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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

Authors:
Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J; PROMESA investigators, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Mvp-France, Jeunemaitre X; Leducq Transatlantic MITRAL Network
Citation:
Nat Genet. 2015 Aug 24. doi: 10.1038/ng.3383. [Epub ahead of print]
Epub:
Yes
Abstract:
Nonsyndromic mitral valve prolapse (MVP) is a common degenerative cardiac valvulopathy of unknown etiology that predisposes to...
Link:
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3383.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J; PROMESA investigators, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Mvp-France, Jeunemaitre X; Leducq Transatlantic MITRAL Network. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Aug 24. doi: 10.1038/ng.3383. [Epub ahead of print].

Aquaporin 1 Is Involved in Acid Secretion by Ionocytes of Zebrafish Embryos through Facilitating CO2 Transport

Authors:
Horng JL, Chao PL, Chen PY, Shih TH, Lin LY
Citation:
PLoS One. 2015 Aug 19;10(8):e0136440. doi: 10.1371/journal.pone.0136440. eCollection 2015
Epub:
Not Epub
Abstract:
Mammalian aquaporin 1 (AQP1) is well known to function as a membrane channel for H2O and CO2 transport. Zebrafish AQP1a.1 (the...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136440
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Horng JL, Chao PL, Chen PY, Shih TH, Lin LY. Aquaporin 1 Is Involved in Acid Secretion by Ionocytes of Zebrafish Embryos through Facilitating CO2 Transport. PLoS One. 2015 Aug 19;10(8):e0136440. doi: 10.1371/journal.pone.0136440. eCollection 2015.

Singapore Grouper Iridovirus ORF75R is a Scaffold Protein Essential for Viral Assembly

Authors:
Wang F, Liu Y, Zhu Y, Ngoc Tran B, Wu J, Leong Hew C
Citation:
Sci Rep. 2015 Aug 19;5:13151. doi: 10.1038/srep13151
Epub:
Not Epub
Abstract:
Singapore Grouper Iridovirus (SGIV) is a member of nucleo cytoplasmic large DNA viruses (NCLDV). This paper reports the...
Link:
http://www.nature.com/articles/srep13151
Organism or Cell Type:
Singapore Grouper Iridovirus (SGIV)
Citation Extract:
Wang F, Liu Y, Zhu Y, Ngoc Tran B, Wu J, Leong Hew C. Singapore Grouper Iridovirus ORF75R is a Scaffold Protein Essential for Viral Assembly. Sci Rep. 2015 Aug 19;5:13151. doi: 10.1038/srep13151.

IQGAP3 Is Essential for Cell Proliferation and Motility During Zebrafish Embryonic Development

Authors:
Fang X, Zhang B, Thisse B, Bloom GS, Thisse C
Citation:
Cytoskeleton (Hoboken). 2015 Aug 19. doi: 10.1002/cm.21237. [Epub ahead of print]
Epub:
Yes
Abstract:
IQGAPs are scaffolding proteins that regulate actin assembly, exocyst function, cell motility, morphogenesis, adhesion and...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/cm.21237/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fang X, Zhang B, Thisse B, Bloom GS, Thisse C. IQGAP3 Is Essential for Cell Proliferation and Motility During Zebrafish Embryonic Development. Cytoskeleton (Hoboken). 2015 Aug 19. doi: 10.1002/cm.21237. [Epub ahead of print].

VEGF signals induce trailblazer cell identity that drives neural crest migration

Authors:
McLennan R, Schumacher LJ, Morrison JA, Teddy JM, Ridenour DA, Box AC, Semerad CL, Li H, McDowell W, Kay D, Maini PK, Baker RE, Kulesa PM
Citation:
Dev Biol. 2015 Aug 13. pii: S0012-1606(15)30124-X. doi: 10.1016/j.ydbio.2015.08.011. [Epub ahead of print]
Epub:
Yes
Abstract:
Embryonic neural crest cells travel in discrete streams to precise locations throughout the head and body. We previously showed...
Link:
http://www.sciencedirect.com/science/article/pii/S001216061530124X
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
McLennan R, Schumacher LJ, Morrison JA, Teddy JM, Ridenour DA, Box AC, Semerad CL, Li H, McDowell W, Kay D, Maini PK, Baker RE, Kulesa PM. VEGF signals induce trailblazer cell identity that drives neural crest migration. Dev Biol. 2015 Aug 13. pii: S0012-1606(15)30124-X. doi: 10.1016/j.ydbio.2015.08.011. [Epub ahead of print].

Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis

Authors:
Le Goff E, Martinand-Mari C, Martin M, Feuillard J, Boublik Y, Godefroy N, Mangeat P, Baghdiguian S, Cavalli G
Citation:
Biol Open. 2015 Aug 14. pii: bio.010835. doi: 10.1242/bio.010835. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The paradigm of developmental regulation by Polycomb group (PcG) proteins posits that they maintain silencing outside the...
Link:
http://bio.biologists.org/content/early/2015/07/28/bio.010835.long
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis
Citation Extract:
Le Goff E, Martinand-Mari C, Martin M, Feuillard J, Boublik Y, Godefroy N, Mangeat P, Baghdiguian S, Cavalli G. Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis. Biol Open. 2015 Aug 14. pii: bio.010835. doi: 10.1242/bio.010835. [Epub ahead of print].

Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum

Authors:
Garg A, Wesolowski D, Alonso D, Deitsch KW, Ben Mamoun C, Altman S
Citation:
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11935-40. doi: 10.1073/pnas.1515864112. Epub 2015 Sep 8.
Epub:
Yes
Abstract:
Identification and genetic validation of new targets from available genome sequences are critical steps toward the development...
Link:
http://www.pnas.org/content/early/2015/09/02/1515864112.abstract
Delivery Method:
Vivo-Morpholino & peptide-linked
Organism or Cell Type:
Plasmodium falciparum
Citation Extract:
Garg A, Wesolowski D, Alonso D, Deitsch KW, Ben Mamoun C, Altman S. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11935-40. doi: 10.1073/pnas.1515864112. Epub 2015 Sep 8..

Recoverin depletion accelerates cone photoresponse recovery

Authors:
Zang J, Keim J, Kastenhuber E, Gesemann M, Neuhauss SC
Citation:
Open Biol. 2015 Aug;5(8). pii: 150086. doi: 10.1098/rsob.150086
Epub:
Not Epub
Abstract:
The neuronal Ca(2+)-binding protein Recoverin has been shown to regulate phototransduction termination in mammalian rods. Here...
Link:
http://rsob.royalsocietypublishing.org/content/5/8/150086.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zang J, Keim J, Kastenhuber E, Gesemann M, Neuhauss SC. Recoverin depletion accelerates cone photoresponse recovery. Open Biol. 2015 Aug;5(8). pii: 150086. doi: 10.1098/rsob.150086.

Conserved overlapping gene arrangement, restricted expression and biochemical activities of DNA polymerase ν; (POLN)

Authors:
Takata KI, Tomida J, Reh S, Swanhart LM, Takata M, Hukriede NA, Wood RD
Citation:
J Biol Chem. 2015 Aug 12. pii: jbc.M115.677419. [Epub ahead of print]
Epub:
Yes
Abstract:
DNA polymerase ν (POLN) is one of 16 DNA polymerases encoded in vertebrate genomes. It is important to determine its gene...
Link:
http://www.jbc.org/content/early/2015/08/12/jbc.M115.677419.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Takata KI, Tomida J, Reh S, Swanhart LM, Takata M, Hukriede NA, Wood RD. Conserved overlapping gene arrangement, restricted expression and biochemical activities of DNA polymerase ν; (POLN). J Biol Chem. 2015 Aug 12. pii: jbc.M115.677419. [Epub ahead of print].

Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application

Authors:
Salewsky B, Hildebrand G, Rothe S, Parplys AC, Radszewski J, Kieslich M, Wessendorf P, Krenzlin H, Borgmann K, Nussenzweig A, Sperling K, Digweed M
Citation:
Mol Ther. 2016 Feb;24(1):117-24. doi: 10.1038/mt.2015.144. Epub 2015 Aug 12.
Epub:
Yes
Abstract:
Over 90% of patients with Nijmegen breakage syndrome (NBS), a hereditary cancer disorder, are homoallelic for a 5bp deletion in...
Link:
http://www.nature.com/mt/journal/vaop/ncurrent/full/mt2015144a.html
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Salewsky B, Hildebrand G, Rothe S, Parplys AC, Radszewski J, Kieslich M, Wessendorf P, Krenzlin H, Borgmann K, Nussenzweig A, Sperling K, Digweed M. Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application. Mol Ther. 2016 Feb;24(1):117-24. doi: 10.1038/mt.2015.144. Epub 2015 Aug 12..

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