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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders

Authors:
Li X, Kheirabadi M, Dougherty PG, Kamer KJ, Shen X, Estrella NL, Peddigari S, Pathak A, Blake SL, Sizensky E, Genio CD, Gaur AB, Dhanabal M, Girgenrath M, Sethuraman N, Qian Z
Citation:
Mol Ther Nucleic Acids. 2023 Jun 29;33:273-285. doi: 10.1016/j.omtn.2023.06.022. eCollection 2023 Sep 12
Epub:
Not Epub
Abstract:
Biological therapeutic agents are highly targeted and potent but limited in their ability to reach intracellular targets. These...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00172-5
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Li X, Kheirabadi M, Dougherty PG, Kamer KJ, Shen X, Estrella NL, Peddigari S, Pathak A, Blake SL, Sizensky E, Genio CD, Gaur AB, Dhanabal M, Girgenrath M, Sethuraman N, Qian Z. The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders. Mol Ther Nucleic Acids. 2023 Jun 29;33:273-285. doi: 10.1016/j.omtn.2023.06.022. eCollection 2023 Sep 12.

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach

Authors:
Tsurusaki T, Sato K, Imai H, Hirai K, Takahashi D, Wada T
Citation:
Sci Rep. 2023;13:12576. doi:10.1038/s41598-023-38698-2
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising type of antisense oligonucleotides, but their challenging...
Link:
https://www.nature.com/articles/s41598-023-38698-2
Citation Extract:
Tsurusaki T, Sato K, Imai H, Hirai K, Takahashi D, Wada T. Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach. Sci Rep. 2023;13:12576. doi:10.1038/s41598-023-38698-2.

Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans

Authors:
Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y, Farmer DG, Kaldas FM, Yuan X, Eltzschig HK, Kupiec-Weglinski JW
Citation:
Sci Transl Med. 2023 Aug 2;15(707):eadf2059. doi: 10.1126/scitranslmed.adf2059. Epub 2023 Aug 2. PMID: 37531413
Epub:
Not Epub
Abstract:
Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to environmental stresses, its...
Link:
https://www.science.org/doi/10.1126/scitranslmed.adf2059
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y, Farmer DG, Kaldas FM, Yuan X, Eltzschig HK, Kupiec-Weglinski JW. Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans. Sci Transl Med. 2023 Aug 2;15(707):eadf2059. doi: 10.1126/scitranslmed.adf2059. Epub 2023 Aug 2. PMID: 37531413.

Aicardi Syndrome Is a Genetically Heterogeneous Disorder

Authors:
Ha TT, Burgess R, Newman M, Moey C, Mandelstam SA, Gardner AE, Ivancevic AM, Pham D, Kumar R, Smith N, Patel C, Malone S, Ryan MM, Calvert S, van Eyk CL, Lardelli M, Berkovic SF, Leventer RJ, Richards LJ, Scheffer IE, Gecz J, Corbett MA
Citation:
Genes. 2023;14(8):1565. doi:10.3390/genes14081565
Epub:
Not Epub
Abstract:
Aicardi Syndrome (AIC) is a rare neurodevelopmental disorder recognized by the classical triad of agenesis of the corpus...
Link:
https://www.mdpi.com/2073-4425/14/8/1565
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ha TT, Burgess R, Newman M, Moey C, Mandelstam SA, Gardner AE, Ivancevic AM, Pham D, Kumar R, Smith N, Patel C, Malone S, Ryan MM, Calvert S, van Eyk CL, Lardelli M, Berkovic SF, Leventer RJ, Richards LJ, Scheffer IE, Gecz J, Corbett MA. Aicardi Syndrome Is a Genetically Heterogeneous Disorder. Genes. 2023;14(8):1565. doi:10.3390/genes14081565.

Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development

Authors:
Parast SM, Yu D, Chen C, Dickinson AJ, Chang C, Wang H
Citation:
Front Cell Dev Biol. 2023 Jul 17;11:1168643. doi: 10.3389/fcell.2023.1168643. eCollection 2023
Epub:
Not Epub
Abstract:
Polycomb group (PcG) proteins are key regulators of gene expression and developmental programs via covalent modification of...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2023.1168643/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Parast SM, Yu D, Chen C, Dickinson AJ, Chang C, Wang H. Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development. Front Cell Dev Biol. 2023 Jul 17;11:1168643. doi: 10.3389/fcell.2023.1168643. eCollection 2023.

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth

Authors:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B
Citation:
Oncogene. 2023 Jul 29. doi: 10.1038/s41388-023-02793-5. Online ahead of print
Epub:
Yes
Abstract:
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells...
Link:
https://www.nature.com/articles/s41388-023-02793-5
Citation Extract:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B. Microenvironmental Snail1-induced immunosuppression promotes melanoma growth. Oncogene. 2023 Jul 29. doi: 10.1038/s41388-023-02793-5. Online ahead of print.

mRNA location and translation rate determine protein targeting to dual destinations

Authors:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S
Citation:
Mol Cell. 2023 Jul 20:S1097-2765(23)00514-2. doi: 10.1016/j.molcel.2023.06.036. Online ahead of print
Epub:
Yes
Abstract:
Numerous proteins are targeted to two or multiple subcellular destinations where they exert distinct functional consequences....
Link:
https://www.sciencedirect.com/science/article/pii/S1097276523005142
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: MDA-MB-231
Citation Extract:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S. mRNA location and translation rate determine protein targeting to dual destinations. Mol Cell. 2023 Jul 20:S1097-2765(23)00514-2. doi: 10.1016/j.molcel.2023.06.036. Online ahead of print.

Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping

Authors:
Zhu A, Chiba S, Shimizu Y, Kunitake K, Okuno Y, Aoki Y, Yokota T
Citation:
Pharmaceutics. 2023 Jun 24;15(7):1808. doi: 10.3390/pharmaceutics15071808
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO)-mediated exon skipping has become a valuable tool for investigating gene function and...
Link:
https://www.mdpi.com/1999-4923/15/7/1808
Citation Extract:
Zhu A, Chiba S, Shimizu Y, Kunitake K, Okuno Y, Aoki Y, Yokota T. Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping. Pharmaceutics. 2023 Jun 24;15(7):1808. doi: 10.3390/pharmaceutics15071808.

BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides

Authors:
Chakravarthy M, Veedu RN
Citation:
Genes (Basel). 2019 Sep 12;10(9):705. doi: 10.3390/genes10090705
Epub:
Not Epub
Abstract:
Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site...
Link:
https://www.mdpi.com/2073-4425/10/9/705
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Chakravarthy M, Veedu RN. BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides. Genes (Basel). 2019 Sep 12;10(9):705. doi: 10.3390/genes10090705.

HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53

Authors:
Fu JL, Zheng SY, Wang Y, Hu XB, Xiao Y, Wang JM, Zhang L, Wang L, Nie Q, Hou M, Bai YY, Gan YW, Liang XM, Xie LL, Li DW
Citation:
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2221522120. doi: 10.1073/pnas.2221522120. Epub 2023 Jul 24
Epub:
Yes
Abstract:
Cataract is a leading ocular disease causing global blindness. The mechanism of cataractogenesis has not been well defined....
Link:
https://www.pnas.org/doi/10.1073/pnas.2221522120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fu JL, Zheng SY, Wang Y, Hu XB, Xiao Y, Wang JM, Zhang L, Wang L, Nie Q, Hou M, Bai YY, Gan YW, Liang XM, Xie LL, Li DW. HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2221522120. doi: 10.1073/pnas.2221522120. Epub 2023 Jul 24.

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