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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model for Phospholamban R14del cardiomyopathy

Authors:
Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Onderwater YL, Chocron S, Polidoro Pontalti C, Vos MA, de Boer TP, van Veen TAB, Bakkers J
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.25.397422
Epub:
Not Epub
Abstract:
The heterozygous phospholamban (PLN) p.Arg14del (R14del) mutation is found in patients with dilated or arrhythmogenic...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.25.397422v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Onderwater YL, Chocron S, Polidoro Pontalti C, Vos MA, de Boer TP, van Veen TAB, Bakkers J. Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model for Phospholamban R14del cardiomyopathy. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.25.397422.

Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation

Authors:
Wang X, Liu L, Whisnant AW, Hennig T, Djakovic L, Haque N, Bach C, Sandri-Goldin RM, Erhard F, Friedel CC, Dölken L, Shi Y
Citation:
PLoS Genet. 2021 Mar 8;17(3):e1009263. doi: 10.1371/journal.pgen.1009263. PMID: 33684133; PMCID: PMC7971895.
Epub:
Not Epub
Abstract:
Eukaryotic gene expression is extensively regulated by cellular stress and pathogen infections. We have previously shown that...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7971895/
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Wang X, Liu L, Whisnant AW, Hennig T, Djakovic L, Haque N, Bach C, Sandri-Goldin RM, Erhard F, Friedel CC, Dölken L, Shi Y. Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation. PLoS Genet. 2021 Mar 8;17(3):e1009263. doi: 10.1371/journal.pgen.1009263. PMID: 33684133; PMCID: PMC7971895..

H2S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish

Authors:
Jiang W, Liu C, Deng M, Wang F, Ren X, Fan Y, Du J, Wang Y
Citation:
Stroke Vasc Neurol. 2020 Nov 27:svn-2020-000584. doi: 10.1136/svn-2020-000584. Online ahead of print
Epub:
Yes
Abstract:
Background: Hydrogen sulphide (H2S) is considered as the third member of the gasotransmitter family, along with nitric oxide (...
Link:
https://svn.bmj.com/content/early/2020/11/26/svn-2020-000584
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiang W, Liu C, Deng M, Wang F, Ren X, Fan Y, Du J, Wang Y. H2S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish. Stroke Vasc Neurol. 2020 Nov 27:svn-2020-000584. doi: 10.1136/svn-2020-000584. Online ahead of print.

Abnormal Vasculature Development in Zebrafish Embryos with Reduced Expression of Pantothenate Kinase 2 Gene

Authors:
Khatri D, Mignani L, Zizioli D, Ritelli M, Monti E, Finazzi D
Citation:
Bull Exp Biol Med. 2020 Nov 25. doi: 10.1007/s10517-020-05004-3. Online ahead of print
Epub:
Yes
Abstract:
Mutations in pank2 gene encoding pantothenate kinase 2 determine a pantothenate kinase-associated neurodegeneration, a rare...
Link:
https://link.springer.com/article/10.1007%2Fs10517-020-05004-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Khatri D, Mignani L, Zizioli D, Ritelli M, Monti E, Finazzi D. Abnormal Vasculature Development in Zebrafish Embryos with Reduced Expression of Pantothenate Kinase 2 Gene. Bull Exp Biol Med. 2020 Nov 25. doi: 10.1007/s10517-020-05004-3. Online ahead of print.

Loss of ITGB3 in Ovine Conceptuses Decreases Conceptus Expression of NOS3 and SPP1: Implications for the Developing Placental Vasculature†

Authors:
Frank JW, Steinhauser CB, Wang X, Burghardt RC, Bazer FW, Johnson GA
Citation:
Biol Reprod. 2020;[Epub ahead of print] doi:10.1093/biolre/ioaa212
Epub:
Yes
Abstract:
During the peri-implantation period of pregnancy in sheep there is an initial period of loose apposition of the elongating...
Link:
https://academic.oup.com/biolreprod/advance-article-abstract/doi/10.1093/biolre/ioaa212/5999900
Organism or Cell Type:
Ovis aries (sheep)
Citation Extract:
Frank JW, Steinhauser CB, Wang X, Burghardt RC, Bazer FW, Johnson GA. Loss of ITGB3 in Ovine Conceptuses Decreases Conceptus Expression of NOS3 and SPP1: Implications for the Developing Placental Vasculature†. Biol Reprod. 2020;[Epub ahead of print] doi:10.1093/biolre/ioaa212.

