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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Diel rhythm of the inflammatory cytokine il1b in the Japanese medaka (Oryzias latipes) regulated by core components of the circadian clock

Authors:
Takeuchi T, Hata T, Miyanishi H, Yuasa T, Setoguchi S, Takeda A, Morimoto N, Hikima JI, Sakai M, Kono T
Citation:
Fish Shellfish Immunol. 2022 Jun 17:S1050-4648(22)00338-2. doi: 10.1016/j.fsi.2022.06.020. Online ahead of print
Epub:
Yes
Abstract:
In recent years, studies on circadian control in immunity have been actively conducted in mammals, but little is known about...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1050464822003382
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Takeuchi T, Hata T, Miyanishi H, Yuasa T, Setoguchi S, Takeda A, Morimoto N, Hikima JI, Sakai M, Kono T. Diel rhythm of the inflammatory cytokine il1b in the Japanese medaka (Oryzias latipes) regulated by core components of the circadian clock. Fish Shellfish Immunol. 2022 Jun 17:S1050-4648(22)00338-2. doi: 10.1016/j.fsi.2022.06.020. Online ahead of print.

Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos

Authors:
Kupai A, Nakahara H, Voss KM, Hirano MS, Rodriguez A, Lackey DL, Murayama JF, Mathieson CJ, Shan B, Horton EC, Curtis GH, Huang J, Hille MB
Citation:
Dev Dyn. 2022 Jun 15. doi:10.1002/dvdy.508. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Cadherin-associated protein p120 catenin regulates cell adhesion and migration in cell cultures and is required for...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.508
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kupai A, Nakahara H, Voss KM, Hirano MS, Rodriguez A, Lackey DL, Murayama JF, Mathieson CJ, Shan B, Horton EC, Curtis GH, Huang J, Hille MB. Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos. Dev Dyn. 2022 Jun 15. doi:10.1002/dvdy.508. Online ahead of print.

Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613

Authors:
Guardado Rivas MO, Stuart SD, Thach D, Dahan M, Shorr R, Zachar Z, Bingham PM
Citation:
PLoS ONE. 2022;17(6):e0269620. doi:10.1371/journal.pone.0269620
Epub:
Not Epub
Abstract:
Clinical targeting of the altered metabolism of tumor cells has long been considered an attractive hypothetical approach....
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269620
Delivery Method:
cell bathing, Vivo-Morpholino
Organism or Cell Type:
cell culture: AsPC-1
Citation Extract:
Guardado Rivas MO, Stuart SD, Thach D, Dahan M, Shorr R, Zachar Z, Bingham PM. Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613. PLoS ONE. 2022;17(6):e0269620. doi:10.1371/journal.pone.0269620.

Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy

Authors:
De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Robert Liu W, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Martijn Bos J, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA
Citation:
Circ Genom Precis Med. 2022 Jun 7:101161CIRCGEN121003563. doi:10.1161/CIRCGEN.121.003563
Epub:
Yes
Abstract:
BACKGROUND: The study of hypertrophic cardiomyopathy (HCM) - a severe Mendelian disease - can yield insight into the mechanisms...
Link:
https://www.ahajournals.org/doi/10.1161/CIRCGEN.121.003563
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Robert Liu W, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Martijn Bos J, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA. Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy. Circ Genom Precis Med. 2022 Jun 7:101161CIRCGEN121003563. doi:10.1161/CIRCGEN.121.003563.

Anti-cancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer

Authors:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
Citation:
Research Square 2022:[preprint] doi:10.21203/rs.3.rs-1704679/v1
Epub:
Not Epub
Abstract:
Background: Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Colorectal cancer (CRC...
Link:
https://www.researchsquare.com/article/rs-1704679/v1
Delivery Method:
peptide-linked exosomal
Organism or Cell Type:
cell culture: CRC
Citation Extract:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X. Anti-cancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Research Square 2022:[preprint] doi:10.21203/rs.3.rs-1704679/v1.

