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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12511 scientific papers returned from the database with the search filters currently being used below.

Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates

Authors:
Faustini G, Longhena F, Muscò A, Bono F, Parrella E, La Via L, Barbon A, Pizzi M, Onofri F, Benfenati F, Missale C, Memo M, Zizioli D, Bellucci A
Citation:
Cells. 2022; 11(23):3902. doi:10.3390/cells11233902
Epub:
Not Epub
Abstract:
.Attention deficit and hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by alterations in the...
Link:
https://www.mdpi.com/2073-4409/11/23/3902
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Faustini G, Longhena F, Muscò A, Bono F, Parrella E, La Via L, Barbon A, Pizzi M, Onofri F, Benfenati F, Missale C, Memo M, Zizioli D, Bellucci A. Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates. Cells. 2022; 11(23):3902. doi:10.3390/cells11233902.

Viral-induced alternative splicing of host genes promotes influenza replication

Authors:
Thompson MG, Dittmar M, Mallory MJ, Bhat P, Ferretti MB, Fontoura BM, Cherry S, Lynch KW
Citation:
Elife. 2020 Dec 3;9:e55500. doi: 10.7554/eLife.55500
Epub:
Not Epub
Abstract:
Viral infection induces the expression of numerous host genes that impact the outcome of infection. Here, we show that...
Link:
https://elifesciences.org/articles/55500
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: A549
Citation Extract:
Thompson MG, Dittmar M, Mallory MJ, Bhat P, Ferretti MB, Fontoura BM, Cherry S, Lynch KW. Viral-induced alternative splicing of host genes promotes influenza replication. Elife. 2020 Dec 3;9:e55500. doi: 10.7554/eLife.55500.

Transposable elements drive the evolution of metazoan zinc finger genes

Authors:
Wells JN, Chang N-C, McCormick J, Coleman C, Ramos N, Jin B, Feschotte C
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.29.518450
Epub:
Not Epub
Abstract:
Cys2-His2 Zinc finger genes (ZNFs) form the largest family of transcription factors in metazoans. ZNF evolution is highly...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.29.518450v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wells JN, Chang N-C, McCormick J, Coleman C, Ramos N, Jin B, Feschotte C. Transposable elements drive the evolution of metazoan zinc finger genes. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.29.518450.

Parental mutations influence wild-type offspring via transcriptional adaptation

Authors:
Jiang Z, El-Brolosy MA, Serobyan V, Welker JM, Retzer N, Dooley CM, Jakutis G, Juan T, Fukuda N, Maischein HM, Balciunas D, Stainier DYR
Citation:
Sci Adv. 2022 Nov 25;8(47):eabj2029. doi: 10.1126/sciadv.abj2029. Epub 2022 Nov 25
Epub:
Not Epub
Abstract:
Transgenerational epigenetic inheritance (TEI) is mostly discussed in the context of physiological or environmental factors....
Link:
https://www.science.org/doi/10.1126/sciadv.abj2029
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiang Z, El-Brolosy MA, Serobyan V, Welker JM, Retzer N, Dooley CM, Jakutis G, Juan T, Fukuda N, Maischein HM, Balciunas D, Stainier DYR. Parental mutations influence wild-type offspring via transcriptional adaptation. Sci Adv. 2022 Nov 25;8(47):eabj2029. doi: 10.1126/sciadv.abj2029. Epub 2022 Nov 25.

Top2a promotes the development of social behavior via PRC2 and H3K27me3

Authors:
Geng Y, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, Nath AK, Yeh JJ, Drummond IA, Bortolato M, Peterson RT
Citation:
Sci Adv. 2022 Nov 25;8(47):eabm7069. doi: 10.1126/sciadv.abm7069. Epub 2022 Nov 23
Epub:
Not Epub
Abstract:
Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic...
Link:
https://www.science.org/doi/pdf/10.1126/sciadv.abm7069
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geng Y, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, Nath AK, Yeh JJ, Drummond IA, Bortolato M, Peterson RT. Top2a promotes the development of social behavior via PRC2 and H3K27me3. Sci Adv. 2022 Nov 25;8(47):eabm7069. doi: 10.1126/sciadv.abm7069. Epub 2022 Nov 23.

Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11

Authors:
Zadra I, Jimenez-Delgado S, Anglada-Girotto M, Segura-Morales C, Compton ZJ, Janke C, Serrano L, Ruprecht V, Vernos I
Citation:
Nat Commun. 2022 Nov 21;13(1):7147. doi: 10.1038/s41467-022-34909-y
Epub:
Not Epub
Abstract:
Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show...
Link:
https://www.nature.com/articles/s41467-022-34909-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zadra I, Jimenez-Delgado S, Anglada-Girotto M, Segura-Morales C, Compton ZJ, Janke C, Serrano L, Ruprecht V, Vernos I. Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. Nat Commun. 2022 Nov 21;13(1):7147. doi: 10.1038/s41467-022-34909-y.

Microenvironmental Snail1 is a driver of immunosuppression in melanoma

Authors:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.23.517623
Epub:
Not Epub
Abstract:
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.23.517623v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B. Microenvironmental Snail1 is a driver of immunosuppression in melanoma. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.23.517623 .

N-Fluoroalkylated Morpholinos - a New Class of Nucleoside Analogues

Authors:
Debreczeni N, Hotzi J, Bege M, Lovas M, Mező E, Bereczki I, Herczegh P, Kiss L, Borbás A
Citation:
Chemistry. 2022 Nov 27. doi: 10.1002/chem.202203248. Online ahead of print. PMID: 36437234
Epub:
Not Epub
Abstract:
The first concise and efficient synthesis of some fluorine-containing morpholino nucleosides analogs has been developed. One...
Link:
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202203248
Citation Extract:
Debreczeni N, Hotzi J, Bege M, Lovas M, Mező E, Bereczki I, Herczegh P, Kiss L, Borbás A. N-Fluoroalkylated Morpholinos - a New Class of Nucleoside Analogues. Chemistry. 2022 Nov 27. doi: 10.1002/chem.202203248. Online ahead of print. PMID: 36437234 .

Use of vivo-morpholinos for gene knockdown in the postnatal shark retina

Authors:
Rodríguez-Arrizabalaga M, Hernández-Núñez I, Candal E, Barreiro-Iglesias A
Citation:
Exp Eye Res. 2022 Nov 24:109333. doi: 10.1016/j.exer.2022.109333. Online ahead of print
Epub:
Yes
Abstract:
Work in the catshark Scyliorhinus canicula has shown that the evolutionary origin of postnatal neurogenesis in vertebrates is...
Link:
https://www.sciencedirect.com/science/article/pii/S0014483522004146
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Scyliorhinus canicula (catshark)
Citation Extract:
Rodríguez-Arrizabalaga M, Hernández-Núñez I, Candal E, Barreiro-Iglesias A. Use of vivo-morpholinos for gene knockdown in the postnatal shark retina. Exp Eye Res. 2022 Nov 24:109333. doi: 10.1016/j.exer.2022.109333. Online ahead of print.

Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis

Authors:
Meadows V, Marakovits C, Ekser B, Kundu D, Zhou T, Kyritsi K, Pham L, Chen L, Kennedy L, Ceci L, Wu N, Carpino G, Zhang W, Isidan A, Meyer A, Owen T, Gaudio E, Onori P, Alpini GD, Francis H
Citation:
Am J Physiol Gastrointest Liver Physiol. 2022 Nov 21. doi: 10.1152/ajpgi.00112.2022. Online ahead of print
Epub:
Yes
Abstract:
Background: Primary Sclerosing Cholangitis (PSC) is characterized by increased ductular reaction (DR), liver fibrosis, hepatic...
Link:
https://journals.physiology.org/doi/abs/10.1152/ajpgi.00112.2022
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Meadows V, Marakovits C, Ekser B, Kundu D, Zhou T, Kyritsi K, Pham L, Chen L, Kennedy L, Ceci L, Wu N, Carpino G, Zhang W, Isidan A, Meyer A, Owen T, Gaudio E, Onori P, Alpini GD, Francis H. Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis. Am J Physiol Gastrointest Liver Physiol. 2022 Nov 21. doi: 10.1152/ajpgi.00112.2022. Online ahead of print.

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