You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia

Authors:
Yeo HR, Shin MY, Kim J, Park SJ
Citation:
Microbiologyopen. 2025 Aug;14(4):e70038. doi: 10.1002/mbo3.70038. PMID: 40734239; PMCID: PMC12307541
Epub:
Not Epub
Abstract:
Centrins, Ca2+-binding proteins conserved in eukaryotes, are the key components of the microtubule-organizing center. Giardia...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mbo3.70038
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Yeo HR, Shin MY, Kim J, Park SJ. Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia. Microbiologyopen. 2025 Aug;14(4):e70038. doi: 10.1002/mbo3.70038. PMID: 40734239; PMCID: PMC12307541.

FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A

Authors:
Kastens G, Berger-Santangelo H, Gerstner S, Ufartes R, Mischak M, Borchers A, Pauli S
Citation:
Hum Genet. 2025 Jul 14. doi: 10.1007/s00439-025-02760-y. Epub ahead of print. PMID: 40658195
Epub:
Not Epub
Abstract:
FBRSL1-associated syndrome is a rare congenital malformation and intellectual disability syndrome caused by heterozygous...
Link:
https://link.springer.com/article/10.1007/s00439-025-02760-y
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kastens G, Berger-Santangelo H, Gerstner S, Ufartes R, Mischak M, Borchers A, Pauli S. FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A. Hum Genet. 2025 Jul 14. doi: 10.1007/s00439-025-02760-y. Epub ahead of print. PMID: 40658195.

Morpholino-Mediated Exon Inclusion for Spinal Muscular Atrophy (SMA)

Authors:
Zhou H, Muntoni F
Citation:
Methods Mol Biol. 2025;2964:433-444. doi: 10.1007/978-1-0716-4730-1_28. PMID: 40720035
Epub:
Not Epub
Abstract:
The application of antisense oligonucleotides (AONs) to modify pre-messenger RNA splicing has great potential for treating...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_28
Organism or Cell Type:
SMA mice
Citation Extract:
Zhou H, Muntoni F. Morpholino-Mediated Exon Inclusion for Spinal Muscular Atrophy (SMA). Methods Mol Biol. 2025;2964:433-444. doi: 10.1007/978-1-0716-4730-1_28. PMID: 40720035.

Systemic Injection of Antisense Oligos into Spinal Muscular Atrophy (SMA) Mice and Evaluation

Authors:
Aslesh T, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2025;2964:421-431. doi: 10.1007/978-1-0716-4730-1_27. PMID: 40720034
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is the most common genetic cause of infantile death caused by mutations in the SMN1 gene....
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_27
Delivery Method:
intracerebroventricular (i.c.v.) injection
Organism or Cell Type:
SMA mice
Citation Extract:
Aslesh T, Maruyama R, Yokota T. Systemic Injection of Antisense Oligos into Spinal Muscular Atrophy (SMA) Mice and Evaluation. Methods Mol Biol. 2025;2964:421-431. doi: 10.1007/978-1-0716-4730-1_27. PMID: 40720034.

Systemic Injection of Peptide-PMOs into Humanized DMD Mice and Detection by RT-PCR and ELISA

Authors:
Melo D, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2025;2964:231-242. doi: 10.1007/978-1-0716-4730-1_15. PMID: 40720022
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder due to the lack of dystrophin production. The disease is...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_15
Delivery Method:
peptide-linked; retro-orbital injection
Organism or Cell Type:
humanized DMD mice
Citation Extract:
Melo D, Maruyama R, Yokota T. Systemic Injection of Peptide-PMOs into Humanized DMD Mice and Detection by RT-PCR and ELISA. Methods Mol Biol. 2025;2964:231-242. doi: 10.1007/978-1-0716-4730-1_15. PMID: 40720022.