An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates

Authors:
Carroll SH, Trevino CM, Li EB, Kawasaki K, Myers N, Hallett SA, Alhazmi N, Cotney J, Carstens RP, Liao EC
Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.194498
Epub:
Yes
Abstract:
Irf6 and Esrp1 are important for palate development across vertebrates. In zebrafish, we found that irf6 regulates the...
Link:
https://dev.biologists.org/content/early/2020/11/23/dev.194498
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carroll SH, Trevino CM, Li EB, Kawasaki K, Myers N, Hallett SA, Alhazmi N, Cotney J, Carstens RP, Liao EC. An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development. 2020;[Epub ahead of print] doi:10.1242/dev.194498.

Coping with DNA Double-Strand Breaks via ATM Signaling Pathway in Bovine Oocytes

Authors:
Lili Wang L, Xu X, Teng M, Zhao G, Lei A
Citation:
Int J Molec Sci. 2020;21(23):8892. doi:10.3390/ijms21238892
Epub:
Not Epub
Abstract:
As a common injury almost all cells face, DNA damage in oocytes—especially double-strand breaks (DSBs), which occur naturally...
Link:
https://www.mdpi.com/1422-0067/21/23/8892/htm
Delivery Method:
microinjection
Organism or Cell Type:
Bos taurus (cattle) oocytes
Citation Extract:
Lili Wang L, Xu X, Teng M, Zhao G, Lei A. Coping with DNA Double-Strand Breaks via ATM Signaling Pathway in Bovine Oocytes. Int J Molec Sci. 2020;21(23):8892. doi:10.3390/ijms21238892.

In vivo, Ex Vivo, and In Vitro Approaches to Study Intermediate Filaments in the Eye Lens

Authors:
Jarrin M, Young L, Wu W, Girkin JM, Quinlan RA
Citation:
Methods Enzymol. 2016;568:581-611 Chapter 21 doi:10.1016/bs.mie.2015.09.010
Epub:
Not Epub
Abstract:
The role of the eye lens is to focus light into the retina. To perform this unique function, the ocular lens must be...
Link:
https://www.sciencedirect.com/science/article/pii/S0076687915005145
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jarrin M, Young L, Wu W, Girkin JM, Quinlan RA. In vivo, Ex Vivo, and In Vitro Approaches to Study Intermediate Filaments in the Eye Lens. Methods Enzymol. 2016;568:581-611 Chapter 21 doi:10.1016/bs.mie.2015.09.010.

SRP54 mutations induce Congenital Neutropenia via dominant-negative effects on XBP1 splicing

Authors:
Schürch C, Schaefer T, Müller JS, Hanns P, Arnone M, Dumlin A, Schärer J, Sinning I, Wild K, Skokowa J, Welte K, Carapito R, Bahram S, Konantz M, Lengerke C
Citation:
Blood (2021) 137 (10): 1340–1352. doi:10.1182/blood.2020008115
Epub:
Not Epub
Abstract:
Heterozygous de novo missense variants of SRP54 were recently identified in patients with congenital neutropenia (CN),...
Link:
https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2020008115/474249/SRP54-mutations-induce-Congenital-Neutropenia-via
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schürch C, Schaefer T, Müller JS, Hanns P, Arnone M, Dumlin A, Schärer J, Sinning I, Wild K, Skokowa J, Welte K, Carapito R, Bahram S, Konantz M, Lengerke C. SRP54 mutations induce Congenital Neutropenia via dominant-negative effects on XBP1 splicing. Blood (2021) 137 (10): 1340–1352. doi:10.1182/blood.2020008115.

Striatal astrocytes shape behavioral flexibility via regulation of the glutamate transporter EAAT2

Authors:
Boender AJ, Bontempi L, Nava L, Pelloux Y, Tonini R
Citation:
Biol Psychiatry. 2020;[Epub ahead of print] doi:10.1016/j.biopsych.2020.11.015
Epub:
Yes
Abstract:
Background: Striatal circuits must be modulated for behavioral flexibility – the ability to adapt to environmental changes....
Link:
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(20)32076-X/fulltext
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Boender AJ, Bontempi L, Nava L, Pelloux Y, Tonini R. Striatal astrocytes shape behavioral flexibility via regulation of the glutamate transporter EAAT2. Biol Psychiatry. 2020;[Epub ahead of print] doi:10.1016/j.biopsych.2020.11.015.

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