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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target

Authors:
Ibhazehiebo K, Gavrilovici C, de la Hoz CL, Ma S-C, Rehak R, Kaushik G, Meza Santoscoy PL, Scott L, Nath N, Kim D-Y, Rho JM, Kurrasch DM
Citation:
Brain 2018;awx364. doi:10.1093/brain/awx364
Epub:
Not Epub
Abstract:
Despite the development of newer anti-seizure medications over the past 50 years, 30-40% of patients with epilepsy remain...
Link:
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awx364/4823617
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ibhazehiebo K, Gavrilovici C, de la Hoz CL, Ma S-C, Rehak R, Kaushik G, Meza Santoscoy PL, Scott L, Nath N, Kim D-Y, Rho JM, Kurrasch DM. A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target. Brain 2018;awx364. doi:10.1093/brain/awx364.

Nodal induces sequential restriction of germ cell factors during primordial germ cell specification

Authors:
Fresques TM, Wessel GM
Citation:
Development. 2018;145(2):dev155663. doi:10.1242/dev.155663
Epub:
Not Epub
Abstract:
Specification of the germ cell lineage is required for sexual reproduction in animals. The mechanism of germ cell specification...
Link:
http://dev.biologists.org/content/145/2/dev155663
Delivery Method:
microinjection
Organism or Cell Type:
sea star
Citation Extract:
Fresques TM, Wessel GM. Nodal induces sequential restriction of germ cell factors during primordial germ cell specification. Development. 2018;145(2):dev155663. doi:10.1242/dev.155663.

Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings

Authors:
Louw JJ, Nunes Bastos R, Chen X, Verdood C, Corveleyn A, Jia Y, Breckpot J, Gewillig M, Peeters H, Santoro MM, Barr F, Devriendt K
Citation:
PLoS Genet. 2018 Jan 22;14(1):e1007138. doi: 10.1371/journal.pgen.1007138. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Congenital or neonatal cardiomyopathies are commonly associated with a poor prognosis and have multiple etiologies. In two...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007138
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Louw JJ, Nunes Bastos R, Chen X, Verdood C, Corveleyn A, Jia Y, Breckpot J, Gewillig M, Peeters H, Santoro MM, Barr F, Devriendt K. Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings. PLoS Genet. 2018 Jan 22;14(1):e1007138. doi: 10.1371/journal.pgen.1007138. [Epub ahead of print].

Monitoring dissociation kinetics during electrophoretic focusing enables high-specificity nucleic acid detection

Authors:
Zeidman Kalman T, Khalandovsky R, Tenenbaum Gonikman E, Bercovici M
Citation:
Angew Chem. 2018;[Epub ahead of print] doi:10.1002/ange.201711673
Epub:
Yes
Abstract:
A wide range of medical conditions can be diagnosed through sequence-specific analysis of nucleic acids. However, a major...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/ange.201711673/abstract
Citation Extract:
Zeidman Kalman T, Khalandovsky R, Tenenbaum Gonikman E, Bercovici M. Monitoring dissociation kinetics during electrophoretic focusing enables high-specificity nucleic acid detection. Angew Chem. 2018;[Epub ahead of print] doi:10.1002/ange.201711673.

Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish

Authors:
Gerri C, Marass M, Rossi A, Stainier DYR
Citation:
Blood. 2018 Jan 16. pii: blood-2017-07-797795. doi: 10.1182/blood-2017-07-797795. [Epub ahead of print]
Epub:
Yes
Abstract:
During development, hematopoietic stem cells (HSCs) derive from specialized endothelial cells (ECs), called hemogenic...
Link:
http://www.bloodjournal.org/content/early/2018/01/16/blood-2017-07-797795.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gerri C, Marass M, Rossi A, Stainier DYR. Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish. Blood. 2018 Jan 16. pii: blood-2017-07-797795. doi: 10.1182/blood-2017-07-797795. [Epub ahead of print].

Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish

Authors:
Liu Z-Z, Wang Z-L, Choi T-I, Huang W-T, Wang H-T, Han Y-Y, Zhu L-Y, Kim H-T, Choi J-H, Lee J-S, Kim H-G, Zhao J, Chen Y, Lu Z, Tian X-L, Pan B-X, Li B-M, Kim C-H
Citation:
Am J. Pathol. 2018;[Epub ahead of print] doi:10.1016/j.ajpath.2017.12.005
Epub:
Yes
Abstract:
CHARGE syndrome is a congenital disorder affecting multiple organs and mainly caused by mutations in CHD7, a gene encoding a...
Link:
http://ajp.amjpathol.org/article/S0002-9440(17)30669-7/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu Z-Z, Wang Z-L, Choi T-I, Huang W-T, Wang H-T, Han Y-Y, Zhu L-Y, Kim H-T, Choi J-H, Lee J-S, Kim H-G, Zhao J, Chen Y, Lu Z, Tian X-L, Pan B-X, Li B-M, Kim C-H. Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish. Am J. Pathol. 2018;[Epub ahead of print] doi:10.1016/j.ajpath.2017.12.005.

Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia

Authors:
Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A
Citation:
Sci Signal. 2018;11(513):eaan6831. doi:10.1126/scisignal.aan6831
Epub:
Not Epub
Abstract:
The transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) family of cytokines critically regulates vascular...
Link:
http://stke.sciencemag.org/content/11/513/eaan6831.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018;11(513):eaan6831. doi:10.1126/scisignal.aan6831.

Microinjection of Antisense Morpholinos, CRISPR/Cas9 RNP, and RNA/DNA into Zebrafish Embryos

Authors:
Xin Y, Duan C
Citation:
Methods Mol Biol. 2018;1742:205-211. doi: 10.1007/978-1-4939-7665-2_18
Epub:
Not Epub
Abstract:
In this chapter, we describe a stepwise protocol of microinjection. Using this method, antisense morpholinos, CRISPR-Cas9...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-7665-2_18
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xin Y, Duan C. Microinjection of Antisense Morpholinos, CRISPR/Cas9 RNP, and RNA/DNA into Zebrafish Embryos. Methods Mol Biol. 2018;1742:205-211. doi: 10.1007/978-1-4939-7665-2_18.

Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response

Authors:
Paone C, Rudeck S, Etard C, Strähle U, Rottbauer W, Just S
Citation:
Biochem Biophys Res Commun. 2018 Jan 10. pii: S0006-291X(18)30066-4. doi: 10.1016/j.bbrc.2018.01.060. [Epub ahead of print]
Epub:
Yes
Abstract:
Sarcomeric protein turnover needs to be tightly balanced to assure proper assembly and renewal of sarcomeric units within...
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X18300664
Citation Extract:
Paone C, Rudeck S, Etard C, Strähle U, Rottbauer W, Just S. Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response. Biochem Biophys Res Commun. 2018 Jan 10. pii: S0006-291X(18)30066-4. doi: 10.1016/j.bbrc.2018.01.060. [Epub ahead of print].

Transient Disruption of Adenosine Signaling During Embryogenesis Triggers a Pro-epileptic Phenotype in Adult Zebrafish

Authors:
Menezes FP, Machado Torresini F, Nery LR, da Silva RS
Citation:
Mol Neurobiol. 2018 Jan 11. doi: 10.1007/s12035-017-0850-6. [Epub ahead of print]
Epub:
Yes
Abstract:
Adenosinergic signaling has important effects on brain function, anatomy, and physiology in both late and early stages of...
Link:
https://link.springer.com/article/10.1007%2Fs12035-017-0850-6
Organism or Cell Type:
zebrafish
Citation Extract:
Menezes FP, Machado Torresini F, Nery LR, da Silva RS. Transient Disruption of Adenosine Signaling During Embryogenesis Triggers a Pro-epileptic Phenotype in Adult Zebrafish. Mol Neurobiol. 2018 Jan 11. doi: 10.1007/s12035-017-0850-6. [Epub ahead of print].

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