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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Transcriptomic networks of gba3 governing specification of the dopaminergic neurons in zebrafish embryos

Authors:
Kumar A, Rhee M
Citation:
Genes Genomics. 2022 Oct 1. doi: 10.1007/s13258-022-01317-x. Online ahead of print
Epub:
Yes
Abstract:
Background: Molecular networks associated with dopaminergic (DA) neurogenesis remain undefined within mammalian models. To...
Link:
https://link.springer.com/article/10.1007/s13258-022-01317-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kumar A, Rhee M. Transcriptomic networks of gba3 governing specification of the dopaminergic neurons in zebrafish embryos. Genes Genomics. 2022 Oct 1. doi: 10.1007/s13258-022-01317-x. Online ahead of print.

Cyclin B3 implements timely vertebrate oocyte arrest for fertilization

Authors:
Bouftas N, Schneider L, Halder M, Demmig R, Baack M, Cladière D, Walter M, Al Abdallah H, Kleinhempel C, Messaritaki R, Müller J, Passarelli F, Wehrle P, Heim A, Wassmann K, Mayer TU
Citation:
Dev Cell. 2022;[Epub ahead of print] doi:10.1016/j.devcel.2022.09.005
Epub:
Not Epub
Abstract:
To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580722006359
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Bouftas N, Schneider L, Halder M, Demmig R, Baack M, Cladière D, Walter M, Al Abdallah H, Kleinhempel C, Messaritaki R, Müller J, Passarelli F, Wehrle P, Heim A, Wassmann K, Mayer TU. Cyclin B3 implements timely vertebrate oocyte arrest for fertilization. Dev Cell. 2022;[Epub ahead of print] doi:10.1016/j.devcel.2022.09.005.

Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells

Authors:
Hovland AS, Bhattacharya D, Azambuja AP, Pramio D, Copeland J, Rothstein M, Simoes-Costa M
Citation:
Dev Cell. 2022;[Epub ahead of print] doi:10.1016/j.devcel.2022.09.006
Epub:
Not Epub
Abstract:
Yamanaka factors are essential for establishing pluripotency in embryonic stem cells, but their function in multipotent stem...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580722006360
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Hovland AS, Bhattacharya D, Azambuja AP, Pramio D, Copeland J, Rothstein M, Simoes-Costa M. Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells. Dev Cell. 2022;[Epub ahead of print] doi:10.1016/j.devcel.2022.09.006.

Zbtb21 is required for the anterior-posterior patterning of neural tissue in the early Xenopus embryo

Authors:
Takebayashi-Suzuki K, Uchida M, Suzuki A
Citation:
Biochem Biophys Res Commun. 2022 Sep 15;630:190-197. doi: 10.1016/j.bbrc.2022.09.048. Online ahead of print
Epub:
Not Epub
Abstract:
The vertebrate body is organized along the dorsal-ventral (DV) and anterior-posterior (AP) axes by the BMP and Wnt pathways,...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X22013043
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Takebayashi-Suzuki K, Uchida M, Suzuki A. Zbtb21 is required for the anterior-posterior patterning of neural tissue in the early Xenopus embryo. Biochem Biophys Res Commun. 2022 Sep 15;630:190-197. doi: 10.1016/j.bbrc.2022.09.048. Online ahead of print.

Transcription factors interact with RNA to regulate genes

Authors:
Oksuz O, Henninger JE, Warneford-Thomson W, Zheng MM, Erb H, Overholt KJ, Hawken SW, Banani SF, Lauman R, Vancura A, Robertson AL, Hannett NM, Lee T, Zon LI, Bonasio R, Young RA
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.09.27.509776
Epub:
Not Epub
Abstract:
Transcription factors (TFs) orchestrate the gene expression programs that define each cell's identity. The canonical TF...
Link:
https://www.biorxiv.org/content/10.1101/2022.09.27.509776v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oksuz O, Henninger JE, Warneford-Thomson W, Zheng MM, Erb H, Overholt KJ, Hawken SW, Banani SF, Lauman R, Vancura A, Robertson AL, Hannett NM, Lee T, Zon LI, Bonasio R, Young RA. Transcription factors interact with RNA to regulate genes. bioRxiv. 2022;[preprint] doi:10.1101/2022.09.27.509776.

