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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII

Authors:
Elnaggar M, Al-Mohannadi A, Hasan W, Abdelrahman D, Al-Kubaisi MJ, Pavlovski I, Gentilcore G, Sathappan A, Kizhakayil D, Ali AI, Mohan S, Olagunju D, Cugno C, Grivel JC, Borsotti C, Follenzi A, Da'as SI, Deola S
Citation:
Blood Adv. 2023 Mar 14;7(5):697-711. doi: 10.1182/bloodadvances.2022009014. PMID: 36477543; PMCID: PMC9984962
Epub:
Not Epub
Abstract:
Emerging gene therapy clinical trials test the correction of hemophilia A (HA) by replacing factor VIII (FVIII) in autologous...
Link:
https://ashpublications.org/bloodadvances/article/7/5/697/493421/CD14-CD31-monocytes-expanded-by-UM171-correct
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Elnaggar M, Al-Mohannadi A, Hasan W, Abdelrahman D, Al-Kubaisi MJ, Pavlovski I, Gentilcore G, Sathappan A, Kizhakayil D, Ali AI, Mohan S, Olagunju D, Cugno C, Grivel JC, Borsotti C, Follenzi A, Da'as SI, Deola S. CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII. Blood Adv. 2023 Mar 14;7(5):697-711. doi: 10.1182/bloodadvances.2022009014. PMID: 36477543; PMCID: PMC9984962.

Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration

Authors:
Mitra S, Devi S, Lee M-S, Goldman D
Citation:
Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211690119. doi: 10.1073/pnas.2211690119. Epub 2022 Dec 5
Epub:
Not Epub
Abstract:
In the zebrafish retina, Müller glia (MG) can regenerate retinal neurons lost to injury or disease. Even though zebrafish MG...
Link:
https://www.pnas.org/doi/10.1073/pnas.2211690119
Delivery Method:
injection
Organism or Cell Type:
zebrafish
Citation Extract:
Mitra S, Devi S, Lee M-S, Goldman D. Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211690119. doi: 10.1073/pnas.2211690119. Epub 2022 Dec 5.

Human SLFN5 and its Xenopus Laevis ortholog regulate entry into mitosis and oocyte meiotic resumption

Authors:
Vit G, Hirth A, Neugebauer N, Kraft BN, Sigismondo G, Cazzola A, Tessmer C, Duro J, Krijgsveld J, Hofmann I, Berger M, Klüter H, Niehrs C, Nilsson J, Krämer A
Citation:
Cell Death Discov. 2022;8(1):484. doi:10.1038/s41420-022-01274-0
Epub:
Not Epub
Abstract:
The Schlafen gene family was first described in mice as a regulator of thymocyte development. Further studies showed...
Link:
https://www.nature.com/articles/s41420-022-01274-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Vit G, Hirth A, Neugebauer N, Kraft BN, Sigismondo G, Cazzola A, Tessmer C, Duro J, Krijgsveld J, Hofmann I, Berger M, Klüter H, Niehrs C, Nilsson J, Krämer A. Human SLFN5 and its Xenopus Laevis ortholog regulate entry into mitosis and oocyte meiotic resumption. Cell Death Discov. 2022;8(1):484. doi:10.1038/s41420-022-01274-0.

Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition

Authors:
Piacentino ML, Hutchins EJ, Andrews CJ, Bronner ME
Citation:
Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2212879119. doi: 10.1073/pnas.2212879119. Epub 2022 Dec 12
Epub:
Not Epub
Abstract:
Epithelial-to-mesenchymal transition (EMT) is a dramatic change in cellular physiology during development and metastasis, which...
Link:
https://www.pnas.org/doi/10.1073/pnas.2212879119
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Piacentino ML, Hutchins EJ, Andrews CJ, Bronner ME. Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2212879119. doi: 10.1073/pnas.2212879119. Epub 2022 Dec 12.

Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia

Authors:
Kwon KY, Jeong H, Jang DG, Kwon T, Park TJ
Citation:
Genes Genomics. 2022 Dec 12. doi: 10.1007/s13258-022-01350-w. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Motile cilia in a vertebrate are important to sustaining activities of life. Fluid flow on the apical surface of...
Link:
https://link.springer.com/article/10.1007/s13258-022-01350-w
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kwon KY, Jeong H, Jang DG, Kwon T, Park TJ. Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia. Genes Genomics. 2022 Dec 12. doi: 10.1007/s13258-022-01350-w. Online ahead of print.

