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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface

Authors:
Dubaissi E, Rousseau K, Hughes GW, Ridley C, Grencis RK, Roberts IS, Thornton DJ
Citation:
PNAS USA. 2017;[Epub ahead of print] doi:10.1073/pnas.1713539115
Epub:
Yes
Abstract:
Mucosal surfaces represent critical routes for entry and exit of pathogens. As such, animals have evolved strategies to combat...
Link:
http://www.pnas.org/content/early/2018/01/03/1713539115
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Dubaissi E, Rousseau K, Hughes GW, Ridley C, Grencis RK, Roberts IS, Thornton DJ. Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface. PNAS USA. 2017;[Epub ahead of print] doi:10.1073/pnas.1713539115.

Rapid detection of exosomal microRNA biomarkers by electrokinetic concentration for liquid biopsy on chip

Authors:
Cheung LS, Wei X, Martins D, Song Y-A
Citation:
Biomicrofluidics. 2018;12:014104. doi:10.1063/1.5009719
Epub:
Not Epub
Abstract:
An ion concentration polarization (ICP)-based electrokinetic concentration device is used for accelerating the surface...
Link:
http://aip.scitation.org/doi/10.1063/1.5009719
Citation Extract:
Cheung LS, Wei X, Martins D, Song Y-A. Rapid detection of exosomal microRNA biomarkers by electrokinetic concentration for liquid biopsy on chip. Biomicrofluidics. 2018;12:014104. doi:10.1063/1.5009719.

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism

Authors:
Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs AM, Petrucelli L, Lemmens R, Van Damme P, Van Den Bosch L, Robberecht W
Citation:
Acta Neuropathol. 2018 Jan 4. doi: 10.1007/s00401-017-1796-5. [Epub ahead of print]
Epub:
Yes
Abstract:
The exact mechanism underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with the GGGGCC...
Link:
https://link.springer.com/article/10.1007%2Fs00401-017-1796-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs AM, Petrucelli L, Lemmens R, Van Damme P, Van Den Bosch L, Robberecht W. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Acta Neuropathol. 2018 Jan 4. doi: 10.1007/s00401-017-1796-5. [Epub ahead of print].

KIAA1109 Variants Are Associated with a Severe Disorder of Brain Development and Arthrogryposis

Authors:
Gueneau L, Fish RJ, Shamseldin HE, Voisin N, Tran Mau-Them F, Preiksaitiene E, Monroe GR, Lai A, Putoux A, Allias F, Ambusaidi Q, Ambrozaityte L, Cimbalistienė L, Delafontaine J, Guex N, Hashem M, Kurdi W, Jamuar SS, Ying LJ, Bonnard C, Pippucci T, Pradervand S, Roechert B, van Hasselt PM, Wiederkehr M, Wright CF; DDD Study, Xenarios I, van Haaften G, Shaw-Smith C, Schindewolf EM, Neerman-Arbez M, Sanlaville D, Lesca G, Guibaud L, Reversade B, Chelly J, Kučinskas V, Alkuraya FS, Reymond A
Citation:
Am J Hum Genet. 2018 Jan 4;102(1):116-132. doi: 10.1016/j.ajhg.2017.12.002. Epub 2017 Dec 28
Epub:
Not Epub
Abstract:
Whole-exome and targeted sequencing of 13 individuals from 10 unrelated families with overlapping clinical manifestations...
Link:
http://www.cell.com/ajhg/fulltext/S0002-9297(17)30491-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gueneau L, Fish RJ, Shamseldin HE, Voisin N, Tran Mau-Them F, Preiksaitiene E, Monroe GR, Lai A, Putoux A, Allias F, Ambusaidi Q, Ambrozaityte L, Cimbalistienė L, Delafontaine J, Guex N, Hashem M, Kurdi W, Jamuar SS, Ying LJ, Bonnard C, Pippucci T, Pradervand S, Roechert B, van Hasselt PM, Wiederkehr M, Wright CF; DDD Study, Xenarios I, van Haaften G, Shaw-Smith C, Schindewolf EM, Neerman-Arbez M, Sanlaville D, Lesca G, Guibaud L, Reversade B, Chelly J, Kučinskas V, Alkuraya FS, Reymond A. KIAA1109 Variants Are Associated with a Severe Disorder of Brain Development and Arthrogryposis. Am J Hum Genet. 2018 Jan 4;102(1):116-132. doi: 10.1016/j.ajhg.2017.12.002. Epub 2017 Dec 28.

