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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Non-canonical function of folate/folate receptor 1 during neural tube formation

Authors:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN
Citation:
bioRxiv. 2023 Jul 21:[preprint]. doi:10.1101/2023.07.19.549718
Epub:
Not Epub
Abstract:
Folate supplementation reduces the occurrence of neural tube defects, one of the most common and serious birth defects,...
Link:
https://www.biorxiv.org/content/10.1101/2023.07.19.549718v1
Delivery Method:
Vivo-Morpholino, microinjection
Organism or Cell Type:
human neural organoids from iPSCs, Xenopus laevis
Citation Extract:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN. Non-canonical function of folate/folate receptor 1 during neural tube formation. bioRxiv. 2023 Jul 21:[preprint]. doi:10.1101/2023.07.19.549718.

Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1

Authors:
Westerich KJ, Tarbashevich K, Schick J, Gupta A, Zhu M, Hull K, Romo D, Zeuschner D, Goudarzi M, Gross-Thebing T, Raz E
Citation:
Dev Cell. 2023 Jul 11:S1534-5807(23)00307-6. doi: 10.1016/j.devcel.2023.06.009. Online ahead of print
Epub:
Not Epub
Abstract:
Germ granules, condensates of phase-separated RNA and protein, are organelles that are essential for germline development in...
Link:
https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(23)00307-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Westerich KJ, Tarbashevich K, Schick J, Gupta A, Zhu M, Hull K, Romo D, Zeuschner D, Goudarzi M, Gross-Thebing T, Raz E. Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1. Dev Cell. 2023 Jul 11:S1534-5807(23)00307-6. doi: 10.1016/j.devcel.2023.06.009. Online ahead of print.

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium

Authors:
Ghersi JJ, Baldissera G, Hintzen J, Luff SA, Cheng S, Xia IF, Sturgeon CM, Nicoli S
Citation:
Nat Cell Biol. 2023 Jul 17. doi: 10.1038/s41556-023-01187-9. Online ahead of print
Epub:
Yes
Abstract:
Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are...
Link:
https://www.nature.com/articles/s41556-023-01187-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ghersi JJ, Baldissera G, Hintzen J, Luff SA, Cheng S, Xia IF, Sturgeon CM, Nicoli S. Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium. Nat Cell Biol. 2023 Jul 17. doi: 10.1038/s41556-023-01187-9. Online ahead of print.

Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection

Authors:
Choudhury NR, Urwin L, Salamaga B, Prince LR, Renshaw SA, Corrigan RM
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.07.12.548523
Epub:
Not Epub
Abstract:
Staphylococcus aureus is a bacterial pathogen that poses a major threat to human health. The ability of this bacterium to adapt...
Link:
https://www.biorxiv.org/content/10.1101/2023.07.12.548523v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Choudhury NR, Urwin L, Salamaga B, Prince LR, Renshaw SA, Corrigan RM. Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection. bioRxiv. 2023;[preprint] doi:10.1101/2023.07.12.548523 .

A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics

Authors:
Ghosh C, Popella L, Dhamodharan V, Jung J, Barquist L, Höbartner C, Vogel J
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.07.11.548539
Epub:
Not Epub
Abstract:
Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for...
Link:
https://www.biorxiv.org/content/10.1101/2023.07.11.548539v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Salmonella enterica serovar Typhimurium strain SL1344
Citation Extract:
Ghosh C, Popella L, Dhamodharan V, Jung J, Barquist L, Höbartner C, Vogel J. A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics. bioRxiv. 2023;[preprint] doi:10.1101/2023.07.11.548539.

Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo

Authors:
Cacialli P, Dogan S, Linnerz T, Pasche C, Bertrand JY
Citation:
Stem Cell Reports. 2023 Jul 11;18(7):1534-1546. doi: 10.1016/j.stemcr.2023.05.022
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs) guarantee the continuous supply of all blood lineages during life. In response to stress, HSCs...
Link:
https://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(23)00201-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cacialli P, Dogan S, Linnerz T, Pasche C, Bertrand JY. Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. Stem Cell Reports. 2023 Jul 11;18(7):1534-1546. doi: 10.1016/j.stemcr.2023.05.022.

Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer

Authors:
He S, Song W, Cui S, Li J, Jiang Y, Chen X, Peng L
Citation:
Cell Oncol (Dordr). 2023 Jul 5. doi: 10.1007/s13402-023-00839-0. Online ahead of print
Epub:
Yes
Abstract:
Purpose: MicroRNA-146b (miR-146b) alleviates experimental colitis in mice by mediating macrophage polarization and the release...
Link:
https://link.springer.com/article/10.1007/s13402-023-00839-0
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: primary bone marrow-derived macrophages (BMDMs)
Citation Extract:
He S, Song W, Cui S, Li J, Jiang Y, Chen X, Peng L. Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer. Cell Oncol (Dordr). 2023 Jul 5. doi: 10.1007/s13402-023-00839-0. Online ahead of print.

RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa

Authors:
Chessel A, De Crozé N, Molina MD, Taberner L, Dru P, Martin L, Lepage T
Citation:
Nat Commun. 2023 Jul 5;14(1):3970. doi: 10.1038/s41467-023-39606-y
Epub:
Not Epub
Abstract:
During early development of the sea urchin embryo, activation of ERK signalling in mesodermal precursors is not triggered by...
Link:
https://www.nature.com/articles/s41467-023-39606-y
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Chessel A, De Crozé N, Molina MD, Taberner L, Dru P, Martin L, Lepage T. RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa. Nat Commun. 2023 Jul 5;14(1):3970. doi: 10.1038/s41467-023-39606-y.

Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms

Authors:
Güiza J, Solís F, Valenzuela B, Arancibia D, Zamorano P, González J, Saavedra J, Neely A, Salgado M, Martínez AD, Sáez JC, Vega JL
Citation:
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2307898120. doi: 10.1073/pnas.2307898120. Epub 2023 Jul 24
Epub:
Not Epub
Abstract:
Cells of vertebrate and invertebrate organisms express proteins specialized in membrane channel-based cell-cell communication...
Link:
https://www.pnas.org/doi/10.1073/pnas.2307898120
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Güiza J, Solís F, Valenzuela B, Arancibia D, Zamorano P, González J, Saavedra J, Neely A, Salgado M, Martínez AD, Sáez JC, Vega JL. Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2307898120. doi: 10.1073/pnas.2307898120. Epub 2023 Jul 24.

Prediction of human pharmacokinetics of phosphorodiamidate morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen

Authors:
Imai S, Suda Y, Mori J, Sasaki Y, Yamada T, Kusano K
Citation:
Drug Metab Dispos. 2023 Jul 19:DMD-AR-2023-001425. doi: 10.1124/dmd.123.001425. Online ahead of print
Epub:
Yes
Abstract:
Several modified antisense oligonucleotides (ASOs) have recently been approved for clinical use. Some are phosphorodiamidate...
Link:
https://dmd.aspetjournals.org/content/early/2023/07/19/dmd.123.001425.long
Delivery Method:
intravenous (i.v.)
Organism or Cell Type:
mice, rats, cynomolgus monkeys, dogs, humans
Citation Extract:
Imai S, Suda Y, Mori J, Sasaki Y, Yamada T, Kusano K. Prediction of human pharmacokinetics of phosphorodiamidate morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen. Drug Metab Dispos. 2023 Jul 19:DMD-AR-2023-001425. doi: 10.1124/dmd.123.001425. Online ahead of print.

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