eIF4B mRNA Translation Contributes to Cleavage Dynamics in Early Sea Urchin Embryos

Authors:
Pontheaux F, Boulben S, Chassé H, Boutet A, Roch F, Morales J, Cormier P
Citation:
Biology. 2022;11(10):1408. doi:10.3390/biology11101408
Epub:
Not Epub
Abstract:
During the first steps of sea urchin development, fertilization elicits a marked increase in protein synthesis essential for...
Link:
https://www.mdpi.com/article/10.3390/biology11101408/s1
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus, Sphaerechinus granularis (sea urchins)
Citation Extract:
Pontheaux F, Boulben S, Chassé H, Boutet A, Roch F, Morales J, Cormier P. eIF4B mRNA Translation Contributes to Cleavage Dynamics in Early Sea Urchin Embryos. Biology. 2022;11(10):1408. doi:10.3390/biology11101408 .

Ash2l, an obligatory component of H3K4 methylation complexes, regulates neural crest development

Authors:
Mohammadparast S, Chang C
Citation:
Dev Biol. 2022 Sep 23:S0012-1606(22)00179-8. doi: 10.1016/j.ydbio.2022.09.008. Online ahead of print
Epub:
Yes
Abstract:
The vertebrate nervous system develops from embryonic neural plate and neural crest. Although genetic mechanisms governing...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160622001798
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Mohammadparast S, Chang C. Ash2l, an obligatory component of H3K4 methylation complexes, regulates neural crest development. Dev Biol. 2022 Sep 23:S0012-1606(22)00179-8. doi: 10.1016/j.ydbio.2022.09.008. Online ahead of print.

Exon skipping induces uniform dystrophin rescue with dose-dependent restoration of serum miRNA biomarkers and muscle biophysical properties

Authors:
Chwalenia K, Oieni J, Zemła J, Lekka M, Ahlskog N, Coenen-Stass AML, McClorey G, Wood MJA, Lomonosova Y, Roberts TC
Citation:
Mol Ther Nucleic Acids. 2022 Aug 25;29:955-968. doi: 10.1016/j.omtn.2022.08.033. eCollection 2022
Epub:
Not Epub
Abstract:
Therapies that restore dystrophin expression are presumed to correct Duchenne muscular dystrophy (DMD), with antisense-mediated...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(22)00232-3
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Chwalenia K, Oieni J, Zemła J, Lekka M, Ahlskog N, Coenen-Stass AML, McClorey G, Wood MJA, Lomonosova Y, Roberts TC. Exon skipping induces uniform dystrophin rescue with dose-dependent restoration of serum miRNA biomarkers and muscle biophysical properties. Mol Ther Nucleic Acids. 2022 Aug 25;29:955-968. doi: 10.1016/j.omtn.2022.08.033. eCollection 2022.

Regulation of Nodal signaling propagation by receptor interactions and positive feedback

Authors:
Preiß H, Kögler AC, Mörsdorf D, Čapek D, Soh GH, Rogers KW, Morales-Navarrete H, Almuedo-Castillo M, Müller P
Citation:
Elife. 2022 Sep 23;11:e66397. doi: 10.7554/eLife.66397. Online ahead of print
Epub:
Not Epub
Abstract:
During vertebrate embryogenesis, the germ layers are patterned by secreted Nodal signals. In the classical model, Nodals elicit...
Link:
https://elifesciences.org/articles/66397
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Preiß H, Kögler AC, Mörsdorf D, Čapek D, Soh GH, Rogers KW, Morales-Navarrete H, Almuedo-Castillo M, Müller P. Regulation of Nodal signaling propagation by receptor interactions and positive feedback. Elife. 2022 Sep 23;11:e66397. doi: 10.7554/eLife.66397. Online ahead of print.

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

Authors:
Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Kim JW, Budnik B, Zon LI
Citation:
Science. 2022 Sep 23;377(6613):1413-1419. doi: 10.1126/science.abo4837. Epub 2022 Sep 22
Epub:
Not Epub
Abstract:
Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer...
Link:
https://www.science.org/doi/10.1126/science.abo4837
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Kim JW, Budnik B, Zon LI. Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 Sep 23;377(6613):1413-1419. doi: 10.1126/science.abo4837. Epub 2022 Sep 22.

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