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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Authors:
Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, Haward F, Adams IR, Caceres JF, Preyzner P, von Kriegsheim A, Dunlop MG, Din FV, Myant KB
Citation:
Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z
Epub:
Not Epub
Abstract:
Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are...
Link:
https://www.nature.com/articles/s41467-022-30489-z
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse intestine cells
Citation Extract:
Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, Haward F, Adams IR, Caceres JF, Preyzner P, von Kriegsheim A, Dunlop MG, Din FV, Myant KB. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z.

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

Authors:
Powell GT, Zhao Y, Faro A, Stickney H, Novellasdemunt L, Henriques P, Gestri G, White ER, Ren J, Lu W, Young RM, Hawkins TA, Cavodeassi F, Schwarz Q, Dreosti E, Raible DW, Li VSW, Wright GJ, Jones EY, Wilson SW
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492129
Epub:
Not Epub
Abstract:
Neurons on left and right sides of the nervous system frequently show asymmetric properties but how these differences arise is...
Link:
https://www.biorxiv.org/content/10.1101/2022.05.16.492129v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Powell GT, Zhao Y, Faro A, Stickney H, Novellasdemunt L, Henriques P, Gestri G, White ER, Ren J, Lu W, Young RM, Hawkins TA, Cavodeassi F, Schwarz Q, Dreosti E, Raible DW, Li VSW, Wright GJ, Jones EY, Wilson SW. Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492129 .

Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion

Authors:
Kwon V, Cai P, Dixon CT, Hamlin V, Spencer CG, Rojas AM, Hamilton M, Shiau CE
Citation:
Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z
Epub:
Not Epub
Abstract:
Inflammation is known to disrupt normal behavior, yet the underlying neuroimmune interactions remain elusive. Here, we...
Link:
https://www.nature.com/articles/s42003-022-03410-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kwon V, Cai P, Dixon CT, Hamlin V, Spencer CG, Rojas AM, Hamilton M, Shiau CE. Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion. Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z.

The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor

Authors:
Parshina EA, Orlov EE, Zaraisky AG, Martynova NY
Citation:
Inter J Mol Sci. 2022;23(10):5627. doi:10.3390/ijms23105627
Epub:
Not Epub
Abstract:
Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a...
Link:
https://www.mdpi.com/1422-0067/23/10/5627/htm
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Parshina EA, Orlov EE, Zaraisky AG, Martynova NY. The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor. Inter J Mol Sci. 2022;23(10):5627. doi:10.3390/ijms23105627.

BDNF signaling in Hebbian and Stentian structural plasticity in the developing visual system

Authors:
Kutsarova E, Schohl A, Munz M, Wang A, Zhang YY, Bilash OM, Ruthazer ES
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463583
Epub:
Not Epub
Abstract:
During development, patterned neural activity instructs topographic map refinement. Axons with similar patterns of neural...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.07.463583v3
Delivery Method:
ocular injection then electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kutsarova E, Schohl A, Munz M, Wang A, Zhang YY, Bilash OM, Ruthazer ES. BDNF signaling in Hebbian and Stentian structural plasticity in the developing visual system. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463583 .

Transmembrane Protein 184A and Syndecan-4 function in the same pathway to promote angiogenesis

Authors:
Altenburg LM, O'Toole RA, Ciabattoni GO, Papov IV, Pasch LM, Maslonka BE, Lowe-Krentz LJ
Citation:
FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.L8077
Epub:
Not Epub
Abstract:
Morpholino (MO) knockdown (KD) of the novel vascular heparin receptor, Transmembrane protein 184A (TMEM184A), increases...
Link:
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2022.36.S1.L8077
Delivery Method:
injection
Organism or Cell Type:
zebrafish
Citation Extract:
Altenburg LM, O'Toole RA, Ciabattoni GO, Papov IV, Pasch LM, Maslonka BE, Lowe-Krentz LJ. Transmembrane Protein 184A and Syndecan-4 function in the same pathway to promote angiogenesis. FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.L8077.

microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury

Authors:
Slevin E, Wan Y, Harrison K, Zhang Y, Li X, Li T, Lorenzo SR, Xu W, Klaunig JE, Shetty AK, Meng F
Citation:
FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231
Epub:
Not Epub
Abstract:
Background: Reversion of activated hepatic stellate cells (HSCs) to quiescence is likely to be a promising pathway in liver...
Link:
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2022.36.S1.R4231
Organism or Cell Type:
mice
Citation Extract:
Slevin E, Wan Y, Harrison K, Zhang Y, Li X, Li T, Lorenzo SR, Xu W, Klaunig JE, Shetty AK, Meng F. microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury. FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231.

Casimersen for the treatment of Duchenne muscular dystrophy

Authors:
Zakeri SE, Pradeep SP, Kasina V, Laddha AP, Manautou JE, Bahal R
Citation:
Trends Pharmacol Sci. 2022 May 14:S0165-6147(22)00089-X. doi: 10.1016/j.tips.2022.04.009. Online ahead of print
Epub:
Not Epub
Abstract:
Casimersen is a single-stranded, antisense phosphorodiamidate morpholino oligonucleotide where six-membered morpholino rings...
Link:
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(22)00089-X
Citation Extract:
Zakeri SE, Pradeep SP, Kasina V, Laddha AP, Manautou JE, Bahal R. Casimersen for the treatment of Duchenne muscular dystrophy. Trends Pharmacol Sci. 2022 May 14:S0165-6147(22)00089-X. doi: 10.1016/j.tips.2022.04.009. Online ahead of print.

SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine

Authors:
Wang ZW, Pan JJ, Hu JF, Zhang JQ, Huang L, Huang Y, Liao CY, Yang C, Chen ZW, Wang YD, Shen BY, Tian YF, Chen S
Citation:
Cell Rep. 2022 May 10;39(6):110813. doi: 10.1016/j.celrep.2022.110813
Epub:
Not Epub
Abstract:
Serine/arginine-rich splicing factor 3 (SRSF3) regulates mRNA alternative splicing of more than 90% of protein-coding genes,...
Link:
https://www.cell.com/cell-reports/pdfExtended/S2211-1247(22)00584-8
Organism or Cell Type:
cell culture: human pancreatic cancer Panc1 and BXPC3
Citation Extract:
Wang ZW, Pan JJ, Hu JF, Zhang JQ, Huang L, Huang Y, Liao CY, Yang C, Chen ZW, Wang YD, Shen BY, Tian YF, Chen S. SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine. Cell Rep. 2022 May 10;39(6):110813. doi: 10.1016/j.celrep.2022.110813.

Single cell transcriptomics identifies conserved regulators of neurosecretory lineages

Authors:
Steger J, Cole AG, Denner A, Lebedeva T, Genikhovich G, Ries A, Reischl R, Taudes E, Lassnig M, Technau U
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.11.491463
Epub:
Not Epub
Abstract:
Communication in bilaterian nervous systems is mediated by electrical and secreted signals, however, the evolutionary origin...
Link:
https://www.biorxiv.org/content/10.1101/2022.05.11.491463v1
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Steger J, Cole AG, Denner A, Lebedeva T, Genikhovich G, Ries A, Reischl R, Taudes E, Lassnig M, Technau U. Single cell transcriptomics identifies conserved regulators of neurosecretory lineages. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.11.491463.

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