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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish

Authors:
Bhatia S, Gordon CT, Foster RG, Melin L, Abadie V, Baujat G, Vazquez MP, Amiel J, Lyonnet S, Heyningen Vv, Kleinjan DA
Citation:
PLoS Genet. 2015 Jun 1;11(6):e1005193. doi: 10.1371/journal.pgen.1005193. eCollection 2015 Jun
Epub:
Not Epub
Abstract:
Disruption of gene regulation by sequence variation in non-coding regions of the genome is now recognised as a significant...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bhatia S, Gordon CT, Foster RG, Melin L, Abadie V, Baujat G, Vazquez MP, Amiel J, Lyonnet S, Heyningen Vv, Kleinjan DA. Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish. PLoS Genet. 2015 Jun 1;11(6):e1005193. doi: 10.1371/journal.pgen.1005193. eCollection 2015 Jun.

Knockdown of central ghrelin O-acyltransferase by vivo-morpholino reduces body mass of rats fed a high-fat diet

Authors:
Wellman M, Abizaid A
Citation:
Peptides. 2015 May 28. pii: S0196-9781(15)00163-1. doi: 10.1016/j.peptides.2015.05.007. [Epub ahead of print]
Epub:
Yes
Abstract:
The enzyme ghrelin O-acyltransferase (GOAT) activates the orexigenic peptide ghrelin by transferring an acyl group from fatty...
Delivery Method:
Vivo-Morpholino i.c.v.
Organism or Cell Type:
rat
Citation Extract:
Wellman M, Abizaid A. Knockdown of central ghrelin O-acyltransferase by vivo-morpholino reduces body mass of rats fed a high-fat diet. Peptides. 2015 May 28. pii: S0196-9781(15)00163-1. doi: 10.1016/j.peptides.2015.05.007. [Epub ahead of print].

Loss of Function Mutations in NNT Are Associated with Left Ventricular Noncompaction

Authors:
Bainbridge MN, Davis EE, Choi WY, Dickson A, Martinez HR, Wang M, Dinh H, Muzny D, Pignatelli R, Katsanis N, Boerwinkle E, Gibbs R, Jefferies JL
Citation:
Circ Cardiovasc Genet. 2015 May 29. pii: CIRCGENETICS.115.001026. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Left ventricular noncompaction (LVNC) is an autosomal dominant, genetically heterogeneous cardiomyopathy with...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bainbridge MN, Davis EE, Choi WY, Dickson A, Martinez HR, Wang M, Dinh H, Muzny D, Pignatelli R, Katsanis N, Boerwinkle E, Gibbs R, Jefferies JL. Loss of Function Mutations in NNT Are Associated with Left Ventricular Noncompaction. Circ Cardiovasc Genet. 2015 May 29. pii: CIRCGENETICS.115.001026. [Epub ahead of print].

Id2a is required for hepatic outgrowth during liver development in zebrafish

Authors:
Khaliq M, Choi TY, So J, Shin D
Citation:
Mech Dev. 2015 May 27. pii: S0925-4773(15)00043-X. doi: 10.1016/j.mod.2015.05.001. [Epub ahead of print]
Epub:
Yes
Abstract:
During development, inhibitor of DNA binding (Id) proteins, a subclass of the helix-loop-helix family of proteins, regulate...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Khaliq M, Choi TY, So J, Shin D. Id2a is required for hepatic outgrowth during liver development in zebrafish. Mech Dev. 2015 May 27. pii: S0925-4773(15)00043-X. doi: 10.1016/j.mod.2015.05.001. [Epub ahead of print].

eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

Authors:
Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G
Citation:
Nat Comm. 2015;6:7194. doi:10.1038/ncomms8194
Epub:
Not Epub
Abstract:
MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Comm. 2015;6:7194. doi:10.1038/ncomms8194.

Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish

Authors:
Choi SY, Baek J-I, Zuo X, Kim S-H, Dunaief JL, Lipschutz JH
Citation:
IOVS. 2015;56:3361-70. doi:10.1167/iovs.14-15692
Epub:
Not Epub
Abstract:
Purpose. To characterize the function and mechanisms of cdc42 and sec10 in eye development in zebrafish. Methods. Knockdown of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Choi SY, Baek J-I, Zuo X, Kim S-H, Dunaief JL, Lipschutz JH. Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish. IOVS. 2015;56:3361-70. doi:10.1167/iovs.14-15692.

The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis

Authors:
Helker CSM, Schuermann A, Pollmann C, Chng SC, Kiefer F, Reversade B, Herzog W
Citation:
eLife 2015;10.7554/eLife.06726
Epub:
Not Epub
Abstract:
A key step in the de novo formation of the embryonic vasculature is the migration of endothelial precursors, the angioblasts,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Helker CSM, Schuermann A, Pollmann C, Chng SC, Kiefer F, Reversade B, Herzog W. The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis. eLife 2015;10.7554/eLife.06726.

Abnormal splicing switch of DMD’s penultimate exon compromises muscle fibre maintenance in myotonic dystrophy

Authors:
Rau F, Lainé J, Ramanoudjame L, Ferry A, Arandel L, Delalande O, Jollet A, Dingli F, Lee K-Y, Peccate C, Lorain S, Kabashi E, Athanasopoulos T, Koo T, Loew D, Swanson MS, Le Rumeur E, Dickson G, Allamand V, Marie J, Furling D
Citation:
Nat Comm. 2015;6:7205. doi:10.1038/ncomms8205
Epub:
Not Epub
Abstract:
Myotonic Dystrophy type 1 (DM1) is a dominant neuromuscular disease caused by nuclear-retained RNAs containing expanded CUG...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rau F, Lainé J, Ramanoudjame L, Ferry A, Arandel L, Delalande O, Jollet A, Dingli F, Lee K-Y, Peccate C, Lorain S, Kabashi E, Athanasopoulos T, Koo T, Loew D, Swanson MS, Le Rumeur E, Dickson G, Allamand V, Marie J, Furling D. Abnormal splicing switch of DMD’s penultimate exon compromises muscle fibre maintenance in myotonic dystrophy. Nat Comm. 2015;6:7205. doi:10.1038/ncomms8205.

Analysis of the nicotinamide phosphoribosyltransferase (NAMPT) family provides insight into vertebrate adaptation to different oxygen levels during the water-to-land transition

Authors:
Fang C, Guan L, Zhong Z, Gan X, He S
Citation:
FEBS J. 2015 May 25. doi: 10.1111/febs.13327. [Epub ahead of print]
Epub:
Yes
Abstract:
One of the most important events in vertebrate evolutionary history is the water-to-land transition, during which some...
Citation Extract:
Fang C, Guan L, Zhong Z, Gan X, He S. Analysis of the nicotinamide phosphoribosyltransferase (NAMPT) family provides insight into vertebrate adaptation to different oxygen levels during the water-to-land transition. FEBS J. 2015 May 25. doi: 10.1111/febs.13327. [Epub ahead of print].

Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus

Authors:
Shi J, Zhao Y, Vonderfecht T, Winey M, Klymkowsky MW
Citation:
Sci Rep. 2015;5:10283. doi:10.1038/srep10283
Epub:
Not Epub
Abstract:
Centrins (Cetns) are highly conserved, widely expressed, and multifunctional Ca2+-binding eukaryotic signature proteins best...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Shi J, Zhao Y, Vonderfecht T, Winey M, Klymkowsky MW. Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus. Sci Rep. 2015;5:10283. doi:10.1038/srep10283.

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