In Vivo Evaluation of Single- and Multi-Exon-Skipping in mdx52 Mice

Authors:
Sathyaprakash C, Takeuchi E, Takizawa H, Ashida Y, Tominari T, Echigoya Y, Yokota T, Aoki Y
Citation:
Methods Mol Biol. 2025;2964:243-261. doi: 10.1007/978-1-0716-4730-1_16. PMID: 40720023
Epub:
Not Epub
Abstract:
Exon-skipping therapy is an emerging approach that uses synthetic DNA-like molecules called antisense oligonucleotides (ASOs)...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_16
Delivery Method:
intravenous (i.v.) injection
Organism or Cell Type:
mdx52 mice
Citation Extract:
Sathyaprakash C, Takeuchi E, Takizawa H, Ashida Y, Tominari T, Echigoya Y, Yokota T, Aoki Y. In Vivo Evaluation of Single- and Multi-Exon-Skipping in mdx52 Mice. Methods Mol Biol. 2025;2964:243-261. doi: 10.1007/978-1-0716-4730-1_16. PMID: 40720023.

ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis

Authors:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP
Citation:
Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628
Epub:
Not Epub
Abstract:
T lymphocytes, which are essential for cell-mediated immunity in vertebrates, rely on thymic seeding of lymphoid progenitors...
Link:
https://www.nature.com/articles/s41467-025-61680-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP. ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis. Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628.

ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis

Authors:
Choi DY, Leem J, Lee C, Oh JS
Citation:
Genome Biol. 2025 Jul 15;26(1):204. doi: 10.1186/s13059-025-03687-3. PMID: 40665375; PMCID: PMC12261598
Epub:
Not Epub
Abstract:
Background: Centromeres play a vital role in ensuring accurate chromosome segregation during meiosis by serving as the...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12261598/
Delivery Method:
microinjection
Organism or Cell Type:
CD1 mouse oocysts
Citation Extract:
Choi DY, Leem J, Lee C, Oh JS. ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis. Genome Biol. 2025 Jul 15;26(1):204. doi: 10.1186/s13059-025-03687-3. PMID: 40665375; PMCID: PMC12261598.

Transient versican expression is required for β1-integrin accumulation during podocyte layer morphogenesis in amphibian developing kidney

Authors:
Buisson I, Riou JF, Umbhauer M, Le Bouffant R, Bello V
Citation:
Cells Dev. 2025 Dec 13;185:204062. doi: 10.1016/j.cdev.2025.204062. Epub ahead of print. PMID: 41397522
Epub:
Not Epub
Abstract:
The functional organization of the vertebrate nephron is remarkably conserved, yet the morphogenetic processes underlying...
Link:
https://www.sciencedirect.com/science/article/pii/S2667290125000695
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Buisson I, Riou JF, Umbhauer M, Le Bouffant R, Bello V. Transient versican expression is required for β1-integrin accumulation during podocyte layer morphogenesis in amphibian developing kidney. Cells Dev. 2025 Dec 13;185:204062. doi: 10.1016/j.cdev.2025.204062. Epub ahead of print. PMID: 41397522.

Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse

Authors:
Schneider AE, Tanganyika-de Winter CL, Jirka SMG, Tan X, Thompson EG, Ha K, Mitra A, Garcia S, Luimes M, Oliver RA, Guerlavais V, Aartsma-Rus A
Citation:
Mol Ther Nucleic Acids. 2025 Jul 17;36(3):102625. doi: 10.1016/j.omtn.2025.102625. PMID: 40777739; PMCID: PMC12329520
Epub:
Not Epub
Abstract:
The severe muscle wasting disorder Duchenne muscular dystrophy (DMD) is characterized by the absence of dystrophin, a protein...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12329520/
Delivery Method:
CP10 and acetyl-R6Gly peptide-linked; intravenous (i.v.)
Organism or Cell Type:
mdx mice
Citation Extract:
Schneider AE, Tanganyika-de Winter CL, Jirka SMG, Tan X, Thompson EG, Ha K, Mitra A, Garcia S, Luimes M, Oliver RA, Guerlavais V, Aartsma-Rus A. Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse. Mol Ther Nucleic Acids. 2025 Jul 17;36(3):102625. doi: 10.1016/j.omtn.2025.102625. PMID: 40777739; PMCID: PMC12329520.

Pages