendell JR, Goemans N, Lowes LP, Alfano LN, Berry K, Shao J, Kaye EM, Mercuri E; Eteplirsen Study Group and Telethon Foundation DMD Italian Network. Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy. Ann Neurol. 2016 Feb;79(2):257-71. doi: 10.1002/ana.24555. Epub 2016 Jan 8.

Autosomal recessive cardiomyopathy and sudden cardiac death associated with variants in MYL3

Authors:
Osborn DPS, Emrahi L, Clayton J, Tabrizi MT, Wan AYB, Maroofian R, Yazdchi M, Garcia MLE, Galehdari H, Hesse C, Shariati G, Mazaheri N, Sedaghat A, Goullée H, Laing N, Jamshidi Y, Tajsharghi H
Citation:
Genet Med. 2020 Dec 8. doi: 10.1038/s41436-020-01028-2. Online ahead of print
Epub:
Yes
Abstract:
Purpose: Variants in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, the...
Link:
https://www.nature.com/articles/s41436-020-01028-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Osborn DPS, Emrahi L, Clayton J, Tabrizi MT, Wan AYB, Maroofian R, Yazdchi M, Garcia MLE, Galehdari H, Hesse C, Shariati G, Mazaheri N, Sedaghat A, Goullée H, Laing N, Jamshidi Y, Tajsharghi H. Autosomal recessive cardiomyopathy and sudden cardiac death associated with variants in MYL3. Genet Med. 2020 Dec 8. doi: 10.1038/s41436-020-01028-2. Online ahead of print.

A role for Cep70 in centriole amplification in multiciliated cells

Authors:
Kim SK, Brotslaw E, Thome V, Mitchell J, Ventrella R, Collins C, Mitchell B
Citation:
Dev Biol. 2020;471:10-17. doi: 10.1016/j.ydbio.2020.11.011. Online ahead of print
Epub:
Not Epub
Abstract:
Centriole amplification in multiciliated cells occurs in a pseudo-cell cycle regulated process that typically utilizes a poorly...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160620303092
Organism or Cell Type:
Xenopus
Citation Extract:
Kim SK, Brotslaw E, Thome V, Mitchell J, Ventrella R, Collins C, Mitchell B. A role for Cep70 in centriole amplification in multiciliated cells. Dev Biol. 2020;471:10-17. doi: 10.1016/j.ydbio.2020.11.011. Online ahead of print.

Viltolarsen in Japanese Duchenne muscular dystrophy patients: A phase 1/2 study

Authors:
Komaki H, Takeshima Y, Matsumura T, Ozasa S, Funato M, Takeshita E, Iwata Y, Yajima H, Egawa Y, Toramoto T, Tajima M, Takeda S
Citation:
Ann Clin Transl Neurol. 2020 Dec 7. doi: 10.1002/acn3.51235. Online ahead of print
Epub:
Yes
Abstract:
Objective: The novel morpholino antisense oligonucleotide viltolarsen targets exon 53 of the dystrophin gene, and could be an...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/acn3.51235
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Komaki H, Takeshima Y, Matsumura T, Ozasa S, Funato M, Takeshita E, Iwata Y, Yajima H, Egawa Y, Toramoto T, Tajima M, Takeda S. Viltolarsen in Japanese Duchenne muscular dystrophy patients: A phase 1/2 study. Ann Clin Transl Neurol. 2020 Dec 7. doi: 10.1002/acn3.51235. Online ahead of print.

Pages