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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Hnf1b renal expression directed by a distal enhancer responsive to Pax8

Authors:
Goea L, Buisson I, Bello V, Eschstruth A, Paces-Fessy M, Le Bouffant R, Chesneau A, Cereghini S, Riou JF, Umbhauer M
Citation:
Sci Rep. 2022 Nov 19;12(1):19921. doi: 10.1038/s41598-022-21171-x
Epub:
Not Epub
Abstract:
Xenopus provides a simple and efficient model system to study nephrogenesis and explore the mechanisms causing renal...
Link:
https://www.nature.com/articles/s41598-022-21171-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Goea L, Buisson I, Bello V, Eschstruth A, Paces-Fessy M, Le Bouffant R, Chesneau A, Cereghini S, Riou JF, Umbhauer M. Hnf1b renal expression directed by a distal enhancer responsive to Pax8. Sci Rep. 2022 Nov 19;12(1):19921. doi: 10.1038/s41598-022-21171-x.

Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells

Authors:
Zhu P, Zheng P, Kong X, Wang S, Cao M, Zhao C
Citation:
EMBO Rep. 2022 Nov 21:e54984. doi: 10.15252/embr.202254984. Online ahead of print
Epub:
Not Epub
Abstract:
Spinal cord injury (SCI) can cause long-lasting disability in mammals due to the lack of axonal regrowth together with the...
Link:
https://www.embopress.org/doi/full/10.15252/embr.202254984
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Zhu P, Zheng P, Kong X, Wang S, Cao M, Zhao C. Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells. EMBO Rep. 2022 Nov 21:e54984. doi: 10.15252/embr.202254984. Online ahead of print.

The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection

Authors:
Liang H, Li Y, Li M, Zhou W, Chen J, Zhang Z, Yang Y, Ran C, Zhou Z
Citation:
Front Immunol. 2022 Nov 3;13:1031962. doi: 10.3389/fimmu.2022.1031962. eCollection 2022
Epub:
Not Epub
Abstract:
β-glucan has been used as immunostimulant for fish. However, the effect of yeast β-glucan on viral infections has been less...
Link:
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031962/full
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Liang H, Li Y, Li M, Zhou W, Chen J, Zhang Z, Yang Y, Ran C, Zhou Z. The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Front Immunol. 2022 Nov 3;13:1031962. doi: 10.3389/fimmu.2022.1031962. eCollection 2022.

Developing Therapeutic Splice-Correcting Antisense Oligomers for Adult-Onset Pompe Disease with c.-32-13T>G Mutation

Authors:
Ham KA, Johnsen RD, Tchan M, Wilton SD, Aung-Htut MT
Citation:
Methods Mol Biol. 2023;2587:239-251. doi: 10.1007/978-1-0716-2772-3_14
Epub:
Not Epub
Abstract:
The mutation c.-32-13T>G in the GAA gene impacts normal exon 2 splicing and is found in two-thirds of late-onset Pompe...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_14
Organism or Cell Type:
cell culture: fibroblast, forced-myogenic cells
Citation Extract:
Ham KA, Johnsen RD, Tchan M, Wilton SD, Aung-Htut MT. Developing Therapeutic Splice-Correcting Antisense Oligomers for Adult-Onset Pompe Disease with c.-32-13T>G Mutation. Methods Mol Biol. 2023;2587:239-251. doi: 10.1007/978-1-0716-2772-3_14.

Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy

Authors:
Stoodley J, Miraz DS, Jad Y, Fischer M, Wood MJA, Varela MA
Citation:
Methods Mol Biol. 2023;2587:209-237. doi: 10.1007/978-1-0716-2772-3_13
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (ASOs) have shown great therapeutic potential in the treatment of many neuromuscular diseases...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_13
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Stoodley J, Miraz DS, Jad Y, Fischer M, Wood MJA, Varela MA. Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy. Methods Mol Biol. 2023;2587:209-237. doi: 10.1007/978-1-0716-2772-3_13.

Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR

Authors:
Anwar S, Yokota T
Citation:
Immunoblotting, and Membrane Wounding Assay. Methods Mol Biol. 2023;2587:183-196. doi: 10.1007/978-1-0716-2772-3_11
Epub:
Not Epub
Abstract:
Dysferlinopathies are a group of disabling muscular dystrophies that includes limb girdle muscular dystrophy type 2B (LGMD2B),...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_11
Citation Extract:
Anwar S, Yokota T. Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR. Immunoblotting, and Membrane Wounding Assay. Methods Mol Biol. 2023;2587:183-196. doi: 10.1007/978-1-0716-2772-3_11.

Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes

Authors:
Echigoya Y, Yokota T
Citation:
Methods Mol Biol. 2023;2587:125-139. doi: 10.1007/978-1-0716-2772-3_7
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomer (PMO)-mediated exon skipping is a therapeutic approach that applies to many Duchenne...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_7
Organism or Cell Type:
cell culture: myotubes
Citation Extract:
Echigoya Y, Yokota T. Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes. Methods Mol Biol. 2023;2587:125-139. doi: 10.1007/978-1-0716-2772-3_7.

Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs

Authors:
Shah MNA, Yokota T
Citation:
Methods Mol Biol. 2023;2587:107-124. doi: 10.1007/978-1-0716-2772-3_6
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is caused by the mutations in the DMD gene resulting in no dystrophin production. Skipping...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_6
Organism or Cell Type:
Canis familiaris (dog) CXMDj
Citation Extract:
Shah MNA, Yokota T. Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs. Methods Mol Biol. 2023;2587:107-124. doi: 10.1007/978-1-0716-2772-3_6.

Viltolarsen: From Preclinical Studies to FDA Approval

Authors:
Roshmi RR, Yokota T
Citation:
Methods Mol Biol. 2023;2587:31-41. doi: 10.1007/978-1-0716-2772-3_2
Epub:
Not Epub
Abstract:
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide (PMO) designed to skip exon 53 of the DMD gene for the...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_2
Citation Extract:
Roshmi RR, Yokota T. Viltolarsen: From Preclinical Studies to FDA Approval. Methods Mol Biol. 2023;2587:31-41. doi: 10.1007/978-1-0716-2772-3_2.

DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1

Authors:
Findlay AR, Paing MM, Daw JA, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Weihl CC
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.17.516920
Epub:
Not Epub
Abstract:
Dominant missense mutations in DNAJB6, an HSP40 co-chaperone, cause limb girdle muscular dystrophy (LGMD) D1. No treatments are...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.17.516920v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: mouse myotubes & human myotubes, mice
Citation Extract:
Findlay AR, Paing MM, Daw JA, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Weihl CC. DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.17.516920.

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