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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

The development of shape. Modular control of growth in the lepidopteran forewing

Authors:
McKenna KZ, Nijhout HF
Citation:
J Exp Zool B Mol Dev Evol. 2021 Oct 28. doi:10.1002/jez.b.23101. Online ahead of print
Epub:
Yes
Abstract:
The mechanisms by which tissues and organs achieve their final size and shape during development are largely unknown. Although...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/jez.b.23101
Organism or Cell Type:
Junonia coenia (butterfly)
Citation Extract:
McKenna KZ, Nijhout HF. The development of shape. Modular control of growth in the lepidopteran forewing. J Exp Zool B Mol Dev Evol. 2021 Oct 28. doi:10.1002/jez.b.23101. Online ahead of print.

Multifunctional Nanopolymers for Blood-Brain Barrier Delivery and Inhibition of Glioblastoma Growth through EGFR/EGFRvIII, c-Myc, and PD-1

Authors:
Patil R, Sun T, Rashid MH, Israel LL, Ramesh A, Davani S, Black KL, Ljubimov AV, Holler E, Ljubimova JY
Citation:
Nanomaterials. 2021;11(11):2892. doi:10.3390/nano11112892
Epub:
Not Epub
Abstract:
Glioblastoma (GBM) is the most prevalent primary brain cancer in the pediatric and adult population. It is known as an...
Link:
https://www.mdpi.com/2079-4991/11/11/2892
Delivery Method:
nanoparticle
Organism or Cell Type:
Xenograft GL261 (mouse glioblastoma) in mice
Citation Extract:
Patil R, Sun T, Rashid MH, Israel LL, Ramesh A, Davani S, Black KL, Ljubimov AV, Holler E, Ljubimova JY. Multifunctional Nanopolymers for Blood-Brain Barrier Delivery and Inhibition of Glioblastoma Growth through EGFR/EGFRvIII, c-Myc, and PD-1. Nanomaterials. 2021;11(11):2892. doi:10.3390/nano11112892.

Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction

Authors:
Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A
Citation:
J Am Chem Soc. 2021 Oct 27. doi: 10.1021/jacs.1c08723. Online ahead of print
Epub:
Not Epub
Abstract:
Conditionally activated, caged morpholino antisense agents (cMOs) are tools that enable the temporal and spatial investigation...
Link:
https://pubs.acs.org/doi/10.1021/jacs.1c08723
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A. Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction. J Am Chem Soc. 2021 Oct 27. doi: 10.1021/jacs.1c08723. Online ahead of print.

Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis

Authors:
Zhang F, Zeng QY, Xu H, Xu AN, Liu DJ, Li NZ, Chen Y, Jin Y, Xu CH, Feng CZ, Zhang YL, Liu D, Liu N, Xie YY, Yu SH, Yuan H, Xue K, Shi JY, Liu TX, Xu PF, Zhao WL, Zhou Y, Wang L, Huang QH, Chen Z, Chen SJ, Zhou XL, Sun XJ
Citation:
Cell Discov. 2021 Oct 26;7(1):98. doi: 10.1038/s41421-021-00332-8
Epub:
Not Epub
Abstract:
The amino acid response (AAR) and unfolded protein response (UPR) pathways converge on eIF2α phosphorylation, which is...
Link:
https://www.nature.com/articles/s41421-021-00332-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Zeng QY, Xu H, Xu AN, Liu DJ, Li NZ, Chen Y, Jin Y, Xu CH, Feng CZ, Zhang YL, Liu D, Liu N, Xie YY, Yu SH, Yuan H, Xue K, Shi JY, Liu TX, Xu PF, Zhao WL, Zhou Y, Wang L, Huang QH, Chen Z, Chen SJ, Zhou XL, Sun XJ. Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell Discov. 2021 Oct 26;7(1):98. doi: 10.1038/s41421-021-00332-8.