Cyclin B3 implements timely vertebrate oocyte arrest for fertilization

Authors:
Bouftas N, Schneider L, Halder M, Demmig R, Baack M, Cladière D, Walter M, Al Abdallah H, Kleinhempel C, Müller J, Passarelli F, Wehrle P, Heim A, Wassmann K, Mayer TU
Citation:
bioRxiv. 2022;[preprint] doi: doi:10.1101/2022.06.04.494806
Epub:
Not Epub
Abstract:
To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.04.494806v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Bouftas N, Schneider L, Halder M, Demmig R, Baack M, Cladière D, Walter M, Al Abdallah H, Kleinhempel C, Müller J, Passarelli F, Wehrle P, Heim A, Wassmann K, Mayer TU. Cyclin B3 implements timely vertebrate oocyte arrest for fertilization. bioRxiv. 2022;[preprint] doi: doi:10.1101/2022.06.04.494806.

Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure

Authors:
Christodoulou N, Skourides PA
Citation:
Development. 2022;[Epub] doi:10.1242/dev.200358
Epub:
Yes
Abstract:
Neural tube closure (NTC) is a fundamental process during vertebrate development and is indispensable for the formation of the...
Link:
https://journals.biologists.com/dev/article-abstract/doi/10.1242/dev.200358/275604/Distinct-spatiotemporal-contribution-of
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Christodoulou N, Skourides PA. Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure. Development. 2022;[Epub] doi:10.1242/dev.200358.

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

Authors:
Doccini S, Marchese M, Morani F, Gammaldi N, Mero S, Pezzini F, Soliymani R, Santi M, Signore G, Ogi A, Rocchiccioli S, Kanninen KM, Simonati A, Lalowski MM, Santorelli FM
Citation:
Cells. 2022;11:1840. doi:10.3390/cells11111840
Epub:
Not Epub
Abstract:
CLN5 disease (MIM: 256731) represents a rare late-infantile form of neuronal ceroid lipofuscinosis (NCL), caused by mutations...
Link:
https://www.mdpi.com/2073-4409/11/11/1840
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Doccini S, Marchese M, Morani F, Gammaldi N, Mero S, Pezzini F, Soliymani R, Santi M, Signore G, Ogi A, Rocchiccioli S, Kanninen KM, Simonati A, Lalowski MM, Santorelli FM. Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease. Cells. 2022;11:1840. doi:10.3390/cells11111840.

U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma

Authors:
Vorlova S, Blahetek G, Barbieri R, Kerstan Y, Rosa A, Bundalo M, Egg M, Butt E, Henke E, Dölken L, Houben R, Schilling B, Fischer U, Erhard F, Zernecke A
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.01.479622
Epub:
Not Epub
Abstract:
Activation of intronic polyadenylation signals results in premature cleavage and polyadenylation (PCPA). The majority of...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.01.479622v1
Delivery Method:
Vivo-Morpholino Endo-Porter
Organism or Cell Type:
cell culture: UACC-257, HeLe
Citation Extract:
Vorlova S, Blahetek G, Barbieri R, Kerstan Y, Rosa A, Bundalo M, Egg M, Butt E, Henke E, Dölken L, Houben R, Schilling B, Fischer U, Erhard F, Zernecke A. U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.01.479622.

Ultrasensitive Detection of Exosomal miRNA with PMO- Graphene Quantum Dots Functionalized Field Effect Transistor Biosensor

Authors:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao M-M, Zhang Z-Y, Zhang G-J
Citation:
iScience. 2022;[Epub] doi:10.1016/j.isci.2022.104522
Epub:
Not Epub
Abstract:
Compared to the conventional DNA probe immobilization on the planar surface, nanoparticles-based DNA probes enable more RNA...
Link:
https://www.cell.com/iscience/pdf/S2589-0042(22)00793-3.pdf
Citation Extract:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao M-M, Zhang Z-Y, Zhang G-J. Ultrasensitive Detection of Exosomal miRNA with PMO- Graphene Quantum Dots Functionalized Field Effect Transistor Biosensor. iScience. 2022;[Epub] doi:10.1016/j.isci.2022.104522.

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