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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis

Authors:
Heng J, Shi B, Zhou JY, Zhang Y, Ma D, Yang YG, Liu F
Citation:
Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212212120. doi: 10.1073/pnas.2212212120. Epub 2023 Feb 6
Epub:
Not Epub
Abstract:
During vertebrate embryogenesis, hematopoietic stem and progenitor cell (HSPC) production through endothelial-to-hematopoietic...
Link:
https://www.pnas.org/doi/10.1073/pnas.2212212120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Heng J, Shi B, Zhou JY, Zhang Y, Ma D, Yang YG, Liu F. Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212212120. doi: 10.1073/pnas.2212212120. Epub 2023 Feb 6.

Gaucher disease protects against tuberculosis

Authors:
Fan J, Hale VL, Lelieveld LT, Ramakrishna L
Citation:
Proc Natl Acad Sci USA. 2023;120(7):e2217673120 doi:10.1073/pnas.2217673120
Epub:
Not Epub
Abstract:
Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of...
Link:
https://www.pnas.org/doi/10.1073/pnas.2217673120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fan J, Hale VL, Lelieveld LT, Ramakrishna L. Gaucher disease protects against tuberculosis. Proc Natl Acad Sci USA. 2023;120(7):e2217673120 doi:10.1073/pnas.2217673120.

Ubiquitylation of BBSome is required for ciliary assembly and signaling

Authors:
Chiuso F, Delle Donne R, Giamundo G, Rinaldi L, Borzacchiello D, Moraca F, Intartaglia D, Iannucci R, Senatore E, Lignitto L, Garbi C, Conflitti P, Catalanotti B, Conte I, Feliciello A
Citation:
Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep. 2023 Feb 6:e55571. doi:10.15252/embr.202255571. Online ahead of print
Epub:
Yes
Abstract:
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, renal abnormalities, postaxial...
Link:
https://www.embopress.org/doi/full/10.15252/embr.202255571
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka fish)
Citation Extract:
Chiuso F, Delle Donne R, Giamundo G, Rinaldi L, Borzacchiello D, Moraca F, Intartaglia D, Iannucci R, Senatore E, Lignitto L, Garbi C, Conflitti P, Catalanotti B, Conte I, Feliciello A. Ubiquitylation of BBSome is required for ciliary assembly and signaling. Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep. 2023 Feb 6:e55571. doi:10.15252/embr.202255571. Online ahead of print.

Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs

Authors:
Klämbt V, Buerger F, Wang C, Naert T, Richter K, Nauth T, Weiss AC, Sieckmann T, Lai E, Connaughton D, Seltzsam S, Mann N, Majmundar A, Wu CH, Onuchic-Whitford A, Shril S, Schneider S, Schierbaum L, Dai R, Bekheirnia MR, Joosten M, Shlomovitz O, Vivante A, Banne E, Mane S, Lifton RP, Kirschner K, Kispert A, Rosenberger G, Fischer KD, Lienkamp S, Zegers M, Hildebrandt F
Citation:
J Am Soc Nephrol. 2022 Nov 22:ASN.2022010050. doi: 10.1681/ASN.2022010050. Online ahead of print
Epub:
Yes
Abstract:
Background About 40 disease genes have been described to date for isolated congenital anomalies of the kidneys and urinary...
Link:
https://journals.lww.com/jasn/Abstract/2023/02000/Genetic_Variants_in_ARHGEF6_Cause_Congenital.14.aspx
Organism or Cell Type:
Xenopus
Citation Extract:
Klämbt V, Buerger F, Wang C, Naert T, Richter K, Nauth T, Weiss AC, Sieckmann T, Lai E, Connaughton D, Seltzsam S, Mann N, Majmundar A, Wu CH, Onuchic-Whitford A, Shril S, Schneider S, Schierbaum L, Dai R, Bekheirnia MR, Joosten M, Shlomovitz O, Vivante A, Banne E, Mane S, Lifton RP, Kirschner K, Kispert A, Rosenberger G, Fischer KD, Lienkamp S, Zegers M, Hildebrandt F . Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. J Am Soc Nephrol. 2022 Nov 22:ASN.2022010050. doi: 10.1681/ASN.2022010050. Online ahead of print.