Renadirsen, a Novel 2'OMeRNA/ENA® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo

Authors:
Ito K, Takakusa H, Kakuta M, Kanda A, Takagi N, Nagase H, Watanabe N, Asano D, Goda R, Masuda T, Nakamura A, Onishi Y, Onoda T, Koizumi M, Takeshima Y, Matsuo M, Takaishi K
Citation:
Curr Issues Mol Biol. 2021 Sep 25;43(3):1267-1281. doi: 10.3390/cimb43030090
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by out-of-frame or nonsense mutation in the...
Link:
https://www.mdpi.com/1467-3045/43/3/90/htm
Delivery Method:
injection
Organism or Cell Type:
mice
Citation Extract:
Ito K, Takakusa H, Kakuta M, Kanda A, Takagi N, Nagase H, Watanabe N, Asano D, Goda R, Masuda T, Nakamura A, Onishi Y, Onoda T, Koizumi M, Takeshima Y, Matsuo M, Takaishi K. Renadirsen, a Novel 2'OMeRNA/ENA® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo. Curr Issues Mol Biol. 2021 Sep 25;43(3):1267-1281. doi: 10.3390/cimb43030090.

The Ribosome Biogenesis Factor Ltv1 Is Essential for Digestive Organ Development and Definitive Hematopoiesis in Zebrafish

Authors:
Zhang C, Huang R, Ma X, Chen J, Han X, Li L, Luo L, Ruan H, Huang H
Citation:
Front Cell Dev Biol. 2021 Oct 7;9:704730. doi: 10.3389/fcell.2021.704730. eCollection 2021
Epub:
Not Epub
Abstract:
Ribosome biogenesis is a fundamental activity in cells. Ribosomal dysfunction underlies a category of diseases called...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2021.704730/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang C, Huang R, Ma X, Chen J, Han X, Li L, Luo L, Ruan H, Huang H. The Ribosome Biogenesis Factor Ltv1 Is Essential for Digestive Organ Development and Definitive Hematopoiesis in Zebrafish. Front Cell Dev Biol. 2021 Oct 7;9:704730. doi: 10.3389/fcell.2021.704730. eCollection 2021.

IPIP27A cooperates with OCRL to support endocytic traffic in the zebrafish pronephric tubule

Authors:
Oltrabella F, Jackson-Crawford A, Yan G, Rixham S, Starborg T, Lowe M
Citation:
Hum Molec Genet. 2021;ddab307 [Epub] doi:10.1093/hmg/ddab307
Epub:
Yes
Abstract:
Endocytosis is a fundamentally important process through which material is internalized into cells from the extracellular...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddab307/6406900
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oltrabella F, Jackson-Crawford A, Yan G, Rixham S, Starborg T, Lowe M. IPIP27A cooperates with OCRL to support endocytic traffic in the zebrafish pronephric tubule. Hum Molec Genet. 2021;ddab307 [Epub] doi:10.1093/hmg/ddab307.

A dual involvement of Protocadherin-18a in stromal cell development guides the formation of a functional hematopoietic niche

Authors:
Touret A-L, Vivier C, Schmidt A, Herbomel P, Murayama E
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.19.465038
Epub:
Not Epub
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) emerge from the aorta and migrate to the caudal hematopoietic tissue (CHT) of...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.19.465038v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Touret A-L, Vivier C, Schmidt A, Herbomel P, Murayama E. A dual involvement of Protocadherin-18a in stromal cell development guides the formation of a functional hematopoietic niche. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.19.465038 .

Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA

Authors:
Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD
Citation:
Nucl Acids Res. 2021;[Epub]:gkab896. doi:10.1093/nar/gkab896
Epub:
Yes
Abstract:
Eukaryotic cells recognize intracellular pathogens through pattern recognition receptors, including sensors of aberrant nucleic...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab896/6406474
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: A549
Citation Extract:
Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD. Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA. Nucl Acids Res. 2021;[Epub]:gkab896. doi:10.1093/nar/gkab896.

Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice

Authors:
Mukashyaka MC, Wu CL, Ha K, Zhang J, Wood J, Foley S, Mastis B, Jungels N, Sun H, Shadid M, Harriman S, Hadcock JR
Citation:
Pharm Res. 2021 Oct 20. doi: 10.1007/s11095-021-03118-5. Online ahead of print
Epub:
Yes
Abstract:
Purpose: Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) have shown promise in treating Duchenne muscular...
Link:
https://link.springer.com/article/10.1007%2Fs11095-021-03118-5
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Mukashyaka MC, Wu CL, Ha K, Zhang J, Wood J, Foley S, Mastis B, Jungels N, Sun H, Shadid M, Harriman S, Hadcock JR. Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice. Pharm Res. 2021 Oct 20. doi: 10.1007/s11095-021-03118-5. Online ahead of print.

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