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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish

Authors:
Soman S, Keatinge M, Moein M, Da Costa M, Mortiboys H, Skupin A, Sugunan S, Bazala M, Kuznicki J, Bandmann O
Citation:
Eur J Neurosci. 2017 Feb;45(4):528-535. doi: 10.1111/ejn.13473. Epub 2016 Dec 28
Epub:
Not Epub
Abstract:
Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/ejn.13473
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Soman S, Keatinge M, Moein M, Da Costa M, Mortiboys H, Skupin A, Sugunan S, Bazala M, Kuznicki J, Bandmann O. Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish. Eur J Neurosci. 2017 Feb;45(4):528-535. doi: 10.1111/ejn.13473. Epub 2016 Dec 28.

CTENO64 Is Required for Coordinated Paddling of Ciliary Comb Plate in Ctenophores

Authors:
Jokura K, Shibata D, Yamaguchi K, Shiba K, Makino Y, Shigenobu S, Inaba K
Citation:
Curr Biol. 2019;29:[Epub in press] doi:10.1016/j.cub.2019.08.059
Epub:
Yes
Abstract:
Ctenophores, or comb jellies, are one of the earliestbranching basal metazoan groups, whose phyloge-netic position continues to...
Link:
https://www.cell.com/current-biology/fulltext/S0960-9822(19)31109-1
Delivery Method:
microinjection
Organism or Cell Type:
Bolinopsis mikado (Ctenophore, comb jelly)
Citation Extract:
Jokura K, Shibata D, Yamaguchi K, Shiba K, Makino Y, Shigenobu S, Inaba K. CTENO64 Is Required for Coordinated Paddling of Ciliary Comb Plate in Ctenophores. Curr Biol. 2019;29:[Epub in press] doi:10.1016/j.cub.2019.08.059.

Systematic Approach to Developing Splice Modulating Antisense Oligonucleotides

Authors:
Aung-Htut MT, McIntosh CS, Ham KA, Pitout IL, Flynn LL, Greer K, Fletcher S, Wilton SD
Citation:
Int J Mol Sci. 2019;20(20):5030. doi:10.3390/ijms20205030
Epub:
Not Epub
Abstract:
The process of pre-mRNA splicing is a common and fundamental step in the expression of most human genes. Alternative splicing,...
Link:
https://www.mdpi.com/1422-0067/20/20/5030/htm
Citation Extract:
Aung-Htut MT, McIntosh CS, Ham KA, Pitout IL, Flynn LL, Greer K, Fletcher S, Wilton SD. Systematic Approach to Developing Splice Modulating Antisense Oligonucleotides. Int J Mol Sci. 2019;20(20):5030. doi:10.3390/ijms20205030.

Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish

Authors:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Ramachandran R
Citation:
Life Sci Alliance. 2019 Oct 8;2(5). pii: e201900548. doi: 10.26508/lsa.201900548. Print 2019 Oct
Epub:
Not Epub
Abstract:
Octamer-binding transcription factor 4 (Oct4, also known as Pou5F3) is an essential pluripotency-inducing factor, governing a...
Link:
https://www.life-science-alliance.org/content/2/5/e201900548
Delivery Method:
ocular injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Ramachandran R. Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish. Life Sci Alliance. 2019 Oct 8;2(5). pii: e201900548. doi: 10.26508/lsa.201900548. Print 2019 Oct.

Spliceosomal disruption of the non-canonical BAF complex in cancer

Authors:
Inoue D, Chew G-L, Liu B, Michel BC, Pangallo J, D’Avino AR, Hitchman T, North K, Lee SC-W, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK
Citation:
Nature. 2019;[Epub ahead of print] doi:10.1038/s41586-019-1646-9
Epub:
Yes
Abstract:
SF3B1 is the most commonly mutated RNA splicing factor in cancer1–4, but the mechanisms by which SF3B1 mutations promote...
Link:
https://www.nature.com/articles/s41586-019-1646-9
Delivery Method:
intratumoral injection
Organism or Cell Type:
cell culture: MEL202 cells (SF3B1R625G) xenografted in mice
Citation Extract:
Inoue D, Chew G-L, Liu B, Michel BC, Pangallo J, D’Avino AR, Hitchman T, North K, Lee SC-W, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK. Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature. 2019;[Epub ahead of print] doi:10.1038/s41586-019-1646-9.

Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility

Authors:
Pritchard HAT,Griffin CS, Yamasaki E, Thakore P, Lane C, Greenstein AS, Earley S
Citation:
PNAS USA. 2019 Oct 22;116(43):21874-21881. doi: 10.1073/pnas.1911304116. Epub 2019 Oct 7
Epub:
Not Epub
Abstract:
Junctophilin proteins maintain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane in...
Link:
https://www.pnas.org/content/early/2019/10/02/1911304116
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: dissected cerebral arteries (vascular smooth muscle)
Citation Extract:
Pritchard HAT,Griffin CS, Yamasaki E, Thakore P, Lane C, Greenstein AS, Earley S. Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility. PNAS USA. 2019 Oct 22;116(43):21874-21881. doi: 10.1073/pnas.1911304116. Epub 2019 Oct 7.

Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish

Authors:
Mano H, Asaoka Y, Kojima D, Fukada Y
Citation:
Commun Biol. 2019;2(1):364 doi:10.1038/s42003-019-0613-1
Epub:
Not Epub
Abstract:
The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we...
Link:
https://www.nature.com/articles/s42003-019-0613-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mano H, Asaoka Y, Kojima D, Fukada Y. Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish. Commun Biol. 2019;2(1):364 doi:10.1038/s42003-019-0613-1.

p63 is a cereblon substrate involved in thalidomide teratogenicity

Authors:
Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H
Citation:
Nat Chem Biol. 2019;[Epub ahead of print] doi:10.1038/s41589-019-0366-7
Epub:
Yes
Abstract:
Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic...
Link:
https://www.nature.com/articles/s41589-019-0366-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H. p63 is a cereblon substrate involved in thalidomide teratogenicity. Nat Chem Biol. 2019;[Epub ahead of print] doi:10.1038/s41589-019-0366-7.

Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes

Authors:
Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A
Citation:
Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31825-X. doi: 10.1016/j.bbrc.2019.09.095. [Epub ahead of print]
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a devastating muscle disorder caused by frameshift mutations in the DMD gene. DMD involves...
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X1931825X
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: iPSC-derived cardiomyocytes
Citation Extract:
Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A. Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31825-X. doi: 10.1016/j.bbrc.2019.09.095. [Epub ahead of print].

Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics

Authors:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/791780
Epub:
Not Epub
Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the...
Link:
https://www.biorxiv.org/content/10.1101/791780v1
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. bioRxiv. 2019;[preprint] doi:10.1101/791780 .

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