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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover

Authors:
Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C
Citation:
Dev Cell. 2017 Oct 9;43(1):71-82.e6. doi: 10.1016/j.devcel.2017.09.011
Epub:
Not Epub
Abstract:
Angiopoietin-like 4 (ANGPTL4) is a secreted signaling protein that is implicated in cardiovascular disease, metabolic disorder...
Link:
http://www.sciencedirect.com/science/article/pii/S1534580717307347
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C. Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. Dev Cell. 2017 Oct 9;43(1):71-82.e6. doi: 10.1016/j.devcel.2017.09.011.

Hey2 restricts cardiac progenitor addition to the developing heart

Authors:
Gibb N, Lazic S, Deshwar AR, Yuan X, Wilson MD, Scott IC
Citation:
bioRxiv. 2017;[preprint] doi:10.1101/199638
Epub:
Yes
Abstract:
A key event in vertebrate heart development is the timely addition of second heart field (SHF) progenitor cells to the poles of...
Link:
https://www.biorxiv.org/content/biorxiv/early/2017/10/07/199638.full.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gibb N, Lazic S, Deshwar AR, Yuan X, Wilson MD, Scott IC . Hey2 restricts cardiac progenitor addition to the developing heart. bioRxiv. 2017;[preprint] doi:10.1101/199638.

Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue

Authors:
Sanchez NE, Harty BL, O'Reilly-Pol T, Ackerman SD, Herbert AL, Holmgren M, Johnson SL, Gray RS, Monk KR
Citation:
G3 (Bethesda). 2017 Oct 5;7(10):3415-3425. doi: 10.1534/g3.117.300212
Epub:
Not Epub
Abstract:
As forward genetic screens in zebrafish become more common, the number of mutants that cannot be identified by gross morphology...
Link:
http://www.g3journal.org/content/early/2017/08/28/g3.117.300212
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez NE, Harty BL, O'Reilly-Pol T, Ackerman SD, Herbert AL, Holmgren M, Johnson SL, Gray RS, Monk KR. Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 2017 Oct 5;7(10):3415-3425. doi: 10.1534/g3.117.300212.

Zinc finger protein 365 is a new maternal LPS-binding protein that defends zebrafish embryos against gram-negative bacterial infections

Authors:
Du X, Zhou Y, Song L, Wang X, Zhang S
Citation:
FASEB J. 2017 Oct 17. pii: fj.201700694R. doi: 10.1096/fj.201700694R. [Epub ahead of print]
Epub:
Yes
Abstract:
Zinc finger protein 365 (ZNF365) is widespread in animals, but its function and mechanism remains poorly defined. Here we...
Link:
http://www.fasebj.org/doi/full/10.1096/fj.201700694R
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Du X, Zhou Y, Song L, Wang X, Zhang S. Zinc finger protein 365 is a new maternal LPS-binding protein that defends zebrafish embryos against gram-negative bacterial infections. FASEB J. 2017 Oct 17. pii: fj.201700694R. doi: 10.1096/fj.201700694R. [Epub ahead of print].

Wilms tumor protein-dependent transcription of VEGF receptor 2 and hypoxia regulate expression of the testis-promoting gene Sox9 in murine embryonic gonads

Authors:
Kirschner KM, Sciesielski LK, Krueger K, Scholz H
Citation:
J Biol Chem. 2017 Dec 8;292(49):20281-20291. doi: 10.1074/jbc.M117.816751. Epub 2017 Oct 17.
Epub:
Not Epub
Abstract:
The Wilms tumor protein 1 (WT1) has been implicated in the control of several genes in sexual development, but its function in...
Link:
http://www.jbc.org/content/early/2017/10/17/jbc.M117.816751.long
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
explant culture: murine gonads, kidneys
Citation Extract:
Kirschner KM, Sciesielski LK, Krueger K, Scholz H. Wilms tumor protein-dependent transcription of VEGF receptor 2 and hypoxia regulate expression of the testis-promoting gene Sox9 in murine embryonic gonads. J Biol Chem. 2017 Dec 8;292(49):20281-20291. doi: 10.1074/jbc.M117.816751. Epub 2017 Oct 17..

