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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model
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Citation:
Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17 Epub:
Not Epub Abstract:
The use of vertebrate models allows researchers to investigate mechanisms of CCM pathogenesis in vivo, to investigate... Organism or Cell Type:
zebrafish Citation Extract: Abou-Fadel J, Zhang J. Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model. Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17. |
Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.09.141408 Epub:
Not Epub Abstract:
Within vascular networks, wall shear stress (WSS) modulates endothelial cell proliferation and arteriovenous specification.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Baek KI, Chang S-S, Chang C-C, Roustaei M, Ding Y, Wang Y, Chen J, Odonnelle R, Chen H, Ashby JW, Mack JJ, Xu X, Cavallero S, Hsiai TK. Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.09.141408. |
Patient-specific functional genomics and disease modeling suggest a role for LRP2 in Hypoplastic Left Heart Syndrome
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Citation:
bioRxiv. 2020:835439;[preprint] doi:10.1101/835439 Epub:
Not Epub Abstract:
Background: Congenital heart diseases, such as hypoplastic left heart syndrome (HLHS), are considered to have complex genetic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Theis JL, Vogler G, Missinato MA, Li X, Martinez-Fernandez A, Nielsen T, Walls SM, Kervadec A, Zeng X-XI, Kezos JM, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Colas AR, Nelson TJ, Olson TM, Bodmer R. Patient-specific functional genomics and disease modeling suggest a role for LRP2 in Hypoplastic Left Heart Syndrome. bioRxiv. 2020:835439;[preprint] doi:10.1101/835439. |
Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells
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Citation:
Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490 Epub:
Not Epub Abstract:
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: human primary bronchial epithelial cells Citation Extract: Michaels WE, Bridges RJ, Hastings ML. Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells. Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490. |
Viltolarsen: First Approval
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Citation:
Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print Epub:
Yes Abstract:
Viltolarsen (Viltepso® in Japan) is a phosphorodiamidate morpholino antisense oligonucleotide being developed by Nippon... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Dhillon S. Viltolarsen: First Approval. Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print. |
U1 snRNP Telescripting Roles in Transcription and Its Mechanism
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Citation:
Cold Spring Harb Symp Quant Biol. 2020 Jun 9:040451. doi:10.1101/sqb.2019.84.040451. Online ahead of print Epub:
Not Epub Abstract:
Telescripting is a fundamental cotranscriptional gene regulation process that relies on U1 snRNP (U1) to suppress premature 3... Organism or Cell Type:
cell culture Citation Extract: Di C, So BR, Cai Z, Arai C, Duan J, Dreyfuss G. U1 snRNP Telescripting Roles in Transcription and Its Mechanism. Cold Spring Harb Symp Quant Biol. 2020 Jun 9:040451. doi:10.1101/sqb.2019.84.040451. Online ahead of print. |
Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein
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Citation:
Exp Neurol. 2020;328:113283 doi:10.1016/j.expneurol.2020.113283 Epub:
Not Epub Abstract:
It has been proposed that Amyloid β Precursor Protein (APP) might act as a rheostat controlling neuronal excitability, but... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kanyo R, Leighton PLA, Neil GJ, Locskai LF, Allison WT. Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein. Exp Neurol. 2020;328:113283 doi:10.1016/j.expneurol.2020.113283. |
Lamprey VLRB participates in pathogen detection, VLRB/L-BLNK/L-NF-κB (B-like cells) signal transduction, and development
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Citation:
Fish Shellfish Immun. 2020;[Epub ahead of print] doi:10.1016/j.fsi.2020.05.030 Epub:
Yes Abstract:
In jawed vertebrates, B cell receptors (BCR) are primary pathogen detectors that activate downstream signaling pathways to... Delivery Method:
microinjection Organism or Cell Type:
Lampetra morii (lamprey) Citation Extract: Han Y, Li J, Pang Y, Xu L, Ma Q, Liu H, Song X, Su P, Sun F, Gou M, Lu J, Shan Y, Liu X, Li Q. Lamprey VLRB participates in pathogen detection, VLRB/L-BLNK/L-NF-κB (B-like cells) signal transduction, and development. Fish Shellfish Immun. 2020;[Epub ahead of print] doi:10.1016/j.fsi.2020.05.030. |
Acute knockdown of extracellular matrix protein Tinagl1 disrupts heart laterality and pronephric cilia in zebrafish embryonic development
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Citation:
bioRxiv. 2020;[preprint] doi: doi:10.1101/2020.06.05.136747 Epub:
Not Epub Abstract:
A highly-conserved extracellular matrix protein, Tinagl1, modulates Wnt, integrin, TGF-β, and EGF-R signaling in vitro, but its... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Neiswender H, LeMosy EK. Acute knockdown of extracellular matrix protein Tinagl1 disrupts heart laterality and pronephric cilia in zebrafish embryonic development. bioRxiv. 2020;[preprint] doi: doi:10.1101/2020.06.05.136747. |
Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF
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Citation:
Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.118 Epub:
Yes Abstract:
The primary contributor for the determination of skin color is melanin, a pigment that is produced in specialized cells called... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rai A, Chatterjee B, Bhowmick S, Sagar S, Roy SS. Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF. Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.118. |