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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12321 scientific papers returned from the database with the search filters currently being used below.

AMPK complex activation promotes sarcolemmal repair in dysferlinopathy

Authors:
Ono H, Suzuki N, Shin-Kanno S-i, Kawahara G, Izumi R, Takahashi T, Kitajima Y, Osana S, Nakamura N, Akiyama T, Ikeda K, Shijo T, Mitsuzawa S, Nagatomi R, Araki N, Yasui A, Warita H, Hayashi YK, Miyake K,i Aoki M
Citation:
Molec Ther. 2020;[Epub ahead of print] doi:10.1016/j.ymthe.2020.02.006
Epub:
Yes
Abstract:
Mutations in dysferlin are responsible for a group of progressive, recessively inherited muscular dystrophies known as...
Link:
https://www.sciencedirect.com/science/article/pii/S1525001620300927
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ono H, Suzuki N, Shin-Kanno S-i, Kawahara G, Izumi R, Takahashi T, Kitajima Y, Osana S, Nakamura N, Akiyama T, Ikeda K, Shijo T, Mitsuzawa S, Nagatomi R, Araki N, Yasui A, Warita H, Hayashi YK, Miyake K,i Aoki M. AMPK complex activation promotes sarcolemmal repair in dysferlinopathy. Molec Ther. 2020;[Epub ahead of print] doi:10.1016/j.ymthe.2020.02.006.

Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis

Authors:
Dobrzycki T, Mahony CB, Krecsmarik M, Koyunlar C, Rispoli R, Peulen-Zink J, Gussinklo K, Fedlaoui B, de Pater E, Patient R, Monteiro R
Citation:
Comm Biol. 2020;3(1):71 doi:10.1038/s42003-020-0798-3
Epub:
Not Epub
Abstract:
Gata2 is a key transcription factor required to generate Haematopoietic Stem and Progenitor Cells (HSPCs) from haemogenic...
Link:
https://www.nature.com/articles/s42003-020-0798-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dobrzycki T, Mahony CB, Krecsmarik M, Koyunlar C, Rispoli R, Peulen-Zink J, Gussinklo K, Fedlaoui B, de Pater E, Patient R, Monteiro R. Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Comm Biol. 2020;3(1):71 doi:10.1038/s42003-020-0798-3.

Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human

Authors:
Qiu Y, Sun S, Yua X, Zhou J, Cai W, Qian L
Citation:
Biochim Biophys Acta: Molec Cell Bio Lipid. 2020;[Epub ahead of print] doi:10.1016/j.bbalip.2020.158663
Epub:
Yes
Abstract:
Carboxyl ester lipase (Cel), is a lipolytic enzyme secreted by the pancreas, which hydrolyzes various species of lipids in the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S138819812030055X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Qiu Y, Sun S, Yua X, Zhou J, Cai W, Qian L. Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human. Biochim Biophys Acta: Molec Cell Bio Lipid. 2020;[Epub ahead of print] doi:10.1016/j.bbalip.2020.158663.

Observation of Water Permeability in Xenopus Oocytes Expressing Gap Junction Proteins

Authors:
Hamdan J, DePriest A, Skerrett IM
Citation:
Biophys J. 2020;118(3)supp1:274A. doi:10.1016/j.bpj.2019.11.1574
Epub:
Not Epub
Abstract:
Gap junctions induce electrical and biochemical coupling of animal cells and play crucial roles in cell communication,...
Link:
https://www.cell.com/biophysj/pdf/S0006-3495(19)32507-X.pdf
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Hamdan J, DePriest A, Skerrett IM. Observation of Water Permeability in Xenopus Oocytes Expressing Gap Junction Proteins. Biophys J. 2020;118(3)supp1:274A. doi:10.1016/j.bpj.2019.11.1574.

