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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12455 scientific papers returned from the database with the search filters currently being used below.

Formation control between leader and migratory follower tissues allows coordinated growth

Authors:
Kawanishi T, Sushida T, Tsai TY, Takeda H, Megason SG
Citation:
Sci Adv. 2025 Aug;11(31):eads2310. doi: 10.1126/sciadv.ads2310. Epub 2025 Jul 30. PMID: 40737421; PMCID: PMC12309693
Epub:
Not Epub
Abstract:
Coordinated growth of multiple tissues is fundamental to shaping our body, but the underlying mechanisms remain underexplored....
Link:
https://www.science.org/doi/10.1126/sciadv.ads2310
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kawanishi T, Sushida T, Tsai TY, Takeda H, Megason SG. Formation control between leader and migratory follower tissues allows coordinated growth. Sci Adv. 2025 Aug;11(31):eads2310. doi: 10.1126/sciadv.ads2310. Epub 2025 Jul 30. PMID: 40737421; PMCID: PMC12309693.

Self-Assembling Multi-Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Authors:
Li S, Li J, Faruque HA, Shami P, Knoechel B, Lohr J, Sborov D, Yang J, Kopeček J
Citation:
Adv Healthc Mater. 2025 Aug 1:e02156. doi: 10.1002/adhm.202502156. Epub ahead of print. PMID: 40747784
Epub:
Not Epub
Abstract:
Bispecific T-cell engagers show promise in treating multiple myeloma (MM), but challenges remain in adaptability and targeting...
Link:
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502156
Delivery Method:
Fab-linked; mice: intravenous (i.v.) injection
Organism or Cell Type:
Multiple myeloma cells (MM.1S, MM.1R, RPMI-8226, ANBL-6, and U266), human PBMCs, primary T cells; mice: NRG (NOD-Rag1−/−IL2Rγnull)
Citation Extract:
Li S, Li J, Faruque HA, Shami P, Knoechel B, Lohr J, Sborov D, Yang J, Kopeček J. Self-Assembling Multi-Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma. Adv Healthc Mater. 2025 Aug 1:e02156. doi: 10.1002/adhm.202502156. Epub ahead of print. PMID: 40747784.

Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia

Authors:
Yeo HR, Shin MY, Kim J, Park SJ
Citation:
Microbiologyopen. 2025 Aug;14(4):e70038. doi: 10.1002/mbo3.70038. PMID: 40734239; PMCID: PMC12307541
Epub:
Not Epub
Abstract:
Centrins, Ca2+-binding proteins conserved in eukaryotes, are the key components of the microtubule-organizing center. Giardia...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mbo3.70038
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Yeo HR, Shin MY, Kim J, Park SJ. Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia. Microbiologyopen. 2025 Aug;14(4):e70038. doi: 10.1002/mbo3.70038. PMID: 40734239; PMCID: PMC12307541.

FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A

Authors:
Kastens G, Berger-Santangelo H, Gerstner S, Ufartes R, Mischak M, Borchers A, Pauli S
Citation:
Hum Genet. 2025 Jul 14. doi: 10.1007/s00439-025-02760-y. Epub ahead of print. PMID: 40658195
Epub:
Not Epub
Abstract:
FBRSL1-associated syndrome is a rare congenital malformation and intellectual disability syndrome caused by heterozygous...
Link:
https://link.springer.com/article/10.1007/s00439-025-02760-y
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kastens G, Berger-Santangelo H, Gerstner S, Ufartes R, Mischak M, Borchers A, Pauli S. FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A. Hum Genet. 2025 Jul 14. doi: 10.1007/s00439-025-02760-y. Epub ahead of print. PMID: 40658195.

Morpholino-Mediated Exon Inclusion for Spinal Muscular Atrophy (SMA)

Authors:
Zhou H, Muntoni F
Citation:
Methods Mol Biol. 2025;2964:433-444. doi: 10.1007/978-1-0716-4730-1_28. PMID: 40720035
Epub:
Not Epub
Abstract:
The application of antisense oligonucleotides (AONs) to modify pre-messenger RNA splicing has great potential for treating...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_28
Organism or Cell Type:
SMA mice
Citation Extract:
Zhou H, Muntoni F. Morpholino-Mediated Exon Inclusion for Spinal Muscular Atrophy (SMA). Methods Mol Biol. 2025;2964:433-444. doi: 10.1007/978-1-0716-4730-1_28. PMID: 40720035.

Systemic Injection of Antisense Oligos into Spinal Muscular Atrophy (SMA) Mice and Evaluation

Authors:
Aslesh T, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2025;2964:421-431. doi: 10.1007/978-1-0716-4730-1_27. PMID: 40720034
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is the most common genetic cause of infantile death caused by mutations in the SMN1 gene....
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_27
Delivery Method:
intracerebroventricular (i.c.v.) injection
Organism or Cell Type:
SMA mice
Citation Extract:
Aslesh T, Maruyama R, Yokota T. Systemic Injection of Antisense Oligos into Spinal Muscular Atrophy (SMA) Mice and Evaluation. Methods Mol Biol. 2025;2964:421-431. doi: 10.1007/978-1-0716-4730-1_27. PMID: 40720034.

Systemic Injection of Peptide-PMOs into Humanized DMD Mice and Detection by RT-PCR and ELISA

Authors:
Melo D, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2025;2964:231-242. doi: 10.1007/978-1-0716-4730-1_15. PMID: 40720022
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder due to the lack of dystrophin production. The disease is...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_15
Delivery Method:
peptide-linked; mice: retro-orbital injection
Organism or Cell Type:
humanized DMD mice
Citation Extract:
Melo D, Maruyama R, Yokota T. Systemic Injection of Peptide-PMOs into Humanized DMD Mice and Detection by RT-PCR and ELISA. Methods Mol Biol. 2025;2964:231-242. doi: 10.1007/978-1-0716-4730-1_15. PMID: 40720022.

In Vivo Evaluation of Single- and Multi-Exon-Skipping in mdx52 Mice

Authors:
Sathyaprakash C, Takeuchi E, Takizawa H, Ashida Y, Tominari T, Echigoya Y, Yokota T, Aoki Y
Citation:
Methods Mol Biol. 2025;2964:243-261. doi: 10.1007/978-1-0716-4730-1_16. PMID: 40720023
Epub:
Not Epub
Abstract:
Exon-skipping therapy is an emerging approach that uses synthetic DNA-like molecules called antisense oligonucleotides (ASOs)...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_16
Delivery Method:
intravenous (i.v.) injection
Organism or Cell Type:
mdx52 mice
Citation Extract:
Sathyaprakash C, Takeuchi E, Takizawa H, Ashida Y, Tominari T, Echigoya Y, Yokota T, Aoki Y. In Vivo Evaluation of Single- and Multi-Exon-Skipping in mdx52 Mice. Methods Mol Biol. 2025;2964:243-261. doi: 10.1007/978-1-0716-4730-1_16. PMID: 40720023.

Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms

Authors:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P
Citation:
bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170
Epub:
Not Epub
Abstract:
Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β...
Link:
https://www.biorxiv.org/content/10.1101/2024.10.27.620464v3.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P. Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms. bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170.

ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis

Authors:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP
Citation:
Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628
Epub:
Not Epub
Abstract:
T lymphocytes, which are essential for cell-mediated immunity in vertebrates, rely on thymic seeding of lymphoid progenitors...
Link:
https://www.nature.com/articles/s41467-025-61680-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP. ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis. Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628.

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