Confined environments induce polarized paraspeckle condensates

Authors:
Todorovski V, McCluggage F, Li Y, Meid A, Spatz JP, Holle AW, Fox AH, Choi Y
Citation:
Commun Biol 6, 145 (2023). doi:10.1038/s42003-023-04528-4
Epub:
Not Epub
Abstract:
Cancer cells experience confinement as they navigate the tumour microenvironment during metastasis. Recent studies have...
Link:
https://www.nature.com/articles/s42003-023-04528-4
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: MDA-MB-231 human breast cancer cells
Citation Extract:
Todorovski V, McCluggage F, Li Y, Meid A, Spatz JP, Holle AW, Fox AH, Choi Y. Confined environments induce polarized paraspeckle condensates. Commun Biol 6, 145 (2023). doi:10.1038/s42003-023-04528-4.

Tmem88 confines ectodermal Wnt2bb signaling in pharyngeal arch artery progenitors for balancing cell cycle progression and cell fate decision

Authors:
Zhang M, Liu J, Mao A, Ning G, Cao Y, Zhang W, Wang Q
Citation:
Nat Cardiovasc Res. 2023;[epub] doi:10.1038/s44161-023-00215-z
Epub:
Not Epub
Abstract:
Pharyngeal arch artery (PAA) progenitors undergo proliferative expansion and angioblast differentiation to build vessels...
Link:
https://www.nature.com/articles/s44161-023-00215-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang M, Liu J, Mao A, Ning G, Cao Y, Zhang W, Wang Q. Tmem88 confines ectodermal Wnt2bb signaling in pharyngeal arch artery progenitors for balancing cell cycle progression and cell fate decision. Nat Cardiovasc Res. 2023;[epub] doi:10.1038/s44161-023-00215-z.

DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration

Authors:
Aslesh T, Erkut E, Ren J, Lim KRQ, Woo S, Hatlevig S, Moulton HM, Gosgnach S, Greer J, Maruyama R, Yokota T
Citation:
JCI Insight. 2023;8(5):e160516. doi: 10.1172/jci.insight.160516. Online ahead of print
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO)-mediated therapy is a promising strategy to treat several neurological diseases including spinal...
Link:
https://insight.jci.org/articles/view/160516
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Aslesh T, Erkut E, Ren J, Lim KRQ, Woo S, Hatlevig S, Moulton HM, Gosgnach S, Greer J, Maruyama R, Yokota T. DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration. JCI Insight. 2023;8(5):e160516. doi: 10.1172/jci.insight.160516. Online ahead of print.

RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation

Authors:
Wu D, Dean J
Citation:
Cell Rep. 2023;42(2):112407. doi:10.1016/j.celrep.2023.112047
Epub:
Not Epub
Abstract:
Mammalian development is precisely controlled by cell differentiation. Identifying new regulators and investigating their...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00058-X
Delivery Method:
microinjection
Organism or Cell Type:
mouse embryo
Citation Extract:
Wu D, Dean J. RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation. Cell Rep. 2023;42(2):112407. doi:10.1016/j.celrep.2023.112047.

The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs

Authors:
Herchenröther A, Gossen S, Friedrich T, Reim A, Daus N, Diegmüller F, Leers J, Sani HM, Gerstner S, Schwarz L, Stellmacher I, Szymkowiak LV, Nist A, Stiewe T, Borggrefe T, Mann M, Mackay JP, Bartkuhn M, Borchers A, Lan J, Hake SB
Citation:
Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x
Epub:
Not Epub
Abstract:
Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A...
Link:
https://www.nature.com/articles/s41467-023-36114-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Herchenröther A, Gossen S, Friedrich T, Reim A, Daus N, Diegmüller F, Leers J, Sani HM, Gerstner S, Schwarz L, Stellmacher I, Szymkowiak LV, Nist A, Stiewe T, Borggrefe T, Mann M, Mackay JP, Bartkuhn M, Borchers A, Lan J, Hake SB. The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x.

The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity

Authors:
Shen X, Zhi F, Shi C, Xu J, Chao Y, Xu J, Bai Y, Jiang Y, Yang B
Citation:
J Transl Med. 2023 Jan 28;21(1):52. doi: 10.1186/s12967-023-03895-0
Epub:
Not Epub
Abstract:
Background/aims: Arsenic trioxide (ATO) is the first-line therapeutic drug for acute promyelocytic leukemia. However, the...
Link:
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-03895-0
Delivery Method:
X-tremeGENE siRNA Transfection Reagent
Organism or Cell Type:
cell culture: neonatal mouse cardiomyocytes
Citation Extract:
Shen X, Zhi F, Shi C, Xu J, Chao Y, Xu J, Bai Y, Jiang Y, Yang B. The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity. J Transl Med. 2023 Jan 28;21(1):52. doi: 10.1186/s12967-023-03895-0.

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