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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity

Authors:
Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL
Citation:
ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648
Epub:
Yes
Abstract:
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise nonpenetrant...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10114648/
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa 654
Citation Extract:
Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL. Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity. ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648.

Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers

Authors:
Kobayashi Y, Chhoeu C, Li J, Price KS, Kiedrowski LA, Hutchins JL, Hardin AI, Wei Z, Hong F, Bahcall M, Gokhale PC, Jänne PA
Citation:
Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print
Epub:
Yes
Abstract:
RAS family members are the most frequently mutated oncogenes in human cancers. Although KRAS(G12C)-specific inhibitors show...
Link:
https://www.nature.com/articles/s41586-022-04451-4
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
xenograft in mice
Citation Extract:
Kobayashi Y, Chhoeu C, Li J, Price KS, Kiedrowski LA, Hutchins JL, Hardin AI, Wei Z, Hong F, Bahcall M, Gokhale PC, Jänne PA. Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers. Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print.

Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish

Authors:
Magner E, Sandoval-Sanchez P, Kramer AC, Thummel R, Hitchcock PF, Taylor SM
Citation:
Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print
Epub:
Yes
Abstract:
In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller...
Link:
https://link.springer.com/article/10.1007/s12035-022-02783-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Magner E, Sandoval-Sanchez P, Kramer AC, Thummel R, Hitchcock PF, Taylor SM. Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print.

The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1

Authors:
Zhou H, Shen C, Guo Y, Huang X, Zheng B, Wu Y
Citation:
Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print
Epub:
Yes
Abstract:
Background: Spermatogonial stem cells (SSCs) are unique stem cells that account for the whole reproductive life of males and...
Link:
https://link.springer.com/article/10.1007/s11033-022-07289-1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
murine explants
Citation Extract:
Zhou H, Shen C, Guo Y, Huang X, Zheng B, Wu Y. The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1. Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print.

Maternal thyroid hormone increases neural cell diversity during zebrafish spinal cord neurodevelopment

Authors:
Silva N, Campinho MA
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.02.26.482108
Epub:
Not Epub
Abstract:
Maternally derived thyroid hormone (MT3) is a fundamental factor for vertebrate neurodevelopment. In humans, mutations on the...
Link:
https://www.biorxiv.org/content/10.1101/2022.02.26.482108v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Silva N, Campinho MA. Maternal thyroid hormone increases neural cell diversity during zebrafish spinal cord neurodevelopment. bioRxiv. 2022;[preprint] doi:10.1101/2022.02.26.482108.

Zebrafish her3 knockout impacts developmental and cancer-related gene signatures

Authors:
Kent MR, Calderon D, Silvius KM, LaVigne CA, Cannon MV, Kendall GC
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.02.25.482038
Epub:
Not Epub
Abstract:
HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3...
Link:
https://www.biorxiv.org/content/10.1101/2022.02.25.482038v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kent MR, Calderon D, Silvius KM, LaVigne CA, Cannon MV, Kendall GC. Zebrafish her3 knockout impacts developmental and cancer-related gene signatures. bioRxiv. 2022;[preprint] doi:10.1101/2022.02.25.482038.

Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells

Authors:
Galarza-Muñoz G, Kennedy-Boone D, Schott G, Bradrick SS, Garcia-Blanco MA
Citation:
bioRxiv. 2022;[preprint] doi:doi.org/10.1101/2022.02.22.481529
Epub:
Not Epub
Abstract:
The interleukin 7 receptor (IL7R) is strongly associated with increased risk to develop multiple sclerosis (MS), an autoimmune...
Link:
https://www.biorxiv.org/content/10.1101/2022.02.22.481529v1.full
Delivery Method:
Endo-Porter PEG (HeLa), electroporation (primary CD4+ T)
Organism or Cell Type:
cell culture: HeLa, human primary CD4+ T cells
Citation Extract:
Galarza-Muñoz G, Kennedy-Boone D, Schott G, Bradrick SS, Garcia-Blanco MA. Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells. bioRxiv. 2022;[preprint] doi:doi.org/10.1101/2022.02.22.481529.

Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery

Authors:
Zhao H, Sun J, Insinna C, Lu Q, Wang Z, Nagashima K, Stauffer J, Andresson T, Specht S, Perera S, Daar IO, Westlake CJ
Citation:
EMBO Rep. 2022 Feb 24:e52775. doi: 10.15252/embr.202152775. Online ahead of print
Epub:
Not Epub
Abstract:
Motile cilia on the cell surface generate movement and directional fluid flow that is crucial for various biological processes...
Link:
https://www.embopress.org/doi/full/10.15252/embr.202152775
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus, zebrafish
Citation Extract:
Zhao H, Sun J, Insinna C, Lu Q, Wang Z, Nagashima K, Stauffer J, Andresson T, Specht S, Perera S, Daar IO, Westlake CJ. Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery. EMBO Rep. 2022 Feb 24:e52775. doi: 10.15252/embr.202152775. Online ahead of print.

SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal

Authors:
Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD
Citation:
Dev Cell. 2022 Feb 22:S1534-5807(22)00036-3. doi: 10.1016/j.devcel.2022.01.011. Online ahead of print
Epub:
Not Epub
Abstract:
Alternative splicing generates distinct mRNA variants and is essential for development, homeostasis, and renewal. Proteins of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580722000363
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: primary murine cells: dental epithelium, intestinal organoid crypt
Citation Extract:
Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD. SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal. Dev Cell. 2022 Feb 22:S1534-5807(22)00036-3. doi: 10.1016/j.devcel.2022.01.011. Online ahead of print.

A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis

Authors:
Kumar R, Francis V, Kulasekaran G, Khan M, Armstrong GAB, McPherson PS
Citation:
Sci Adv. 2022 Feb 25;8(8):eabk3088. doi: 10.1126/sciadv.abk3088. Epub 2022 Feb 23
Epub:
Not Epub
Abstract:
Primary cilia are sensory antennae crucial for cell and organism development, and defects in their biogenesis cause...
Link:
https://www.science.org/doi/10.1126/sciadv.abk3088
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kumar R, Francis V, Kulasekaran G, Khan M, Armstrong GAB, McPherson PS. A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis. Sci Adv. 2022 Feb 25;8(8):eabk3088. doi: 10.1126/sciadv.abk3088. Epub 2022 Feb 23.

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