Loxhd1b inhibits the hair cell development in zebrafish: Possible relation to the BDNF/TrkB/ERK pathway

Authors:
Liu J, Zhang X, Zhang Q, Wang R, Ma J, Bai X, Wang D
Citation:
Front Cell Neurosci. 2022 Nov 24;16:1065309. doi: 10.3389/fncel.2022.1065309. eCollection 2022
Epub:
Not Epub
Abstract:
Background: Mutations in lipoxygenase homology domain 1 (LOXHD1) cause autosomal recessive inheritance, leading to high-...
Link:
https://www.frontiersin.org/articles/10.3389/fncel.2022.1065309/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu J, Zhang X, Zhang Q, Wang R, Ma J, Bai X, Wang D. Loxhd1b inhibits the hair cell development in zebrafish: Possible relation to the BDNF/TrkB/ERK pathway. Front Cell Neurosci. 2022 Nov 24;16:1065309. doi: 10.3389/fncel.2022.1065309. eCollection 2022.

ftr82 is necessary for hair cell morphogenesis and auditory function during zebrafish development

Authors:
Yin G, Qian F, Yao J, Wang Z, Wang X, Liu D, Wang C
Citation:
J Genet Genomics. 2022 Dec 1:S1673-8527(22)00252-1. doi: 10.1016/j.jgg.2022.11.008. Online ahead of print
Epub:
Yes
Abstract:
Damages of sensory hair cells (HCs) are mainly responsible for sensorineural hearing loss, while the pathological mechanism...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1673852722002521
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yin G, Qian F, Yao J, Wang Z, Wang X, Liu D, Wang C. ftr82 is necessary for hair cell morphogenesis and auditory function during zebrafish development. J Genet Genomics. 2022 Dec 1:S1673-8527(22)00252-1. doi: 10.1016/j.jgg.2022.11.008. Online ahead of print.

PPMOs: A Case Study for Cell-Penetrating Peptide Application

Authors:
Bittner S, Moulton ZX, Moulton HM
Citation:
In Cell-Penetrating Peptides (eds M. Oba and Y. Demizu). 2023:ch 15. doi:10.1002/9783527835997.ch15
Epub:
Not Epub
Abstract:
The current state of the art for in vivo antisense morpholino technology is peptide-conjugated phosphorodiamidate morpholino...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/9783527835997.ch15
Delivery Method:
peptide-linked
Citation Extract:
Bittner S, Moulton ZX, Moulton HM. PPMOs: A Case Study for Cell-Penetrating Peptide Application. In Cell-Penetrating Peptides (eds M. Oba and Y. Demizu). 2023:ch 15. doi:10.1002/9783527835997.ch15.

LOF variants identifying candidate genes of laterality defects patients with congenital heart disease

Authors:
Liu S, Wei W, Wang P, Liu C, Jiang X, Li T, Li F, Wu Y, Chen S, Sun K, Xu R
Citation:
PLoS Genet. 2022;18(12):e1010530. doi:10.1371/journal.pgen.1010530
Epub:
Not Epub
Abstract:
Defects in laterality pattern can result in abnormal positioning of the internal organs during the early stages of...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010530
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu S, Wei W, Wang P, Liu C, Jiang X, Li T, Li F, Wu Y, Chen S, Sun K, Xu R. LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. PLoS Genet. 2022;18(12):e1010530. doi:10.1371/journal.pgen.1010530.

Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates

Authors:
Faustini G, Longhena F, Muscò A, Bono F, Parrella E, La Via L, Barbon A, Pizzi M, Onofri F, Benfenati F, Missale C, Memo M, Zizioli D, Bellucci A
Citation:
Cells. 2022; 11(23):3902. doi:10.3390/cells11233902
Epub:
Not Epub
Abstract:
.Attention deficit and hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by alterations in the...
Link:
https://www.mdpi.com/2073-4409/11/23/3902
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Faustini G, Longhena F, Muscò A, Bono F, Parrella E, La Via L, Barbon A, Pizzi M, Onofri F, Benfenati F, Missale C, Memo M, Zizioli D, Bellucci A. Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates. Cells. 2022; 11(23):3902. doi:10.3390/cells11233902.

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