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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model

Authors:
Ramsbottom SA, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, Devlin LA, White K, Steel DH, Saunier S, Miles CG, Sayer JA
Citation:
Proc Natl Acad Sci U S A. 2018 Nov 16. pii: 201809432. doi: 10.1073/pnas.1809432115. [Epub ahead of print]
Epub:
Yes
Abstract:
Genetic treatments of renal ciliopathies leading to cystic kidney disease would provide a real advance in current therapies....
Link:
http://www.pnas.org/content/early/2018/11/15/1809432115
Delivery Method:
Endo-Porter, Vivo-Morpholino
Organism or Cell Type:
cell culture: human urine-derived renal epithelial kidney cells (hURECs), Cep290Gt mice
Citation Extract:
Ramsbottom SA, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, Devlin LA, White K, Steel DH, Saunier S, Miles CG, Sayer JA. Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model. Proc Natl Acad Sci U S A. 2018 Nov 16. pii: 201809432. doi: 10.1073/pnas.1809432115. [Epub ahead of print].

Lin CY, Zhang PH, Chen YJ, Wu CL, Tsai HJ

Authors:
Conditional Overexpression of rtn4al in Muscle of Adult Zebrafish Displays Defects Similar to Human Amyotrophic Lateral Sclerosis
Citation:
Mar Biotechnol (NY). 2018 Nov 15. doi: 10.1007/s10126-018-9857-x. [Epub ahead of print]
Epub:
Yes
Abstract:
The protein level of muscle-specific human NogoA is abnormally upregulated in amyotrophic lateral sclerosis (ALS) mice and...
Link:
http://link-springer-com-443.webvpn.jxutcm.edu.cn/article/10.1007%2Fs10126-018-9857-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Conditional Overexpression of rtn4al in Muscle of Adult Zebrafish Displays Defects Similar to Human Amyotrophic Lateral Sclerosis. Lin CY, Zhang PH, Chen YJ, Wu CL, Tsai HJ. Mar Biotechnol (NY). 2018 Nov 15. doi: 10.1007/s10126-018-9857-x. [Epub ahead of print].

Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio)

Authors:
Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ
Citation:
Gen Comp Endocrinol. 2018 Nov 15. pii: S0016-6480(18)30305-8. doi: 10.1016/j.ygcen.2018.11.007. [Epub ahead of print]
Epub:
Yes
Abstract:
Thyroid hormones (THs) regulate neurodevelopment, thus TH disruption is widely posited as a mechanism of developmental...
Link:
https://www.sciencedirect.com/science/article/pii/S0016648018303058
Organism or Cell Type:
zebrafish
Citation Extract:
Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ. Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). Gen Comp Endocrinol. 2018 Nov 15. pii: S0016-6480(18)30305-8. doi: 10.1016/j.ygcen.2018.11.007. [Epub ahead of print].

Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos

Authors:
Kelu JJ, Webb SE, Galione A, Miller AL
Citation:
Dev Biol. 2018 Nov 14. pii: S0012-1606(18)30508-6. doi: 10.1016/j.ydbio.2018.11.005. [Epub ahead of print]
Epub:
Yes
Abstract:
We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160618305086
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kelu JJ, Webb SE, Galione A, Miller AL. Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos. Dev Biol. 2018 Nov 14. pii: S0012-1606(18)30508-6. doi: 10.1016/j.ydbio.2018.11.005. [Epub ahead of print].

Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix

Authors:
Love AM, Prince DJ, Jessen JR
Citation:
Development. 2018 Oct 16. pii: dev.165472. doi: 10.1242/dev.165472. [Epub ahead of print]
Epub:
Yes
Abstract:
During zebrafish gastrulation the planar cell polarity (PCP) protein Vang-like 2 (Vangl2) regulates polarization of cells...
Link:
http://dev.biologists.org/content/145/22/dev165472
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Love AM, Prince DJ, Jessen JR. Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix. Development. 2018 Oct 16. pii: dev.165472. doi: 10.1242/dev.165472. [Epub ahead of print].

