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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids

Authors:
Waldrip ZJ, Burdine L, Peterson EC, Rainwater RR, Min Y, Burdine MS
Citation:
iScience. 2025 Aug 6;28(9):113303. doi: 10.1016/j.isci.2025.113303. PMID: 40894886; PMCID: PMC12390945
Epub:
Not Epub
Abstract:
There is untapped potential for medical breakthroughs using engineered microbes to treat conditions such as those of the...
Link:
https://www.cell.com/ajhg/fulltext/S0002-9297(25)00179-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Waldrip ZJ, Burdine L, Peterson EC, Rainwater RR, Min Y, Burdine MS. A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids. iScience. 2025 Aug 6;28(9):113303. doi: 10.1016/j.isci.2025.113303. PMID: 40894886; PMCID: PMC12390945.

A 3D genome compendium of breast cancer progression

Authors:
den Brand T, Collier MD, Flach KD, Gregoricchio S, Mayayo-Peralta I, Dauyey Z, Schuurman K, Teunissen H, Zwart W, de Wit E
Citation:
iScience (2025), doi: https://doi.org/10.1016/j.isci.2025.113268
Epub:
Not Epub
Abstract:
During cancer development and progression massive alterations in gene expression are observed. Gene regulation occurs within...
Link:
https://www.cell.com/iscience/pdf/S2589-0042(25)01529-9.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
den Brand T, Collier MD, Flach KD, Gregoricchio S, Mayayo-Peralta I, Dauyey Z, Schuurman K, Teunissen H, Zwart W, de Wit E. A 3D genome compendium of breast cancer progression. iScience (2025), doi: https://doi.org/10.1016/j.isci.2025.113268.

Novel autosomal dominant syndromic hearing loss caused by COL4A2 -related basement membrane dysfunction of cochlear capillaries and microcirculation disturbance

Authors:
Yang J, Ma Y, Gao X, Qiu S, Li X, Zhao W, Chen Y, Dong G, Lin R, Wei G, Nie H, Feng H, Gu X, Gao B, Dai P, Yuan Y
Citation:
Chin Med J (Engl). 2025 Aug 5;138(15):1888-1890. doi: 10.1097/CM9.0000000000003600. Epub 2025 Jul 9. PMID: 40629513; PMCID: PMC12321472
Epub:
Not Epub
Link:
https://journals.lww.com/cmj/fulltext/2025/08050/novel_autosomal_dominant_syndromic_hearing_loss.13.aspx
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang J, Ma Y, Gao X, Qiu S, Li X, Zhao W, Chen Y, Dong G, Lin R, Wei G, Nie H, Feng H, Gu X, Gao B, Dai P, Yuan Y. Novel autosomal dominant syndromic hearing loss caused by COL4A2 -related basement membrane dysfunction of cochlear capillaries and microcirculation disturbance. Chin Med J (Engl). 2025 Aug 5;138(15):1888-1890. doi: 10.1097/CM9.0000000000003600. Epub 2025 Jul 9. PMID: 40629513; PMCID: PMC12321472.

circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease

Authors:
Fu R, Wang C, Xu Z, Zhai J, Zhao Y, Liu X, Zhou Y, Gu P, Pan W, Wang Y, Cai W
Citation:
Pediatr Res. 2025 Aug 1. doi: 10.1038/s41390-025-04245-0. Epub ahead of print. PMID: 40750918
Epub:
Not Epub
Abstract:
Background: Circular RNAs (circRNAs) are implicated in Hirschsprung's disease (HSCR), a genetic disorder caused by...
Link:
https://www.nature.com/articles/s41390-025-04245-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fu R, Wang C, Xu Z, Zhai J, Zhao Y, Liu X, Zhou Y, Gu P, Pan W, Wang Y, Cai W. circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease. Pediatr Res. 2025 Aug 1. doi: 10.1038/s41390-025-04245-0. Epub ahead of print. PMID: 40750918.

SRC kinase isoforms regulate mRNA splicing during neural development

Authors:
Pizzey AR, West LC, Elberfeld SJ, Lewis PA, Walker H, Cowell L, Newling K, Dowle A, Evans GJO, Isaacs HV
Citation:
J Neurosci. 2025 Aug 1:e1705242025. doi: 10.1523/JNEUROSCI.1705-24.2025. Epub ahead of print. PMID: 40750357
Epub:
Not Epub
Abstract:
Alternative mRNA splicing generates transcriptomic diversity to direct tissue-specific functions. There is a high level of...
Link:
https://www.jneurosci.org/content/early/2025/07/31/JNEUROSCI.1705-24.2025.long
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Pizzey AR, West LC, Elberfeld SJ, Lewis PA, Walker H, Cowell L, Newling K, Dowle A, Evans GJO, Isaacs HV. SRC kinase isoforms regulate mRNA splicing during neural development. J Neurosci. 2025 Aug 1:e1705242025. doi: 10.1523/JNEUROSCI.1705-24.2025. Epub ahead of print. PMID: 40750357.