Investigation of New Morpholino Oligomers to Increase Survival Motor Neuron Protein Levels in Spinal Muscular Atrophy

Authors:
Ramirez A, Crisafulli SG, Rizzuti M, Bresolin N, Comi GP, Corti S, Nizzardo M
Citation:
Int J Molec Sci. 2018;19(1):167. doi:10.3390/ijms19010167
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is an autosomal-recessive childhood motor neuron disease and the main genetic cause of infant...
Link:
http://www.mdpi.com/1422-0067/19/1/167
Delivery Method:
electroporation in culture; intracerebroventricular (icv) injection, subcutaneous (sc) injection
Organism or Cell Type:
cell culture: HeLa, SMA iPSC; SMA mice
Citation Extract:
Ramirez A, Crisafulli SG, Rizzuti M, Bresolin N, Comi GP, Corti S, Nizzardo M. Investigation of New Morpholino Oligomers to Increase Survival Motor Neuron Protein Levels in Spinal Muscular Atrophy. Int J Molec Sci. 2018;19(1):167. doi:10.3390/ijms19010167.

RAPGEF5 Regulates Nuclear Translocation of β-Catenin

Authors:
Griffin JN, del Viso F, Duncan AR, Robson A, Hwang W, Kulkarni S, Liu KJ, Khokha MK
Citation:
Dev Cell. 2017;[Epub ahead of print] doi:10.1016/j.devcel.2017.12.001
Epub:
Yes
Abstract:
Canonical Wnt signaling coordinates many critical aspects of embryonic development, while dysregulated Wnt signaling...
Link:
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30986-3
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Griffin JN, del Viso F, Duncan AR, Robson A, Hwang W, Kulkarni S, Liu KJ, Khokha MK. RAPGEF5 Regulates Nuclear Translocation of β-Catenin. Dev Cell. 2017;[Epub ahead of print] doi:10.1016/j.devcel.2017.12.001.

The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation

Authors:
Gross-Thebing T, Yigit S, Pfeiffer J, Reichman-Fried M, Bandemer J, Ruckert C, Rathmer C, Goudarzi M, Stehling M, Tarbashevich K, Seggewiss J, Raz E
Citation:
Dev Cell. 2017 Dec 18;43(6):704-715.e5. doi: 10.1016/j.devcel.2017.11.019
Epub:
Not Epub
Abstract:
Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types....
Link:
http://www.cell.com/developmental-cell/abstract/S1534-5807(17)30954-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gross-Thebing T, Yigit S, Pfeiffer J, Reichman-Fried M, Bandemer J, Ruckert C, Rathmer C, Goudarzi M, Stehling M, Tarbashevich K, Seggewiss J, Raz E. The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation. Dev Cell. 2017 Dec 18;43(6):704-715.e5. doi: 10.1016/j.devcel.2017.11.019.

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways

Authors:
Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G 3rd, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF
Citation:
Dev Cell. 2017 Dec 18;43(6):744-762.e11. doi: 10.1016/j.devcel.2017.11.014
Epub:
Not Epub
Abstract:
Cilia are organelles specialized for movement and signaling. To infer when during evolution signaling pathways became...
Link:
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30949-8
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G 3rd, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 Dec 18;43(6):744-762.e11. doi: 10.1016/j.devcel.2017.11.014.

Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages

Authors:
van Boxtel AL, Economou AD, Heliot C, Hill CS
Citation:
Dev Cell. 2017 Dec 20. pii: S1534-5807(17)30982-6. doi: 10.1016/j.devcel.2017.11.021. [Epub ahead of print]
Epub:
Yes
Abstract:
Specification of the three germ layers by graded Nodal signaling has long been seen as a paradigm for patterning through a...
Link:
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30982-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van Boxtel AL, Economou AD, Heliot C, Hill CS. Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages. Dev Cell. 2017 Dec 20. pii: S1534-5807(17)30982-6. doi: 10.1016/j.devcel.2017.11.021. [Epub ahead of print].

Role of the Visual Experience-Dependent Nascent Proteome in Neuronal Plasticity

Authors:
Liu H-H, McClatchy DB, Schiapparelli L, Shen W, Yates JR III, Cline HT
Citation:
bioRxiv. 2017. doi:10.1101/240119
Epub:
Yes
Abstract:
Experience-dependent synaptic plasticity refines brain circuits during development. To identify novel protein synthesis-...
Link:
https://www.biorxiv.org/content/early/2017/12/27/240119
Delivery Method:
intracerebroventricular injection then electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Liu H-H, McClatchy DB, Schiapparelli L, Shen W, Yates JR III, Cline HT. Role of the Visual Experience-Dependent Nascent Proteome in Neuronal Plasticity. bioRxiv. 2017. doi:10.1101/240119.

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