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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing

Authors:
Biswas K, Couillard M, Cavallone L, Burkett S, Stauffer S, Martin BK, Southon E, Reid S, Plona TM, Baugher RN, Mellott SD, Pike KM, Albaugh ME, Maedler-Kron C, Hamel N, Tessarollo L, Marcus V, Foulkes WD, Sharan SK
Citation:
Cell Death Dis. 2021 Sep 6;12(9):838. doi: 10.1038/s41419-021-04130-8
Epub:
Not Epub
Abstract:
Hereditary non-polyposis colorectal cancer, now known as Lynch syndrome (LS) is one of the most common cancer predisposition...
Link:
https://www.nature.com/articles/s41419-021-04130-8
Delivery Method:
electroporation, Vivo-Morpholino
Organism or Cell Type:
cell culture: human and murine fibroblasts, mice
Citation Extract:
Biswas K, Couillard M, Cavallone L, Burkett S, Stauffer S, Martin BK, Southon E, Reid S, Plona TM, Baugher RN, Mellott SD, Pike KM, Albaugh ME, Maedler-Kron C, Hamel N, Tessarollo L, Marcus V, Foulkes WD, Sharan SK. A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing. Cell Death Dis. 2021 Sep 6;12(9):838. doi: 10.1038/s41419-021-04130-8.

Function of chromatin modifier Hmgn1 during neural crest and craniofacial development

Authors:
Ihewulezi C, Saint-Jeannet JP
Citation:
Genesis. 2021 Sep 3:e23447. doi: 10.1002/dvg.23447. Online ahead of print
Epub:
Yes
Abstract:
The neural crest is a dynamic embryonic structure that plays a major role in the formation of the vertebrate craniofacial...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/dvg.23447
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Ihewulezi C, Saint-Jeannet JP. Function of chromatin modifier Hmgn1 during neural crest and craniofacial development. Genesis. 2021 Sep 3:e23447. doi: 10.1002/dvg.23447. Online ahead of print.

Adar-mediated A-to-I editing is required for establishment of embryonic body axes in zebrafish

Authors:
Niescierowicz K, Pryszcz L, Navarrete C, Tralle E, Kasprzyk ME, Nahia KA, Misztal K, Bochtler M, Winata C
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.26.457081
Epub:
Not Epub
Abstract:
Adenosine deaminases (ADARs) catalyze the deamination of adenosine to inosine, also known as A-to-I editing, in RNA. Although A...
Link:
https://www.biorxiv.org/content/10.1101/2021.08.26.457081v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Niescierowicz K, Pryszcz L, Navarrete C, Tralle E, Kasprzyk ME, Nahia KA, Misztal K, Bochtler M, Winata C. Adar-mediated A-to-I editing is required for establishment of embryonic body axes in zebrafish. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.26.457081.

Loss of nucleoporin Nup50 is a risk factor for amyotrophic lateral sclerosis

Authors:
Megat S, Mora N, Sanogo J, Catanese A, Alami NO, Freischmidt A, Mingaj X, de Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, van Eijk KR, Veldink JH, Project Mine ALS sequencing consortium, Lautrette G, Couratier P, Boeckers T, Albert C. Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L
Citation:
medRxiv. 2021;[preprint] doi:10.1101/2021.08.23.21262299
Epub:
Not Epub
Abstract:
The genetic basis of amyotrophic lateral sclerosis (ALS) is still incompletely understood. Using two independent genetic...
Link:
https://www.medrxiv.org/content/10.1101/2021.08.23.21262299v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Megat S, Mora N, Sanogo J, Catanese A, Alami NO, Freischmidt A, Mingaj X, de Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, van Eijk KR, Veldink JH, Project Mine ALS sequencing consortium, Lautrette G, Couratier P, Boeckers T, Albert C. Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L. Loss of nucleoporin Nup50 is a risk factor for amyotrophic lateral sclerosis. medRxiv. 2021;[preprint] doi:10.1101/2021.08.23.21262299 .

Neutrophil-associated responses to Vibrio cholerae infection in a natural host model

Authors:
Farr D, Nag D, Chazin WJ, Harrison S, Thummel R, Luo X, Raychaudhuri S, Withey JH
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.24.457598
Epub:
Not Epub
Abstract:
Vibrio cholerae, the cause of human cholera, is an aquatic bacterium found in association with a variety of animals in the...
Link:
https://www.biorxiv.org/content/10.1101/2021.08.24.457598v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Farr D, Nag D, Chazin WJ, Harrison S, Thummel R, Luo X, Raychaudhuri S, Withey JH. Neutrophil-associated responses to Vibrio cholerae infection in a natural host model. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.24.457598.

Foxm1 regulates neural progenitor fate during spinal cord regeneration

Authors:
Pelzer D, Phipps LS, Thuret R, Gallardo-Dodd CJ, Baker SM, Dorey K
Citation:
EMBO Rep. 2021:e50932. doi:10.15252/embr.202050932. Online ahead of print
Epub:
Yes
Abstract:
Xenopus tadpoles have the ability to regenerate their tails upon amputation. Although some of the molecular and cellular...
Link:
https://www.embopress.org/doi/full/10.15252/embr.202050932
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Pelzer D, Phipps LS, Thuret R, Gallardo-Dodd CJ, Baker SM, Dorey K. Foxm1 regulates neural progenitor fate during spinal cord regeneration. EMBO Rep. 2021:e50932. doi:10.15252/embr.202050932. Online ahead of print.

The effect of absent blood flow on the zebrafish cerebral and trunk vasculature

Authors:
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T, Armitage P
Citation:
Vascular Biol. 2021;(3)1:1-16. doi:10.1530/VB-21-0009
Epub:
Not Epub
Abstract:
The role of blood flow in vascular development is complex and context-dependent. In this study, we quantify the effect of the...
Link:
https://vb.bioscientifica.com/view/journals/vb/3/1/VB-21-0009.xml
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T, Armitage P. The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. Vascular Biol. 2021;(3)1:1-16. doi:10.1530/VB-21-0009.

Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication

Authors:
Li Y, Garcia G Jr, Arumugaswami V, Guo F
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.23.457434
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (ASOs) are an emerging class of drugs that target RNAs. Current ASO designs strictly follow the rule...
Link:
https://www.biorxiv.org/content/10.1101/2021.08.23.457434v1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HEK293-hACE2
Citation Extract:
Li Y, Garcia G Jr, Arumugaswami V, Guo F. Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.23.457434.

Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting

Authors:
Watterston C, Halabi R, McFarlane S, Childs SJ
Citation:
PLoS Genet. 2021;17(8):e1009769. doi:10.1371/journal.pgen.1009769
Epub:
Not Epub
Abstract:
Vessel growth integrates diverse extrinsic signals with intrinsic signaling cascades to coordinate cell migration and sprouting...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009769
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Watterston C, Halabi R, McFarlane S, Childs SJ. Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting. PLoS Genet. 2021;17(8):e1009769. doi:10.1371/journal.pgen.1009769.

N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Authors:
Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C, Zhou Y
Citation:
Mol Cancer. 2021 Aug 20;20(1):105. doi: 10.1186/s12943-021-01398-4
Epub:
Not Epub
Abstract:
Background: An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable...
Link:
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-021-01398-4
Organism or Cell Type:
cell culture: A549 and SW900
Citation Extract:
Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C, Zhou Y. N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 2021 Aug 20;20(1):105. doi: 10.1186/s12943-021-01398-4.

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