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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4

Authors:
Sanchez E, Laplace-Builhé B, Mau-Them FT, Richard E, Goldenberg A, Toler TL, Guignard T, Gatinois V, Vincent M, Blanchet C, Boland A, Bihoreau MT, Deleuze JF, Olaso R, Nephi W, Lüdecke HJ, Verheij JBGM, Moreau-Lenoir F, Denoyelle F, Rivière JB, Laplanche JL, Willing M, Captier G, Apparailly F, Wieczorek D, Collet C, Djouad F, Geneviève D
Citation:
Genet Med. 2019 Oct 24. doi: 10.1038/s41436-019-0669-9. [Epub ahead of print]
Epub:
Yes
Abstract:
PURPOSE: Treacher Collins syndrome (TCS) is a rare autosomal dominant mandibulofacial dysostosis, with a prevalence of 0.2-1/10...
Link:
https://www.nature.com/articles/s41436-019-0669-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez E, Laplace-Builhé B, Mau-Them FT, Richard E, Goldenberg A, Toler TL, Guignard T, Gatinois V, Vincent M, Blanchet C, Boland A, Bihoreau MT, Deleuze JF, Olaso R, Nephi W, Lüdecke HJ, Verheij JBGM, Moreau-Lenoir F, Denoyelle F, Rivière JB, Laplanche JL, Willing M, Captier G, Apparailly F, Wieczorek D, Collet C, Djouad F, Geneviève D. POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4. Genet Med. 2019 Oct 24. doi: 10.1038/s41436-019-0669-9. [Epub ahead of print].

Composition dependent phase separation underlies directional flux through the nucleolus

Authors:
Riback JA, Zhu L, Ferrolino MC, Tolbert M, Mitrea DM, Sanders DW, Wei M-T, Kriwacki RW, Brangwynne CP
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/809210
Epub:
Not Epub
Abstract:
Intracellular bodies such as nucleoli, Cajal bodies, and various signaling assemblies, represent membraneless organelles, or...
Link:
https://www.biorxiv.org/content/10.1101/809210v1
Citation Extract:
Riback JA, Zhu L, Ferrolino MC, Tolbert M, Mitrea DM, Sanders DW, Wei M-T, Kriwacki RW, Brangwynne CP. Composition dependent phase separation underlies directional flux through the nucleolus. bioRxiv. 2019;[preprint] doi:10.1101/809210.

Interleukin-6 signaling regulates hematopoietic stem cell emergence

Authors:
Tie R, Li H, Cai S, Liang Z, Shan W, Wang B, Tan Y, Zheng W, Huang H
Citation:
Exp Mol Med. 2019 Oct 24;51(10):124. doi: 10.1038/s12276-019-0320-5
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs) produce all lineages of mature blood cells for the lifetime of an organism. In vertebrates,...
Link:
https://www.nature.com/articles/s12276-019-0320-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tie R, Li H, Cai S, Liang Z, Shan W, Wang B, Tan Y, Zheng W, Huang H. Interleukin-6 signaling regulates hematopoietic stem cell emergence. Exp Mol Med. 2019 Oct 24;51(10):124. doi: 10.1038/s12276-019-0320-5.

Loss-of-spen disturbs cardiac conduction in zebrafish mediated by impaired connexin43 function

Authors:
Rattka M, Westphal S, Pott A, Kessler M, Weinmann K, Just S, Rottbauer W
Citation:
Eur Heart J, 2019;40(Supplement_1):ehz746.0023. doi:10.1093/eurheartj/ehz746.0023
Epub:
Not Epub
Abstract:
Genome-wide association studies identified SPLIT ENDS (SPEN) gene as an interesting candidate in the pathogenesis of heart...
Link:
https://academic.oup.com/eurheartj/article-abstract/40/Supplement_1/ehz746.0023/5595331
Organism or Cell Type:
zebrafish
Citation Extract:
Rattka M, Westphal S, Pott A, Kessler M, Weinmann K, Just S, Rottbauer W. Loss-of-spen disturbs cardiac conduction in zebrafish mediated by impaired connexin43 function. Eur Heart J, 2019;40(Supplement_1):ehz746.0023. doi:10.1093/eurheartj/ehz746.0023.

Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration

Authors:
Korotkova DD, Lyubetsky VA, Ivanova AS, Rubanov LI, Seliverstov AV, Zverkov OA, Martynova NY, Nesterenko AM, Tereshina MB, Peshkin L, Zaraisky AG
Citation:
Cell Rep. 2019 Oct 22;29(4):1027-1040.e6. doi: 10.1016/j.celrep.2019.09.038
Epub:
Not Epub
Abstract:
The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood...
Link:
https://www.sciencedirect.com/science/article/pii/S2211124719312264
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Korotkova DD, Lyubetsky VA, Ivanova AS, Rubanov LI, Seliverstov AV, Zverkov OA, Martynova NY, Nesterenko AM, Tereshina MB, Peshkin L, Zaraisky AG. Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration. Cell Rep. 2019 Oct 22;29(4):1027-1040.e6. doi: 10.1016/j.celrep.2019.09.038.

Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure

Authors:
Hashimoto H, Munro E
Citation:
Dev Cell. 2019 Oct 21;51(2):158-172.e4. doi: 10.1016/j.devcel.2019.10.001
Epub:
Not Epub
Abstract:
Embryos control force generation at tissue bound-aries, but how they do so remains poorly understood.Here we show how tissue-...
Link:
https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(19)30810-X
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (AKA C. intestinalis; ascidian)
Citation Extract:
Hashimoto H, Munro E. Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure. Dev Cell. 2019 Oct 21;51(2):158-172.e4. doi: 10.1016/j.devcel.2019.10.001.

Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia

Authors:
Wagner M, Osborn DPS, Gehweiler I, Nagel M, Ulmer U, Bakhtiari S, Amouri R, Boostani R, Hentati F, Hockley MM, Hölbling B, Schwarzmayr T, Karimiani EG, Kernstock C, Maroofian R, Müller-Felber W, Ozkan E, Padilla-Lopez S, Reich S, Reichbauer J, Darvish H, Shahmohammadibeni N, Tafakhori A, Vill K, Zuchner S, Kruer MC, Winkelmann J, Jamshidi Y, Schüle R
Citation:
Nat Commun. 2019 Oct 21;10(1):4790. doi: 10.1038/s41467-019-12620-9
Epub:
Not Epub
Abstract:
Alterations of Ca2+ homeostasis have been implicated in a wide range of neurodegenerative diseases. Ca2+ efflux from the...
Link:
https://www.nature.com/articles/s41467-019-12620-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wagner M, Osborn DPS, Gehweiler I, Nagel M, Ulmer U, Bakhtiari S, Amouri R, Boostani R, Hentati F, Hockley MM, Hölbling B, Schwarzmayr T, Karimiani EG, Kernstock C, Maroofian R, Müller-Felber W, Ozkan E, Padilla-Lopez S, Reich S, Reichbauer J, Darvish H, Shahmohammadibeni N, Tafakhori A, Vill K, Zuchner S, Kruer MC, Winkelmann J, Jamshidi Y, Schüle R. Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia. Nat Commun. 2019 Oct 21;10(1):4790. doi: 10.1038/s41467-019-12620-9.

The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis

Authors:
Cuenca A, Insinna C, Zhao H, John P, Weiss MA, Lu Q, Walia V, Specht S, Manivannan S, Stauffer J, Peden AA, Westlake CJ
Citation:
J Biol Chem. 2019 Oct 18;294(42):15418-15434. doi: 10.1074/jbc.RA119.008615. Epub 2019 Aug 29
Epub:
Not Epub
Abstract:
The primary cilium is a cellular sensor that detects light, chemicals, and movement and is important for morphogen and growth...
Link:
http://www.jbc.org/content/294/42/15418.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cuenca A, Insinna C, Zhao H, John P, Weiss MA, Lu Q, Walia V, Specht S, Manivannan S, Stauffer J, Peden AA, Westlake CJ. The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis. J Biol Chem. 2019 Oct 18;294(42):15418-15434. doi: 10.1074/jbc.RA119.008615. Epub 2019 Aug 29.

Brain aromatase modulates cardiac functions in embryonic zebrafish

Authors:
Ulhaq ZS
Citation:
Int J Vet Sci Med. 2019;7(1):31-4. doi:10.1080/23144599.2019.1675287
Epub:
Not Epub
Abstract:
Oestradiol (E2) is known as a female reproductive hormone with pleiotropic effects on the cardiovascular system. Local E2...
Link:
https://www.tandfonline.com/doi/full/10.1080/23144599.2019.1675287
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ulhaq ZS. Brain aromatase modulates cardiac functions in embryonic zebrafish. Int J Vet Sci Med. 2019;7(1):31-4. doi:10.1080/23144599.2019.1675287.

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Authors:
Higashikuse Y, Mittal N, Arimura T, Yoon SH, Oda M, Enomoto H, Kaneda R, Fumiyuki Hattori F, Suzuki T, Kawakami A, Gasch A, Furukawa T, Labeit S, Fukuda K, Kimura A, Makino S
Citation:
Dis Model Mech. 2019;[Epub] doi:10.1242/dmm.041103
Epub:
Yes
Abstract:
Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene...
Link:
https://dmm.biologists.org/content/early/2019/10/17/dmm.041103
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Higashikuse Y, Mittal N, Arimura T, Yoon SH, Oda M, Enomoto H, Kaneda R, Fumiyuki Hattori F, Suzuki T, Kawakami A, Gasch A, Furukawa T, Labeit S, Fukuda K, Kimura A, Makino S. Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients. Dis Model Mech. 2019;[Epub] doi:10.1242/dmm.041103.

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