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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals

Authors:
Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA
Citation:
Development. 2015 Apr 1;142(7):1254-66. doi: 10.1242/dev.119735
Epub:
Not Epub
Abstract:
Development of the metanephric kidney depends on tightly regulated interplay between self-renewal and differentiation of a...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
organ culture: mouse kidney culture
Citation Extract:
Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015 Apr 1;142(7):1254-66. doi: 10.1242/dev.119735.

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled

Authors:
Miyatake K, Kusakabe M, Takahashi C, Nishida E
Citation:
Nat Commun. 2015 Mar 31;6:6666. doi: 10.1038/ncomms7666
Epub:
Not Epub
Abstract:
Cilia are essential for embryogenesis and maintenance of homeostasis, but little is known about the signalling pathways that...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Miyatake K, Kusakabe M, Takahashi C, Nishida E. ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. Nat Commun. 2015 Mar 31;6:6666. doi: 10.1038/ncomms7666.

HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology

Authors:
Sepulveda-Diaz JE, Naini SMA, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D
Citation:
Brain. 2015;[Epub ahead of print] doi:10.1093/brain/awv056
Epub:
Yes
Abstract:
Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sepulveda-Diaz JE, Naini SMA, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology. Brain. 2015;[Epub ahead of print] doi:10.1093/brain/awv056.

Functional Loss of Semaphorin 3C and/or Semaphorin 3D and Their Epistatic Interaction with Ret Are Critical to Hirschsprung Disease Liability

Authors:
Jiang Q, Arnold S, Heanue T, Kilambi KP, Doan B, Kapoor A, Ling AY, Sosa MX, Guy M, Jiang Q, Burzynski G, West K, Bessling S, Griseri P, Amiel J, Fernandez RM, Verheij JBGM, Hofstra RMW, Borrego S, Lyonnet S, Ceccherini I, Gray JJ, Pachnis V, McCallion AS, Chakravarti A
Citation:
Am J Hum Genet. 2015;96(4):581-96. doi: 10.1016/j.ajhg.2015.02.014
Epub:
Not Epub
Abstract:
Innervation of the gut is segmentally lost in Hirschsprung disease (HSCR), a consequence of cell-autonomous and non-autonomous...
Organism or Cell Type:
zebrafish
Citation Extract:
Jiang Q, Arnold S, Heanue T, Kilambi KP, Doan B, Kapoor A, Ling AY, Sosa MX, Guy M, Jiang Q, Burzynski G, West K, Bessling S, Griseri P, Amiel J, Fernandez RM, Verheij JBGM, Hofstra RMW, Borrego S, Lyonnet S, Ceccherini I, Gray JJ, Pachnis V, McCallion AS, Chakravarti A. Functional Loss of Semaphorin 3C and/or Semaphorin 3D and Their Epistatic Interaction with Ret Are Critical to Hirschsprung Disease Liability. Am J Hum Genet. 2015;96(4):581-96. doi: 10.1016/j.ajhg.2015.02.014.

Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells

Authors:
Tarbashevich K, Reichman-Fried M, Grimaldi C, Raz E
Citation:
Curr Biol. 2015;[Epub ahead of print] doi:10.1016/j.cub.2015.02.071
Epub:
Yes
Abstract:
Directional cell migration requires cell polarization with respect to the distribution of the guidance cue. Cell polarization...
Organism or Cell Type:
zebrafish
Citation Extract:
Tarbashevich K, Reichman-Fried M, Grimaldi C, Raz E. Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Curr Biol. 2015;[Epub ahead of print] doi:10.1016/j.cub.2015.02.071.

