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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12511 scientific papers returned from the database with the search filters currently being used below.
There are 12511 scientific papers returned from the database with the search filters currently being used below.
A Missense Variant in PDK1 Associated with Severe Neurodevelopmental Delay and Epilepsy
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Citation:
Biomedicines. 2022;10(12):3171. doi:10.3390/biomedicines10123171 Epub:
Not Epub Abstract:
The pyruvate dehydrogenase complex (PDC) is responsible for the conversion of pyruvate into acetyl-CoA, which is used for... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vaz R, Wincent J, Elfissi N, Rosengren Forsblad K, Pettersson M, Naess K, Wedell A, Wredenberg A, Lindstrand A, Ygberg S. A Missense Variant in PDK1 Associated with Severe Neurodevelopmental Delay and Epilepsy. Biomedicines. 2022;10(12):3171. doi:10.3390/biomedicines10123171 . |
CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII
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Citation:
Blood Adv. 2023 Mar 14;7(5):697-711. doi: 10.1182/bloodadvances.2022009014. PMID: 36477543; PMCID: PMC9984962 Epub:
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Emerging gene therapy clinical trials test the correction of hemophilia A (HA) by replacing factor VIII (FVIII) in autologous... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Elnaggar M, Al-Mohannadi A, Hasan W, Abdelrahman D, Al-Kubaisi MJ, Pavlovski I, Gentilcore G, Sathappan A, Kizhakayil D, Ali AI, Mohan S, Olagunju D, Cugno C, Grivel JC, Borsotti C, Follenzi A, Da'as SI, Deola S. CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII. Blood Adv. 2023 Mar 14;7(5):697-711. doi: 10.1182/bloodadvances.2022009014. PMID: 36477543; PMCID: PMC9984962. |
Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration
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Citation:
Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211690119. doi: 10.1073/pnas.2211690119. Epub 2022 Dec 5 Epub:
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In the zebrafish retina, Müller glia (MG) can regenerate retinal neurons lost to injury or disease. Even though zebrafish MG... Delivery Method:
injection Organism or Cell Type:
zebrafish Citation Extract: Mitra S, Devi S, Lee M-S, Goldman D. Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211690119. doi: 10.1073/pnas.2211690119. Epub 2022 Dec 5. |
Human SLFN5 and its Xenopus Laevis ortholog regulate entry into mitosis and oocyte meiotic resumption
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Citation:
Cell Death Discov. 2022;8(1):484. doi:10.1038/s41420-022-01274-0 Epub:
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The Schlafen gene family was first described in mice as a regulator of thymocyte development. Further studies showed... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Vit G, Hirth A, Neugebauer N, Kraft BN, Sigismondo G, Cazzola A, Tessmer C, Duro J, Krijgsveld J, Hofmann I, Berger M, Klüter H, Niehrs C, Nilsson J, Krämer A. Human SLFN5 and its Xenopus Laevis ortholog regulate entry into mitosis and oocyte meiotic resumption. Cell Death Discov. 2022;8(1):484. doi:10.1038/s41420-022-01274-0. |
Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition
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Citation:
Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2212879119. doi: 10.1073/pnas.2212879119. Epub 2022 Dec 12 Epub:
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Epithelial-to-mesenchymal transition (EMT) is a dramatic change in cellular physiology during development and metastasis, which... Delivery Method:
electroporation Organism or Cell Type:
Gallus gallus (chick) Citation Extract: Piacentino ML, Hutchins EJ, Andrews CJ, Bronner ME. Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2212879119. doi: 10.1073/pnas.2212879119. Epub 2022 Dec 12. |
Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia
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Citation:
Genes Genomics. 2022 Dec 12. doi: 10.1007/s13258-022-01350-w. Online ahead of print Epub:
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Background: Motile cilia in a vertebrate are important to sustaining activities of life. Fluid flow on the apical surface of... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Kwon KY, Jeong H, Jang DG, Kwon T, Park TJ. Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia. Genes Genomics. 2022 Dec 12. doi: 10.1007/s13258-022-01350-w. Online ahead of print. |
Loxhd1b inhibits the hair cell development in zebrafish: Possible relation to the BDNF/TrkB/ERK pathway
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Citation:
Front Cell Neurosci. 2022 Nov 24;16:1065309. doi: 10.3389/fncel.2022.1065309. eCollection 2022 Epub:
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Background: Mutations in lipoxygenase homology domain 1 (LOXHD1) cause autosomal recessive inheritance, leading to high-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Liu J, Zhang X, Zhang Q, Wang R, Ma J, Bai X, Wang D. Loxhd1b inhibits the hair cell development in zebrafish: Possible relation to the BDNF/TrkB/ERK pathway. Front Cell Neurosci. 2022 Nov 24;16:1065309. doi: 10.3389/fncel.2022.1065309. eCollection 2022. |
ftr82 is necessary for hair cell morphogenesis and auditory function during zebrafish development
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Citation:
J Genet Genomics. 2022 Dec 1:S1673-8527(22)00252-1. doi: 10.1016/j.jgg.2022.11.008. Online ahead of print Epub:
Yes Abstract:
Damages of sensory hair cells (HCs) are mainly responsible for sensorineural hearing loss, while the pathological mechanism... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yin G, Qian F, Yao J, Wang Z, Wang X, Liu D, Wang C. ftr82 is necessary for hair cell morphogenesis and auditory function during zebrafish development. J Genet Genomics. 2022 Dec 1:S1673-8527(22)00252-1. doi: 10.1016/j.jgg.2022.11.008. Online ahead of print. |
PPMOs: A Case Study for Cell-Penetrating Peptide Application
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Citation:
In Cell-Penetrating Peptides (eds M. Oba and Y. Demizu). 2023:ch 15. doi:10.1002/9783527835997.ch15 Epub:
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The current state of the art for in vivo antisense morpholino technology is peptide-conjugated phosphorodiamidate morpholino... Delivery Method:
peptide-linked Citation Extract: Bittner S, Moulton ZX, Moulton HM. PPMOs: A Case Study for Cell-Penetrating Peptide Application. In Cell-Penetrating Peptides (eds M. Oba and Y. Demizu). 2023:ch 15. doi:10.1002/9783527835997.ch15. |
LOF variants identifying candidate genes of laterality defects patients with congenital heart disease
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Citation:
PLoS Genet. 2022;18(12):e1010530. doi:10.1371/journal.pgen.1010530 Epub:
Not Epub Abstract:
Defects in laterality pattern can result in abnormal positioning of the internal organs during the early stages of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Liu S, Wei W, Wang P, Liu C, Jiang X, Li T, Li F, Wu Y, Chen S, Sun K, Xu R. LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. PLoS Genet. 2022;18(12):e1010530. doi:10.1371/journal.pgen.1010530. |