TMBIM4 affects left-right patterning via pluripotency exit during gastrulation

Authors:
Diab NS, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha MK
Citation:
Dev Biol. 2025 Jul 29:S0012-1606(25)00209-X. doi: 10.1016/j.ydbio.2025.07.018. Epub ahead of print. PMID: 40744297
Epub:
Not Epub
Abstract:
Congenital heart disease (CHD) is the most prevalent congenital defect, but its underlying genetic and developmental mechanisms...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S001216062500209X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Diab NS, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha MK. TMBIM4 affects left-right patterning via pluripotency exit during gastrulation. Dev Biol. 2025 Jul 29:S0012-1606(25)00209-X. doi: 10.1016/j.ydbio.2025.07.018. Epub ahead of print. PMID: 40744297.

Biallelic MED29 variants cause pontocerebellar hypoplasia with cataracts

Authors:
Arkush L, van Woerden GM, Ziv L, Marek-Yagel D, Fonseca R, Brevé E, Barel O, Shalva N, Veber A, Anikster Y, Ben-Ami Raichman D, Musallam B, Marcu S, Nissenkorn A, Mandel H, Kushner SA, Ben Zeev B, Heimer G
Citation:
Eur J Hum Genet. 2025 Jul 31. doi: 10.1038/s41431-025-01918-6. Epub ahead of print. PMID: 40745490
Epub:
Not Epub
Abstract:
Pontocerebellar hypoplasia (PCH) represents a group of disorders characterized by cerebellum and pons hypoplasia, variable...
Link:
https://www.nature.com/articles/s41431-025-01918-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arkush L, van Woerden GM, Ziv L, Marek-Yagel D, Fonseca R, Brevé E, Barel O, Shalva N, Veber A, Anikster Y, Ben-Ami Raichman D, Musallam B, Marcu S, Nissenkorn A, Mandel H, Kushner SA, Ben Zeev B, Heimer G. Biallelic MED29 variants cause pontocerebellar hypoplasia with cataracts. Eur J Hum Genet. 2025 Jul 31. doi: 10.1038/s41431-025-01918-6. Epub ahead of print. PMID: 40745490.

Targeting GLP-1 Signaling Ameliorates Cystogenesis in a Zebrafish Model of Nephronophthisis

Authors:
Eckert P, Nöller M, Müller M, Haas R, Ruf J, Franz H, Moos K, Yu, J-a, Zhao D, Xie W, Boerries M, Walz G, Yakulov TA
Citation:
International Journal of Molecular Sciences. 2025; 26(15):7366. https://doi.org/10.3390/ijms26157366
Epub:
Not Epub
Abstract:
Nephronophthisis (NPH) is the leading genetic cause of end-stage renal disease in children and young adults, but no effective...
Link:
https://www.mdpi.com/1422-0067/26/15/7366
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Eckert P, Nöller M, Müller M, Haas R, Ruf J, Franz H, Moos K, Yu, J-a, Zhao D, Xie W, Boerries M, Walz G, Yakulov TA. Targeting GLP-1 Signaling Ameliorates Cystogenesis in a Zebrafish Model of Nephronophthisis. International Journal of Molecular Sciences. 2025; 26(15):7366. https://doi.org/10.3390/ijms26157366.

Formation control between leader and migratory follower tissues allows coordinated growth

Authors:
Kawanishi T, Sushida T, Tsai TY, Takeda H, Megason SG
Citation:
Sci Adv. 2025 Aug;11(31):eads2310. doi: 10.1126/sciadv.ads2310. Epub 2025 Jul 30. PMID: 40737421; PMCID: PMC12309693
Epub:
Not Epub
Abstract:
Coordinated growth of multiple tissues is fundamental to shaping our body, but the underlying mechanisms remain underexplored....
Link:
https://www.science.org/doi/10.1126/sciadv.ads2310
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kawanishi T, Sushida T, Tsai TY, Takeda H, Megason SG. Formation control between leader and migratory follower tissues allows coordinated growth. Sci Adv. 2025 Aug;11(31):eads2310. doi: 10.1126/sciadv.ads2310. Epub 2025 Jul 30. PMID: 40737421; PMCID: PMC12309693.

Self-Assembling Multi-Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Authors:
Li S, Li J, Faruque HA, Shami P, Knoechel B, Lohr J, Sborov D, Yang J, Kopeček J
Citation:
Adv Healthc Mater. 2025 Aug 1:e02156. doi: 10.1002/adhm.202502156. Epub ahead of print. PMID: 40747784
Epub:
Not Epub
Abstract:
Bispecific T-cell engagers show promise in treating multiple myeloma (MM), but challenges remain in adaptability and targeting...
Link:
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502156
Delivery Method:
Fab-linked; mice: intravenous (i.v.) injection
Organism or Cell Type:
Multiple myeloma cells (MM.1S, MM.1R, RPMI-8226, ANBL-6, and U266), human PBMCs, primary T cells; mice: NRG (NOD-Rag1−/−IL2Rγnull)
Citation Extract:
Li S, Li J, Faruque HA, Shami P, Knoechel B, Lohr J, Sborov D, Yang J, Kopeček J. Self-Assembling Multi-Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma. Adv Healthc Mater. 2025 Aug 1:e02156. doi: 10.1002/adhm.202502156. Epub ahead of print. PMID: 40747784.

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