Functional architecture of deleterious genetic variants in the genome of a Wrangel Island mammoth

Authors:
Fry E, Kim SK, Chigurapti S, Mika KM, Ratan A, Dammermann A, Mitchell BJ, Miller W, Lynch VJ
Citation:
Genome Bio Evol. 2020;evz279 [Epub] doi:10.1093/gbe/evz279
Epub:
Not Epub
Abstract:
Woolly mammoths were among the most abundant cold adapted species during the Pleistocene. Their once large populations went...
Link:
https://academic.oup.com/gbe/advance-article/doi/10.1093/gbe/evz279/5727767
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Fry E, Kim SK, Chigurapti S, Mika KM, Ratan A, Dammermann A, Mitchell BJ, Miller W, Lynch VJ. Functional architecture of deleterious genetic variants in the genome of a Wrangel Island mammoth. Genome Bio Evol. 2020;evz279 [Epub] doi:10.1093/gbe/evz279.

miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations

Authors:
Hoelscher CS, Stich T, Diehm A, Lahm H, Dreßen M, Zhang Z, Neb I, Aherrahrou Z, Erdmann J, Schunkert H, Santamaria G, Cuda G, Gilsbach R, Hein L, Lange R, Hassel D, Krane M, Doppler AS
Citation:
Int J Molec Sci. 2020;21(3);1158. doi:10.3390/ijms21031158
Epub:
Not Epub
Abstract:
MicroRNAs (miRs) appear to be major, yet poorly understood players in regulatory networks guiding cardiogenesis. We sought to...
Link:
https://www.mdpi.com/1422-0067/21/3/1158
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hoelscher CS, Stich T, Diehm A, Lahm H, Dreßen M, Zhang Z, Neb I, Aherrahrou Z, Erdmann J, Schunkert H, Santamaria G, Cuda G, Gilsbach R, Hein L, Lange R, Hassel D, Krane M, Doppler AS. miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations. Int J Molec Sci. 2020;21(3);1158. doi:10.3390/ijms21031158.

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow

Authors:
Lundin V, Sugden WW, Theodore LN, Sousa PM, Han A, Chou S, Wrighton PJ, Cox AG, Ingber DE, Goessling W, Daley GQ, North TE
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.006
Epub:
Yes
Abstract:
Hematopoietic stem and progenitor cells (HSPCs), first specified from hemogenic endothelium (HE) in the ventral dorsal aorta (...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30007-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lundin V, Sugden WW, Theodore LN, Sousa PM, Han A, Chou S, Wrighton PJ, Cox AG, Ingber DE, Goessling W, Daley GQ, North TE. YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.006.

Mechanism for neurotransmitter-receptor matching

Authors:
Hammond-Weinberger DR, Wang Y, Glavis-Bloom A, Spitzer NC
Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1916600117
Epub:
Yes
Abstract:
Synaptic communication requires the expression of functional postsynaptic receptors that match the presynaptically released...
Link:
https://www.pnas.org/content/early/2020/02/07/1916600117
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture, Xenopus
Citation Extract:
Hammond-Weinberger DR, Wang Y, Glavis-Bloom A, Spitzer NC. Mechanism for neurotransmitter-receptor matching. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1916600117.

Cryptic exon activation causes dystrophinopathy in two Chinese families

Authors:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q
Citation:
Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z
Epub:
Yes
Abstract:
The X-linked recessive degenerative disease dystrophinopathy results from variants in the DMD gene. Given the large size and...
Link:
https://www.nature.com/articles/s41431-020-0578-z
Citation Extract:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q. Cryptic exon activation causes dystrophinopathy in two Chinese families. Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z.

Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy

Authors:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F
Citation:
J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):768-782. doi: 10.1002/jcsm.12542. Epub 2020 Feb 7. PMID: 32031328; PMCID: PMC7296258
Epub:
Yes
Abstract:
BACKGROUND: Spinal muscular atrophy (SMA) is caused by genetic defects in the survival motor neuron 1 (SMN1) gene that lead to...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7296258/
Delivery Method:
s.c. injection
Organism or Cell Type:
mice
Citation Extract:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F. Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy. J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):768-782. doi: 10.1002/jcsm.12542. Epub 2020 Feb 7. PMID: 32031328; PMCID: PMC7296258.

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