Tyro3 is a podocyte protective factor in glomerular disease

Authors:
Zhong F, Chen Z, Zhang L, Xie Y, Nair V, Ju W, Kretzler M, Nelson RG, Li Z, Chen H, Wang Y, Zhang A, Lee K,1 Liu Z, He JC
Citation:
JCI Insight. 2018;3(22):e123482. doi:10.1172/jci.insight.123482
Epub:
Not Epub
Abstract:
Our previous work demonstrated a protective role of protein S in early diabetic kidney disease (DKD). Protein S exerts...
Link:
https://insight.jci.org/articles/view/123482
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhong F, Chen Z, Zhang L, Xie Y, Nair V, Ju W, Kretzler M, Nelson RG, Li Z, Chen H, Wang Y, Zhang A, Lee K,1 Liu Z, He JC. Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight. 2018;3(22):e123482. doi:10.1172/jci.insight.123482.

Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase

Authors:
Gutzman JH, Graeden E, Brachmann I, Yamazoe S, Chen JK, Sive H
Citation:
Biol Open. 2018 Nov 13;7(11). pii: bio034520. doi: 10.1242/bio.034520
Epub:
Not Epub
Abstract:
Basal constriction occurs at the zebrafish midbrain-hindbrain boundary constriction (MHBC) and is likely a widespread...
Link:
http://bio.biologists.org/content/7/11/bio034520
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gutzman JH, Graeden E, Brachmann I, Yamazoe S, Chen JK, Sive H. Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Biol Open. 2018 Nov 13;7(11). pii: bio034520. doi: 10.1242/bio.034520.

An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus

Authors:
Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, Beyer T, Schweickert A, Blum M
Citation:
iScience. 2018 Apr 27;2:76-85. doi: 10.1016/j.isci.2018.03.011. Epub 2018 Apr 7
Epub:
Not Epub
Abstract:
Nodal signaling controls asymmetric organ placement during vertebrate embryogenesis. Nodal is induced by a leftward fluid flow...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(18)30020-8
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, Beyer T, Schweickert A, Blum M. An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus. iScience. 2018 Apr 27;2:76-85. doi: 10.1016/j.isci.2018.03.011. Epub 2018 Apr 7.

Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1

Authors:
Gao C, Huang W, Gao Y, Jan Lo L, Luo L, Huang H, Chen J, Peng J
Citation:
J Mol Cell Biol. 2018 Nov 14. doi: 10.1093/jmcb/mjy068. [Epub ahead of print]
Epub:
Yes
Abstract:
The hepatopancreatic duct (HPD) system links the liver and pancreas to the intestinal tube and is composed of the extrahepatic...
Link:
https://academic.oup.com/jmcb/advance-article/doi/10.1093/jmcb/mjy068/5183219
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gao C, Huang W, Gao Y, Jan Lo L, Luo L, Huang H, Chen J, Peng J. Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1. J Mol Cell Biol. 2018 Nov 14. doi: 10.1093/jmcb/mjy068. [Epub ahead of print].

Homozygous splicing mutation in NUP133 causes Galloway-Mowat syndrome

Authors:
Fujita A, Tsukaguchi H, Koshimizu E, Nakazato H, Itoh K, Kuraoka S, Komohara Y, Shiina M, Nakamura S, Kitajima M, Tsurusaki Y, Miyatake S, Ogata K, Iijima K, Matsumoto N, Miyake N
Citation:
Ann Neurol. 2018 Nov 14. doi: 10.1002/ana.25370. [Epub ahead of print]
Epub:
Yes
Abstract:
OBJECTIVE: Galloway-Mowat syndrome (GAMOS) is a neural and renal disorder, characterized by microcephaly, brain anomalies, and...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/ana.25370
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fujita A, Tsukaguchi H, Koshimizu E, Nakazato H, Itoh K, Kuraoka S, Komohara Y, Shiina M, Nakamura S, Kitajima M, Tsurusaki Y, Miyatake S, Ogata K, Iijima K, Matsumoto N, Miyake N. Homozygous splicing mutation in NUP133 causes Galloway-Mowat syndrome. Ann Neurol. 2018 Nov 14. doi: 10.1002/ana.25370. [Epub ahead of print].

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