CHD2 variants are a risk factor for photosensitivity in epilepsy

Authors:
Galizia EC, Myers CT, Leu C, de Kovel CG, Afrikanova T, Cordero-Maldonado ML, Martins TG, Jacmin M, Drury S, Krishna Chinthapalli V, Muhle H, Pendziwiat M, Sander T, Ruppert AK, Møller RS, Thiele H, Krause R, Schubert J, Lehesjoki AE, Nürnberg P, Lerche H; EuroEPINOMICS CoGIE Consortium, Palotie A, Coppola A, Striano S, Gaudio LD, Boustred C, Schneider AL, Lench N, Jocic-Jakubi B, Covanis A, Capovilla G, Veggotti P, Piccioli M, Parisi P, Cantonetti L, Sadleir LG, Mullen SA, Berkovic SF, Stephani U, Helbig I, Crawford AD, Esguerra CV, Kasteleijn-Nolst Trenité DG, Koeleman BP, Mefford HC, Scheffer IE, Sisodiya SM
Citation:
Brain. 2015 Mar 17. pii: awv052. [Epub ahead of print]
Epub:
Yes
Abstract:
Photosensitivity is a heritable abnormal cortical response to flickering light, manifesting as particular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Galizia EC, Myers CT, Leu C, de Kovel CG, Afrikanova T, Cordero-Maldonado ML, Martins TG, Jacmin M, Drury S, Krishna Chinthapalli V, Muhle H, Pendziwiat M, Sander T, Ruppert AK, Møller RS, Thiele H, Krause R, Schubert J, Lehesjoki AE, Nürnberg P, Lerche H; EuroEPINOMICS CoGIE Consortium, Palotie A, Coppola A, Striano S, Gaudio LD, Boustred C, Schneider AL, Lench N, Jocic-Jakubi B, Covanis A, Capovilla G, Veggotti P, Piccioli M, Parisi P, Cantonetti L, Sadleir LG, Mullen SA, Berkovic SF, Stephani U, Helbig I, Crawford AD, Esguerra CV, Kasteleijn-Nolst Trenité DG, Koeleman BP, Mefford HC, Scheffer IE, Sisodiya SM. CHD2 variants are a risk factor for photosensitivity in epilepsy. Brain. 2015 Mar 17. pii: awv052. [Epub ahead of print].

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood

Authors:
Nasif S, de Souza FSJ, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M
Citation:
PNAS. 2015;[Epub ahead of print] doi:10.1073/pnas.1500672112
Epub:
Yes
Abstract:
Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nasif S, de Souza FSJ, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M. Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. PNAS. 2015;[Epub ahead of print] doi:10.1073/pnas.1500672112.

An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system

Authors:
Bestman JE, Huang LC, Lee-Osbourne J, Cheung P, Cline HT
Citation:
Dev Biol. 2015 Dec 15;408(2):269-91. doi: 10.1016/j.ydbio.2015.03.010. Epub 2015 Mar 27.
Epub:
Not Epub
Abstract:
Neurogenesis in the brain of Xenopus laevis continues throughout larval stages of development. We developed a 2-tier screen to...
Delivery Method:
electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bestman JE, Huang LC, Lee-Osbourne J, Cheung P, Cline HT. An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system. Dev Biol. 2015 Dec 15;408(2):269-91. doi: 10.1016/j.ydbio.2015.03.010. Epub 2015 Mar 27..

Mutations in TUBGCP4 Alter Microtubule Organization via the γ-Tubulin Ring Complex in Autosomal-Recessive Microcephaly with Chorioretinopathy

Authors:
Scheidecker S, Etard C, Haren L, Stoetzel C, Hull S, Arno G, Plagnol V, Drunat S, Passemard S, Toutain A, Obringer C, Koob M, Geoffroy V, Marion V, Strähle U, Ostergaard P, Verloes A, Merdes A, Moore AT, Dollfus H
Citation:
Am J Hum Genet. 2015 Mar 25. pii: S0002-9297(15)00064-6. doi: 10.1016/j.ajhg.2015.02.011. [Epub ahead of print]
Epub:
Yes
Abstract:
We have identified TUBGCP4 variants in individuals with autosomal-recessive microcephaly and chorioretinopathy. Whole-exome...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Scheidecker S, Etard C, Haren L, Stoetzel C, Hull S, Arno G, Plagnol V, Drunat S, Passemard S, Toutain A, Obringer C, Koob M, Geoffroy V, Marion V, Strähle U, Ostergaard P, Verloes A, Merdes A, Moore AT, Dollfus H. Mutations in TUBGCP4 Alter Microtubule Organization via the γ-Tubulin Ring Complex in Autosomal-Recessive Microcephaly with Chorioretinopathy. Am J Hum Genet. 2015 Mar 25. pii: S0002-9297(15)00064-6. doi: 10.1016/j.ajhg.2015.02.011. [Epub ahead of print].

In silico screening based on predictive algorithms as a design tool for exon skipping oligonucleotides in duchenne muscular dystrophy

Authors:
Echigoya Y, Mouly V, Garcia L, Yokota T, Duddy W
Citation:
PLoS One. 2015 Mar 27;10(3):e0120058. doi: 10.1371/journal.pone.0120058. eCollection 2015
Epub:
Not Epub
Abstract:
The use of antisense 'splice-switching' oligonucleotides to induce exon skipping represents a potential therapeutic...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human myotubes
Citation Extract:
Echigoya Y, Mouly V, Garcia L, Yokota T, Duddy W. In silico screening based on predictive algorithms as a design tool for exon skipping oligonucleotides in duchenne muscular dystrophy. PLoS One. 2015 Mar 27;10(3):e0120058. doi: 10.1371/journal.pone.0120058. eCollection 2015.

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