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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Nerve-independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3

Authors:
Kwan HR, Chan ZC, Bi X, Kutkowska J, Prószyński TJ, Chan CB, Lee CW
Citation:
Sci Adv. 2023 Jun 16;9(24):eadg0183. doi: 10.1126/sciadv.adg0183. Epub 2023 Jun 16
Epub:
Not Epub
Abstract:
Junctional folds are unique membrane specializations developed progressively during the postnatal maturation of vertebrate...
Link:
https://www.science.org/doi/10.1126/sciadv.adg0183
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kwan HR, Chan ZC, Bi X, Kutkowska J, Prószyński TJ, Chan CB, Lee CW. Nerve-independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3. Sci Adv. 2023 Jun 16;9(24):eadg0183. doi: 10.1126/sciadv.adg0183. Epub 2023 Jun 16.

Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism

Authors:
Darrah KE, Albright S, Kumbhare R, Tsang M, Chen JK, Deiters A
Citation:
ACS Chem Biol. 2023 Jun 16. doi: 10.1021/acschembio.3c00027. Online ahead of print
Epub:
Yes
Abstract:
The structure and mechanism of the bacterial enzyme β-lactamase have been well-studied due to its clinical role in antibiotic...
Link:
https://pubs.acs.org/doi/10.1021/acschembio.3c00027
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Darrah KE, Albright S, Kumbhare R, Tsang M, Chen JK, Deiters A. Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism. ACS Chem Biol. 2023 Jun 16. doi: 10.1021/acschembio.3c00027. Online ahead of print.

Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway

Authors:
Zhang H, Meng L, Liu Y, Jiang J, He Z, Qin J, Wang C, Yang M, He K, Yang J, Chen K, He Q, Tang W, Fan S, Ren C
Citation:
J Immunol. 2023 Jun 16:ji2200863. doi: 10.4049/jimmunol.2200863. Online ahead of print
Epub:
Yes
Abstract:
Cell spreading is an initial and critical step in neutrophil adhesion and migration, leading to neutrophil recruitment to...
Link:
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200863/265709/Sfxn5-Regulation-of-Actin-Polymerization-for
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang H, Meng L, Liu Y, Jiang J, He Z, Qin J, Wang C, Yang M, He K, Yang J, Chen K, He Q, Tang W, Fan S, Ren C. Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. J Immunol. 2023 Jun 16:ji2200863. doi: 10.4049/jimmunol.2200863. Online ahead of print.

Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs)

Authors:
Malecova B, Burke RS, Cochran M, Hood MD, Johns R, Kovach PR, Doppalapudi VR, Erdogan G, Arias JD, Darimont B, Miller CD, Huang H, Geall A, Younis HS, Levin AA
Citation:
Nucleic Acids Res. 2023 May 24:gkad415. doi: 10.1093/nar/gkad415. Online ahead of print
Epub:
Yes
Abstract:
Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad415/7177882
Delivery Method:
antibody-linked
Organism or Cell Type:
mice
Citation Extract:
Malecova B, Burke RS, Cochran M, Hood MD, Johns R, Kovach PR, Doppalapudi VR, Erdogan G, Arias JD, Darimont B, Miller CD, Huang H, Geall A, Younis HS, Levin AA. Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs). Nucleic Acids Res. 2023 May 24:gkad415. doi: 10.1093/nar/gkad415. Online ahead of print.

The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit

Authors:
Villegas-Esguevillas M, Cho S, Vera-Zambrano A, Kwon JW, Barreira B, Telli G, Navarro-Dorado J, Morales-Cano D, de Olaiz B, Moreno L, Greenwood I, Pérez-Vizcaíno F, Kim SJ, Climent B, Cogolludo A
Citation:
Biomed Pharmacother. 2023 Jun 7;164:114952. doi: 10.1016/j.biopha.2023.114952. Online ahead of print
Epub:
Not Epub
Abstract:
KV7 channels exert a pivotal role regulating vascular tone in several vascular beds. In this context, KV7 channel agonists...
Link:
https://www.sciencedirect.com/science/article/pii/S0753332223007424
Delivery Method:
Lipofectamine
Organism or Cell Type:
cell culture: isolated pulmonary artery (PA) cells
Citation Extract:
Villegas-Esguevillas M, Cho S, Vera-Zambrano A, Kwon JW, Barreira B, Telli G, Navarro-Dorado J, Morales-Cano D, de Olaiz B, Moreno L, Greenwood I, Pérez-Vizcaíno F, Kim SJ, Climent B, Cogolludo A. The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. Biomed Pharmacother. 2023 Jun 7;164:114952. doi: 10.1016/j.biopha.2023.114952. Online ahead of print.

Plexina4 and cell survival in the developing zebrafish hindbrain

Authors:
Nurcombe ZW, Hehr CL, McFarlane S
Citation:
Dev Dyn. 2023 Jun 7. doi: 10.1002/dvdy.633. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Growth factors are important in the developing and mature nervous system to support the survival of neurons....
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.633
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nurcombe ZW, Hehr CL, McFarlane S. Plexina4 and cell survival in the developing zebrafish hindbrain. Dev Dyn. 2023 Jun 7. doi: 10.1002/dvdy.633. Online ahead of print.

Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl

Authors:
Bay S, Öztürk G, Emekli N, Demircan T
Citation:
Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print
Epub:
Not Epub
Abstract:
The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160623000945
Delivery Method:
injection then electroporation
Organism or Cell Type:
Ambystoma mexicanum (Axolotl)
Citation Extract:
Bay S, Öztürk G, Emekli N, Demircan T. Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl. Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print.

Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia

Authors:
Bai MR, Pei HY, Zhou Y, Song HL, Pan WH, Gong YM, Wu WJ, Yu WW, Cui MM, Gu BL, Chu X, Cai W
Citation:
Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023
Epub:
Not Epub
Abstract:
Background: Biliary atresia (BA) is a destructive, obliterative cholangiopathy characterized by progressive fibro-inflammatory...
Link:
https://www.frontiersin.org/articles/10.3389/fgene.2023.1186882/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bai MR, Pei HY, Zhou Y, Song HL, Pan WH, Gong YM, Wu WJ, Yu WW, Cui MM, Gu BL, Chu X, Cai W. Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023.

Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo

Authors:
Del Rio R Jr, Serrano RG, Gomez E, Martinez JC, Edward MA, Santos RA, Diaz KS, Cohen-Cory S
Citation:
Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023
Epub:
Not Epub
Abstract:
Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to...
Link:
https://www.frontiersin.org/articles/10.3389/fnsyn.2023.1176864/full
Delivery Method:
electroporation
Organism or Cell Type:
Xenopus laevis tadpoles
Citation Extract:
Del Rio R Jr, Serrano RG, Gomez E, Martinez JC, Edward MA, Santos RA, Diaz KS, Cohen-Cory S. Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo. Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023.

The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs

Authors:
Feng Q, Lin Z, Deng Y, Ran Y, Yu R, Xiang AP, Ye C, Yao C
Citation:
J Biol Chem. 2023 May 22:104854. doi: 10.1016/j.jbc.2023.104854. Online ahead of print
Epub:
Yes
Abstract:
Functional depletion of the U1 small nuclear ribonucleoprotein (snRNP) with a 25 nt U1 AMO (antisense morpholino...
Link:
https://www.jbc.org/article/S0021-9258(23)01882-3/fulltext
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Feng Q, Lin Z, Deng Y, Ran Y, Yu R, Xiang AP, Ye C, Yao C. The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs. J Biol Chem. 2023 May 22:104854. doi: 10.1016/j.jbc.2023.104854. Online ahead of print.

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