Cdc42 regulates the cellular localization of Cdc42ep1 in controlling neural crest cell migration

Authors:
Shlomi C, Kovari DT, Wei W, Keate R, Curtis JE, Nie S
Citation:
J Mol Cell Biol. 2017 Oct 6. doi: 10.1093/jmcb/mjx044. [Epub ahead of print]
Epub:
Yes
Abstract:
The member of Rho family of small GTPases Cdc42 plays important and conserved roles in cell polarity and motility. The Cdc42ep...
Link:
https://academic.oup.com/jmcb/article-abstract/doi/10.1093/jmcb/mjx044/4356862/Cdc42-regulates-the-cellular-localization-of
Citation Extract:
Shlomi C, Kovari DT, Wei W, Keate R, Curtis JE, Nie S. Cdc42 regulates the cellular localization of Cdc42ep1 in controlling neural crest cell migration. J Mol Cell Biol. 2017 Oct 6. doi: 10.1093/jmcb/mjx044. [Epub ahead of print].

Guidelines for morpholino use in zebrafish

Authors:
Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB
Citation:
PLoS Genet. 2017 Oct 19;13(10):e1007000. doi: 10.1371/journal.pgen.1007000. eCollection 2017 Oct
Epub:
Not Epub
Abstract:
No abstract available.
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007000
Organism or Cell Type:
zebrafish
Citation Extract:
Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB. Guidelines for morpholino use in zebrafish. PLoS Genet. 2017 Oct 19;13(10):e1007000. doi: 10.1371/journal.pgen.1007000. eCollection 2017 Oct.

Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8

Authors:
Kim HT, Lee MS, Jeong YM, Ro H, Kim DI, Shin YH, Kim JE, Hwang KS, Choi JH, Bahn M, Lee JJ, Lee SH, Bae YK, Lee JS, Choi JK, Kim NS, Yeo CY, Kim CH
Citation:
Sci Rep. 2017 Oct 16;7(1):13278. doi: 10.1038/s41598-017-13429-6
Epub:
Not Epub
Abstract:
Wnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of...
Link:
https://www.nature.com/articles/s41598-017-13429-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim HT, Lee MS, Jeong YM, Ro H, Kim DI, Shin YH, Kim JE, Hwang KS, Choi JH, Bahn M, Lee JJ, Lee SH, Bae YK, Lee JS, Choi JK, Kim NS, Yeo CY, Kim CH. Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep. 2017 Oct 16;7(1):13278. doi: 10.1038/s41598-017-13429-6.

Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle

Authors:
Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA
Citation:
Nat Commun. 2017 Oct 16;8(1):941. doi: 10.1038/s41467-017-00924-7
Epub:
Not Epub
Abstract:
Exon skipping is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), employing morpholino antisense...
Link:
https://www.nature.com/articles/s41467-017-00924-7
Delivery Method:
injection, retro-orbital
Organism or Cell Type:
Mice, C57Bl/10ScSn-mdx/J or C57Bl/10ScSnJ (Bl10 or wild-type)
Citation Extract:
Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA. Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle. Nat Commun. 2017 Oct 16;8(1):941. doi: 10.1038/s41467-017-00924-7.

Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration

Authors:
Baek KI, Packard RR, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK
Citation:
Antioxid Redox Signal. 2017 Oct 17. doi: 10.1089/ars.2017.7166. [Epub ahead of print]
Epub:
Yes
Abstract:
AIMS: Redox active ultrafine particles (UFP, d < 0.2 µm) promote vascular oxidative stress and atherosclerosis. Notch...
Link:
http://online.liebertpub.com/doi/abs/10.1089/ars.2017.7166
Organism or Cell Type:
zebrafish
Citation Extract:
Baek KI, Packard RR, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxid Redox Signal. 2017 Oct 17. doi: 10.1089/ars.2017.7166. [Epub ahead of print].

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