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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling

Authors:
Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.563773
Epub:
Not Epub
Abstract:
Wnt signaling is a crucial developmental pathway involved in early development as well as stem cell maintenance in adults and...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.30.563773v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ. Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.563773.

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia

Authors:
Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN
Citation:
Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3
Epub:
Not Epub
Abstract:
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and...
Link:
https://www.science.org/doi/10.1126/sciadv.adi4777
Delivery Method:
nanoparticle intraperitoneal (i.p.)
Organism or Cell Type:
mice
Citation Extract:
Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN. Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3.

Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix

Authors:
Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565243
Epub:
Not Epub
Abstract:
Embryonic development is orchestrated by the action of morphogens, which spread out from a local source and activate, in a...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.02.565243v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M. Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565243.

Candida albicans suppression of neutrophil reactive nitrogen species is rescued by host Hif-1α in vivo

Authors:
Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Ayscough KR, Johnston SA, Condliffe AM, Elks PM
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565128
Epub:
Not Epub
Abstract:
Candida spp. cause 750,000 cases per annum of invasive disease worldwide, with up to a 50% mortality rate. Poor efficacy of...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.02.565128v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Ayscough KR, Johnston SA, Condliffe AM, Elks PM. Candida albicans suppression of neutrophil reactive nitrogen species is rescued by host Hif-1α in vivo. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565128.

Analysis of Vascular Morphogenesis in Zebrafish

Authors:
Hubert M, Herzog W
Citation:
Methods Mol Biol. 2023;2608:425-450. doi: 10.1007/978-1-0716-2887-4_24
Epub:
Not Epub
Abstract:
Analysis of cardiovascular development in zebrafish embryos has become a major driver of vascular research in recent years....
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2887-4_24
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hubert M, Herzog W. Analysis of Vascular Morphogenesis in Zebrafish. Methods Mol Biol. 2023;2608:425-450. doi: 10.1007/978-1-0716-2887-4_24.

Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates

Authors:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR
Citation:
ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634
Epub:
Yes
Abstract:
Fuchs’ corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective...
Link:
https://pubs.acs.org/doi/10.1021/acsomega.3c05634
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: FECD patient-derived F35T corneal endothelial cells
Citation Extract:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR. Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates. ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634.

nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling

Authors:
Yang S, Xu X, Yin Z, Liu Y, Wang H, Guo J, Wang F, Bao Y, Zhang T, Sun S
Citation:
Heliyon. 2023;[Epub] doi:10.1016/j.heliyon.2023.e21915
Epub:
Not Epub
Abstract:
Nkx2.3, a transcription factor, plays important roles in various developmental processes. However, the mechanisms underlying...
Link:
https://www.cell.com/heliyon/fulltext/S2405-8440(23)09123-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang S, Xu X, Yin Z, Liu Y, Wang H, Guo J, Wang F, Bao Y, Zhang T, Sun S. nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling. Heliyon. 2023;[Epub] doi:10.1016/j.heliyon.2023.e21915.

Gαi2-Mediated Regulation of Microtubules Dynamics and Rac1 Activity Orchestrates Cranial Neural Crest Cell Migration in Xenopus

Authors:
Villaseca S, Leal JI, Guajardo J, Morales-Navarrete H, Mayor R, Torrejón M
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.09.07.556733
Epub:
Not Epub
Abstract:
Cell migration is a complex and essential process in various biological contexts, from embryonic development to tissue repair...
Link:
https://www.biorxiv.org/content/10.1101/2023.09.07.556733v2
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Villaseca S, Leal JI, Guajardo J, Morales-Navarrete H, Mayor R, Torrejón M. Gαi2-Mediated Regulation of Microtubules Dynamics and Rac1 Activity Orchestrates Cranial Neural Crest Cell Migration in Xenopus. bioRxiv. 2023;[preprint] doi:10.1101/2023.09.07.556733.

Siderophore-Mediated Conveyance of Antibacterial-Antisense Oligomers

Authors:
Pals MJ, Wijnberg L, Yildiz Ç, Velema WA
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.564798
Epub:
Not Epub
Abstract:
Antibacterial resistance is a major threat for human health. There is a need for new antibacterials to stay ahead of constantly...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.30.564798v1
Delivery Method:
siderophore-linked
Organism or Cell Type:
cell culture: Escherichia coli
Citation Extract:
Pals MJ, Wijnberg L, Yildiz Ç, Velema WA. Siderophore-Mediated Conveyance of Antibacterial-Antisense Oligomers. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.564798.

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz

Authors:
Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M, Takeuchi O
Citation:
Blood. 2023 Nov 3:blood.2023020903. doi: 10.1182/blood.2023020903. Online ahead of print
Epub:
Yes
Abstract:
Regulation of lineage biases in hematopoietic stem and progenitor cells (HSPCs) is pivotal for balanced hematopoietic output....
Link:
https://ashpublications.org/blood/article/doi/10.1182/blood.2023020903/498619/Regulation-of-lymphoid-myeloid-lineage-bias
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: hematopoetic stem cells
Citation Extract:
Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M, Takeuchi O. Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz. Blood. 2023 Nov 3:blood.2023020903. doi: 10.1182/blood.2023020903. Online ahead of print.

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