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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1

Authors:
Shiba N, Yang X, Sato M, Kadota S, Suzuki Y, Agata M, Nagamine K, Izumi M, Honda Y, Koganehira T, Kobayashi H, Ichimura H, Chuma S, Nakai J, Tohyama S, Fukuda K, Miyazaki D, Nakamura A, Shiba Y
Citation:
Mol Ther Nucleic Acids. 2023 Oct 19;34:102060. doi: 10.1016/j.omtn.2023.102060. eCollection 2023 Dec 12
Epub:
Not Epub
Abstract:
Exon-skipping therapy is a promising treatment strategy for Duchenne muscular dystrophy (DMD), which is caused by loss-of-...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00278-0
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: hiPSC-CMs
Citation Extract:
Shiba N, Yang X, Sato M, Kadota S, Suzuki Y, Agata M, Nagamine K, Izumi M, Honda Y, Koganehira T, Kobayashi H, Ichimura H, Chuma S, Nakai J, Tohyama S, Fukuda K, Miyazaki D, Nakamura A, Shiba Y. Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1. Mol Ther Nucleic Acids. 2023 Oct 19;34:102060. doi: 10.1016/j.omtn.2023.102060. eCollection 2023 Dec 12.

A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis?

Authors:
Rice KL, Chan CM, Kelu JJ, Miller AL, Webb SE
Citation:
Contact (Thousand Oaks). 2023 Nov 7;6:25152564231211409. doi: 10.1177/25152564231211409
Epub:
Not Epub
Abstract:
We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca2+...
Link:
https://journals.sagepub.com/doi/10.1177/25152564231211409
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rice KL, Chan CM, Kelu JJ, Miller AL, Webb SE. A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis?. Contact (Thousand Oaks). 2023 Nov 7;6:25152564231211409. doi: 10.1177/25152564231211409.

Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation

Authors:
Lin Y, Yang Q, Lin X, Liu X, Qian Y, Xu D, Cao N, Han X, Zhu Y, Hu W, He X, Yu Z, Kong X, Zhu L, Zhong Z, Liu K, Zhou B, Wang Y, Peng J, Zhu W, Wang J
Citation:
Circulation. 2023 Nov 29. doi: 10.1161/CIRCULATIONAHA.123.065458. Online ahead of print
Epub:
Not Epub
Abstract:
Background: A better understanding of the molecular mechanism of aortic valve development and bicuspid aortic valve (BAV)...
Link:
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065458
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin Y, Yang Q, Lin X, Liu X, Qian Y, Xu D, Cao N, Han X, Zhu Y, Hu W, He X, Yu Z, Kong X, Zhu L, Zhong Z, Liu K, Zhou B, Wang Y, Peng J, Zhu W, Wang J. Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation. 2023 Nov 29. doi: 10.1161/CIRCULATIONAHA.123.065458. Online ahead of print.

Biallelic COQ4 Variants in Hereditary Spastic Paraplegia: Clinical and Molecular Characterization

Authors:
Lin X, Jiang JY, Hong DJ, Lin KJ, Li JJ, Chen YJ, Qiu YS, Wang Z, Liao YC, Yang K, Shi Y, Wang MW, Hsu SL, Hong S, Zeng YH, Chen XC, Wang N, Lee YC, Chen WJ
Citation:
Mov Disord. 2023 Nov 28. doi: 10.1002/mds.29664. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Hereditary spastic paraplegias (HSP) are neurologic disorders characterized by progressive lower-extremity...
Link:
https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.29664
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin X, Jiang JY, Hong DJ, Lin KJ, Li JJ, Chen YJ, Qiu YS, Wang Z, Liao YC, Yang K, Shi Y, Wang MW, Hsu SL, Hong S, Zeng YH, Chen XC, Wang N, Lee YC, Chen WJ. Biallelic COQ4 Variants in Hereditary Spastic Paraplegia: Clinical and Molecular Characterization. Mov Disord. 2023 Nov 28. doi: 10.1002/mds.29664. Online ahead of print.

ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae

Authors:
Seidl MJ, Scharre S, Posset R, Druck A-C, Epp F, Okun JG, Dimitrov B, Hoffmann GF, Kölker S, Zielonka M
Citation:
Mol Genet Metab. 2023;108097:[Epub] doi:10.1016/j.ymgme.2023.108097
Epub:
Not Epub
Abstract:
Citrullinemia type 1 (CTLN1) is a rare autosomal recessive urea cycle disorder caused by deficiency of the cytosolic enzyme...
Link:
https://www.sciencedirect.com/science/article/pii/S1096719223007278
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Seidl MJ, Scharre S, Posset R, Druck A-C, Epp F, Okun JG, Dimitrov B, Hoffmann GF, Kölker S, Zielonka M. ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae. Mol Genet Metab. 2023;108097:[Epub] doi:10.1016/j.ymgme.2023.108097.

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

Authors:
Colozza G, Lee H, Merenda A, Wu SS, Català-Bordes A, Radaszkiewicz TW, Jordens I, Lee JH, Bamford AD, Farnhammer F, Low TY, Maurice MM, Bryja V, Kim J, Koo BK
Citation:
Sci Adv. 2023 Nov 24;9(47):eadh9673. doi: 10.1126/sciadv.adh9673. Epub 2023 Nov 24
Epub:
Not Epub
Abstract:
The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem cells residing at the crypt bottom....
Link:
https://www.science.org/doi/10.1126/sciadv.adh9673
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Colozza G, Lee H, Merenda A, Wu SS, Català-Bordes A, Radaszkiewicz TW, Jordens I, Lee JH, Bamford AD, Farnhammer F, Low TY, Maurice MM, Bryja V, Kim J, Koo BK. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Sci Adv. 2023 Nov 24;9(47):eadh9673. doi: 10.1126/sciadv.adh9673. Epub 2023 Nov 24.

Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development

Authors:
Takada Y, Fierro L, Sato K, Sanada T, Ishii A, Yamamoto T, Kotani T
Citation:
Sci Adv. 2023 Nov 24;9(47):eadg6532. doi: 10.1126/sciadv.adg6532. Epub 2023 Nov 24
Epub:
Not Epub
Abstract:
Eggs accumulate thousands of translationally repressed mRNAs that are translated into proteins after fertilization to direct...
Link:
https://www.science.org/doi/10.1126/sciadv.adg6532
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Takada Y, Fierro L, Sato K, Sanada T, Ishii A, Yamamoto T, Kotani T. Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development. Sci Adv. 2023 Nov 24;9(47):eadg6532. doi: 10.1126/sciadv.adg6532. Epub 2023 Nov 24.

Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry

Authors:
Eggeler F, Boulanger-Weill J, De Santis F, Belleri L, Duroure K, Auer TO, Albadri S, Del Bene F
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.23.568438
Epub:
Not Epub
Abstract:
The body plan of vertebrates appears externally bilaterally symmetric. Nonetheless the positioning and morphology of internal...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.23.568438v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Eggeler F, Boulanger-Weill J, De Santis F, Belleri L, Duroure K, Auer TO, Albadri S, Del Bene F. Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.23.568438.

Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases

Authors:
Cheng X, Barakat R, Pavani G, Usha MK, Calderon R, Snella E, Gorden A, Zhang Y, Gadue P, French DL, Dorman KS, Fidanza A, Campbell CA, Espin-Palazon R
Citation:
Nat Commun. 2023 Nov 23;14(1):7668. doi: 10.1038/s41467-023-43349-1
Epub:
Not Epub
Abstract:
Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to...
Link:
https://www.nature.com/articles/s41467-023-43349-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng X, Barakat R, Pavani G, Usha MK, Calderon R, Snella E, Gorden A, Zhang Y, Gadue P, French DL, Dorman KS, Fidanza A, Campbell CA, Espin-Palazon R. Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases. Nat Commun. 2023 Nov 23;14(1):7668. doi: 10.1038/s41467-023-43349-1.

ERBB3 deficiency causes a multisystemic syndrome in human patient and zebrafish

Authors:
Liu K, Chen R, Zhang M, Gong Y, Wang Y, Cai W
Citation:
Clin Genet. 2023 Nov 27. doi: 10.1111/cge.14462. Online ahead of print
Epub:
Yes
Abstract:
The Erb-B2 receptor tyrosine kinase 3 (ERBB3) gene was first identified as a cause of lethal congenital contracture syndrome (...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.14462
Organism or Cell Type:
zebrafish
Citation Extract:
Liu K, Chen R, Zhang M, Gong Y, Wang Y, Cai W. ERBB3 deficiency causes a multisystemic syndrome in human patient and zebrafish. Clin Genet. 2023 Nov 27. doi: 10.1111/cge.14462. Online ahead of print.

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