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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression

Authors:
Franke M, De la Calle-Mustienes E, Neto A, Almuedo-Castillo M, Irastorza-Azcarate I, Acemel RD, Tena JJ, Santos-Pereira JM, Gómez-Skarmeta JL
Citation:
Nat Commun. 2021 Sep 13;12(1):5415. doi: 10.1038/s41467-021-25604-5
Epub:
Not Epub
Abstract:
Coordinated chromatin interactions between enhancers and promoters are critical for gene regulation. The architectural protein...
Link:
https://www.nature.com/articles/s41467-021-25604-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Franke M, De la Calle-Mustienes E, Neto A, Almuedo-Castillo M, Irastorza-Azcarate I, Acemel RD, Tena JJ, Santos-Pereira JM, Gómez-Skarmeta JL. CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression. Nat Commun. 2021 Sep 13;12(1):5415. doi: 10.1038/s41467-021-25604-5.

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa

Authors:
Tucker BA, Burnight ER, Cranston CM, Ulferts MJ, Luse MA, Westfall T, Scott CA, Marsden A, Gibson-Corley K, Wiley LA, Han IC, Slusarski DC, Mullins RF, Stone EM
Citation:
Gene Ther. 2021 Sep 14. doi: 10.1038/s41434-021-00291-5. Online ahead of print
Epub:
Yes
Abstract:
By combining next generation whole exome sequencing and induced pluripotent stem cell (iPSC) technology we found that an Alu...
Link:
https://www.nature.com/articles/s41434-021-00291-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tucker BA, Burnight ER, Cranston CM, Ulferts MJ, Luse MA, Westfall T, Scott CA, Marsden A, Gibson-Corley K, Wiley LA, Han IC, Slusarski DC, Mullins RF, Stone EM. Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Gene Ther. 2021 Sep 14. doi: 10.1038/s41434-021-00291-5. Online ahead of print.

N-myc Downstream Regulated Gene 1 (NDRG1) functions as a molecular switch for cellular adaptation to hypoxia

Authors:
Park JS, Gabel AM, Kang L, Canales B, Kassir P, Osei-Ntansah A, Tran ND, Viswanathan S, Lee Y-S, Brewster R
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.10.459675
Epub:
Not Epub
Abstract:
Lack of oxygen (hypoxia and anoxia) is detrimental to cell function and survival and underlies many disease conditions. Hence,...
Link:
https://www.biorxiv.org/content/10.1101/2021.09.10.459675v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Park JS, Gabel AM, Kang L, Canales B, Kassir P, Osei-Ntansah A, Tran ND, Viswanathan S, Lee Y-S, Brewster R. N-myc Downstream Regulated Gene 1 (NDRG1) functions as a molecular switch for cellular adaptation to hypoxia. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.10.459675.

Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis

Authors:
Revenu C, Parlato M, Rosello M, Duroure K, Duclaux-Loras R, Nicolle O, Prospéri M-T, Stoufflet J, Vougny J, Lebreton C, Lépine P, Michaux G, Cerf-Benssusan N, Coudrier E, Del Bene F
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.09.459609
Epub:
Not Epub
Abstract:
Vesicle trafficking and the establishment of apico-basal polarity are essential processes in epithelium morphogenesis. Myosin-...
Link:
https://www.biorxiv.org/content/10.1101/2021.09.09.459609v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Revenu C, Parlato M, Rosello M, Duroure K, Duclaux-Loras R, Nicolle O, Prospéri M-T, Stoufflet J, Vougny J, Lebreton C, Lépine P, Michaux G, Cerf-Benssusan N, Coudrier E, Del Bene F. Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.09.459609.

The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress

Authors:
Stromberg BR, Singh M, Torres AE, Burrows AC, Pal D, Insinna C, Rhee Y, Dickson AS, Westlake CJ, Summers MK
Citation:
J Biol Chem. 2021 Sep 9:101184. doi: 10.1016/j.jbc.2021.101184. Online ahead of print
Epub:
Not Epub
Abstract:
The deubiquitinating enzyme USP37 is known to contribute to timely onset of S-phase and progression of mitosis. However, it is...
Link:
https://www.jbc.org/article/S0021-9258(21)00986-8/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Stromberg BR, Singh M, Torres AE, Burrows AC, Pal D, Insinna C, Rhee Y, Dickson AS, Westlake CJ, Summers MK. The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress. J Biol Chem. 2021 Sep 9:101184. doi: 10.1016/j.jbc.2021.101184. Online ahead of print.

Generation of a Triadin KnockOut Syndrome Zebrafish Model

Authors:
Vecchi VM, Spreafico M, Brix A, Santoni A, Sala S, Pistocchi A, Marozzi A, Di Resta C
Citation:
Int J Mol Sci. 2021;22(18):9720. doi:10.3390/ijms22189720
Epub:
Not Epub
Abstract:
Different forms of sudden cardiac death have been described, including a recently identified form of genetic arrhythmogenic...
Link:
https://www.mdpi.com/1422-0067/22/18/9720
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vecchi VM, Spreafico M, Brix A, Santoni A, Sala S, Pistocchi A, Marozzi A, Di Resta C. Generation of a Triadin KnockOut Syndrome Zebrafish Model. Int J Mol Sci. 2021;22(18):9720. doi:10.3390/ijms22189720 .

Claudin-5a knockdown attenuates blood-neural barrier in zebrafish

Authors:
Ahn JC, Hwang SJ, Lee HJ, Kim KW
Citation:
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Sep 6:109176. doi: 10.1016/j.cbpc.2021.109176. Online ahead of print
Epub:
Yes
Abstract:
Mammalian claudin-5 (cldn5), a zebrafish cldn5a homolog, is essential to blood-brain barrier (BBB) integrity. Previously, the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1532045621002039
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ahn JC, Hwang SJ, Lee HJ, Kim KW. Claudin-5a knockdown attenuates blood-neural barrier in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Sep 6:109176. doi: 10.1016/j.cbpc.2021.109176. Online ahead of print.

Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development

Authors:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA
Citation:
Development. 2021 Sep 1;148(17):dev199684. doi: 10.1242/dev.199684. Epub 2021 Sep 6
Epub:
Not Epub
Abstract:
Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, and craniofacial and/or renal defects. Variants...
Link:
https://journals.biologists.com/dev/article-abstract/148/17/dev199684/272053/Sobp-modulates-the-transcriptional-activation-of
Organism or Cell Type:
Xenopus
Citation Extract:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA. Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development. Development. 2021 Sep 1;148(17):dev199684. doi: 10.1242/dev.199684. Epub 2021 Sep 6.

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling

Authors:
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ
Citation:
Nat Commun. 2021 Sep 6;12(1):5263. doi: 10.1038/s41467-021-25634-z
Epub:
Not Epub
Abstract:
Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of...
Link:
https://www.nature.com/articles/s41467-021-25634-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nat Commun. 2021 Sep 6;12(1):5263. doi: 10.1038/s41467-021-25634-z.

The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development

Authors:
Roffers-Agarwal J, Lidberg KA, Gammill LS
Citation:
Genesis. 2021 Sep 9:e23448. doi: 10.1002/dvg.23448. Online ahead of print
Epub:
Not Epub
Abstract:
SETD2 is a histone H3 lysine 36 (H3K36) tri-methylase that is upregulated in response to neural crest induction. Because the...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/dvg.23448
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Roffers-Agarwal J, Lidberg KA, Gammill LS. The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development. Genesis. 2021 Sep 9:e23448. doi: 10.1002/dvg.23448. Online ahead of print.

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